Navigation Links
Research shows that a prolonged fertility window can cause recurrent miscarriage
Date:1/4/2013

Researchers at Warwick Medical School have discovered that recurrent pregnancy loss can be due to a dysfunctional monthly fertility window. The study, led by Professor Jan Brosens and Professor Siobhan Quenby of the Division of Reproductive Health, sheds new light on the mechanisms that determine the timing and duration of the fertility window and how that may increase the chances of miscarriage.

The release of the cytokine IL-33 and the activation of its receptor (ST2) in cells in the uterus induces an inflammatory response that controls the stage that we are familiar with as the two to three days of peak fertility.

Work at the Clinical Sciences Research Laboratories at University Hospital, Coventry, showed clearly that in patients with a record of recurrent pregnancy loss, this inflammatory response was prolonged. When the fertility window remains open too long, embryos implant out-of-phase into an environment that cannot support the pregnancy, which leads to miscarriage.

Professor Quenby explained what this discovery means for those who suffer from persistent pregnancy loss, "The study fundamentally changes our understanding of the issue with far reaching clinical implications. The IL-33/ST2 pathway is already considered to be a major target for therapeutic interventions across Alzheimer's, cardiovascular disease, obesity, asthma and other autoimmune disorders. We believe that targeting the same pathway in the uterus may help to prevent miscarriage by regulating the fertility window.

"It's an exciting discovery that we hope will mean new developments for a group of women for who there isn't currently any help."


'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo Clinic researchers find new molecule to target in pancreatic cancer treatment
2. Researchers zero in on cognitive difficulties associated with menopause
3. Medical Researcher Examines Alternatives to Major Surgery
4. Common data determinants of recurrent cancer are broken, mislead researchers
5. Researchers identify an early predictor for glaucoma
6. Neurostimulation Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
7. Coffee & Snack Shops in the US Industry Market Research Report Now Available from IBISWorld
8. A Booster Plan for Research Writing, Editing and Consultation by Dissertation Help Asia
9. A Feinstein Institute for Medical Research Study Shows Early Cognitive Problems among Those Who Eventually Get Alzheimer's
10. Biosimulation Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
11. Research Reveals Why Flu Peaks in Certain Seasons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal ... Friday, November 3, 2017, beginning at 7:00 a.m. (CDT) ... a.m. (CDT) / 9:30 a.m. (EDT). In ... guidance for 2018, Hill-Rom executives will also highlight the ... long-range financial outlook through 2020. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
Breaking Medicine Technology: