Navigation Links
Research shows that a prolonged fertility window can cause recurrent miscarriage
Date:1/4/2013

Researchers at Warwick Medical School have discovered that recurrent pregnancy loss can be due to a dysfunctional monthly fertility window. The study, led by Professor Jan Brosens and Professor Siobhan Quenby of the Division of Reproductive Health, sheds new light on the mechanisms that determine the timing and duration of the fertility window and how that may increase the chances of miscarriage.

The release of the cytokine IL-33 and the activation of its receptor (ST2) in cells in the uterus induces an inflammatory response that controls the stage that we are familiar with as the two to three days of peak fertility.

Work at the Clinical Sciences Research Laboratories at University Hospital, Coventry, showed clearly that in patients with a record of recurrent pregnancy loss, this inflammatory response was prolonged. When the fertility window remains open too long, embryos implant out-of-phase into an environment that cannot support the pregnancy, which leads to miscarriage.

Professor Quenby explained what this discovery means for those who suffer from persistent pregnancy loss, "The study fundamentally changes our understanding of the issue with far reaching clinical implications. The IL-33/ST2 pathway is already considered to be a major target for therapeutic interventions across Alzheimer's, cardiovascular disease, obesity, asthma and other autoimmune disorders. We believe that targeting the same pathway in the uterus may help to prevent miscarriage by regulating the fertility window.

"It's an exciting discovery that we hope will mean new developments for a group of women for who there isn't currently any help."


'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo Clinic researchers find new molecule to target in pancreatic cancer treatment
2. Researchers zero in on cognitive difficulties associated with menopause
3. Medical Researcher Examines Alternatives to Major Surgery
4. Common data determinants of recurrent cancer are broken, mislead researchers
5. Researchers identify an early predictor for glaucoma
6. Neurostimulation Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
7. Coffee & Snack Shops in the US Industry Market Research Report Now Available from IBISWorld
8. A Booster Plan for Research Writing, Editing and Consultation by Dissertation Help Asia
9. A Feinstein Institute for Medical Research Study Shows Early Cognitive Problems among Those Who Eventually Get Alzheimer's
10. Biosimulation Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
11. Research Reveals Why Flu Peaks in Certain Seasons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The Dan Carlisle Agency, an ... County, is announcing the launch of a charity drive to raise support and ... women and children in Birmingham has grown steadily since the 1980’s, and the ...
(Date:12/8/2016)... Louis, MS (PRWEB) , ... December 08, 2016 , ... ... that serve commercial and residential clients in and around the Hancock County area, is ... for the Hancock County Food Pantry. , The Hancock County Food Pantry has worked ...
(Date:12/7/2016)... ... December 07, 2016 , ... DrugDev again demonstrated its dedication to ... of the early adopters completing EU-U.S. Privacy Shield Certification from the U.S. Department of ... both sides of the Atlantic with a mechanism to comply with EU data protection ...
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare lighting ... MPCNGX is a multi-function, sealed, LED luminaire that meets the needs of everyone in ... it’s needed. , A 2’ x 4’ model features four modes: reading, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... Smart Device Remote Control through a new partnership with Splashtop Inc. This remote ... its mobile solutions to help businesses maximize their uptime and productivity. , Wavelink ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) has ... 2016 Top Workplaces National Standard. To learn ... ... (PRNewsFoto/Diplomat Pharmacy, Inc.) ... an employee survey administered by WorkplaceDynamics, LLC, a research firm specializing ...
(Date:12/8/2016)... 8 de dezembro de 2016  A Mederi Therapeutics Inc . anunciou ... tratamento não cirúrgico para a doença do refluxo gastroesofágico (DRGE). Foto ... ... Live Stretta procedure performed and broadcast during the ... Wuhan Union Hospital ...
(Date:12/8/2016)... DANVILLE, Pa. , Dec. 8, 2016  A ... physicians reports that the use of opioid therapy to ... actually increase the likelihood of more harmful consequences, including ... Davis , M.D., and Zankhana Mehta , M.D., ... current research on chronic opioid therapy. The study was ...
Breaking Medicine Technology: