Navigation Links
Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Date:1/7/2014

CINCINNATIUniversity of Cincinnati (UC) Cancer Institute researchers have found that using therapies specifically targeting the molecular profile of non-small-cell lung cancer with the mutated cancer-causing protein KRas is the most effective treatment strategy for patients with the condition.

These findings are being presented via poster at the American Association for Cancer Research International Association for the Study of Lung Cancer Joint Conference on the Molecular Origins of Lung Cancer, Jan. 6-9, 2014, in San Diego.

Non-small-cell lung cancer is any type of lung cancer other than small-cell lung cancerthe most common type of lung cancer. Non-small-cell lung cancer with KRas mutation is non-druggable, and no successful targeted therapy currently exists to help patients with this form of lung cancer.

Nagla Karim, MD, PhD, a member of the institute, assistant professor in the division of hematology oncology at the UC College of Medicine, UC Health physician and principal investigator on this study, says researchers assessed the molecular profiling and sensitivity to the KRas mutant lung cancer in comparison with the wild type, or non-mutant, lung cancer.

"Recent studies suggest that patients with KRas-mutant non-small-cell lung cancer do not often benefit from standard systemic therapies and do not respond to epidermal growth factor receptor inhibitors, which are used to control the progression of cancer," she says.

"There is a need for therapies specifically developed for these patients, and molecular profiling has the potential to identify possible targets that might provide better treatment and innovative targeted therapy for KRas-mutated non-small-cell lung cancer."

The mutation of a KRas gene is an essential step in the development of many cancers, including non-small-cell lung cancer.

In the study, researchers purified RNA from banked tumor and normal lung tissue obtained from 20 pati
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Monoclonal Antibodies Market in Gastric and Esophageal Cancers to Reach USD 766 Mln by 2019, Says GBI Research in Its Report Available at MarketPublishers.com
2. Water Treatment Chemicals Procurement Research Report Now Available from IBISWorld
3. Hair Loss Treatment and Removal in the US Industry Market Research Report from IBISWorld Has Been Updated
4. Researchers report technique that enables patient with word blindness to read again
5. Research into fruit fly cells could lead to cancer insights
6. Virginia Tech researchers find novice teen drivers easily fall into distraction, accidents
7. US global share of research spending declines
8. Anesthetic Drugs Procurement Research Report Now Available from IBISWorld
9. Herpes Cure Research
10. One Minute Herpes Cure Review Can Help People Get Rid Of Their Herpes Quickly And Naturally - abb2u.com
11. Hyper Gain Black: Review Exposes New Supplement Created by A.S. Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... December 26, 2014 It is said that ... dress. Today, UWDress.com, the famous wedding dress supplier, shows ... a site-wide cocktail gown promotion. , UWDress.com’s navy cocktail ... and they come in high fashion styles. Simple dresses in ... on the occasion; they are specially designed for those who ...
(Date:12/26/2014)... Aliso Viejo, California (PRWEB) December 26, 2014 ... have announced the TransPack Volume 5 Plugin for Final Cut ... to manipulate a hard light tool to pull off an ... Studios. “When users get their hands on TransPack Volume 5, ... TransPack Volume 5 is a set of over 50 Final ...
(Date:12/26/2014)... 2014 DW-InductionHeating.com (DaWei Induction Heating Co.) ... and developing, producing and marketing of a series of ... announces their new series of induction brazing equipments ... company, induction brazing refers to the joining ... material and heat. The manager says that there are ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... months the trends for evening dresses shift and ... of the hottest styles in the next few months.” The ... 26 A-line sweetheart evening dresses, and announces the availability of ... trying our best to help a lady to show off ... prices, we provide discounted delivery costs to our customers worldwide. ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2
... , PRINCETON, N.J., Sept. 9 ... disease, today announced the completion of patient enrollment in its Phase ... lead drug candidate Pyridorin(TM) (pyridoxamine dihydrochloride ) in type 2 ... (317) patients have been randomized. , , ...
... , , , ... today announced the accelerated development of a Flu A (Influenza Virus) ... be designed to provide 45-minute identification of Flu A infection, with ... strain types. Following review of the Request for Consideration for Emergency ...
... 9 /PRNewswire-FirstCall/ - (OTCBB: GVBP.OB) - GENova Biotherapeutics, Inc., ... development strategy and its unique niche in the drug ... involving the latest generation of biotherapeutic technologies that can ... focus on prostate and breast cancers, GENova has acquired ...
... , , , ... (Pink Sheets: FTER), which, through its ABTTC Inc. division provides ... healthcare services with the highest levels of accreditation, announced today ... of its "A Better Tomorrow" facility, and Jim Fent, Executive ...
... ... Reference Center™ and Patient Education Reference Center™ Available online at www.ebscohost.com/flu . ... , ... September 9, 2009 -- Concerns about Pandemic H1N1 and the upcoming flu season have ...
... , ... and Cosmetic Dentistry, well known for dental care as well as cosmetic and sedation ... , ... September 9, 2009 -- Raleigh Comprehensive and Cosmetic Dentistry, led by Dr. Robert L. ...
Cached Medicine News:Health News:NephroGenex Announces Full Enrollment in New Pyridorin(TM) Clinical Trial - PYR 210 2Health News:Cepheid Announces Accelerated Development of Flu A Panel Test 2Health News:Cepheid Announces Accelerated Development of Flu A Panel Test 3Health News:Cepheid Announces Accelerated Development of Flu A Panel Test 4Health News:GENova discusses development of new anti-cancer biotechs potentially worth $400 Million per annum 2Health News:GENova discusses development of new anti-cancer biotechs potentially worth $400 Million per annum 3Health News:Forterus Inc. Executives to Be Interviewed on VoiceAmerica 2Health News:EBSCO Publishing Makes Evidence-Based Flu Resources Freely Available 2Health News:EBSCO Publishing Makes Evidence-Based Flu Resources Freely Available 3Health News:Raleigh Comprehensive and Cosmetic Dentistry Announces Addition of New Practice to Raleigh Dentist Family 2
(Date:12/24/2014)... DIEGO , Dec. 23, 2014 ResMed (NYSE: ... significant patent infringement action against Chinese medical device manufacturer BMC ... (ITC) ruled today that BMC,s masks listed below infringe ResMed,s ... or selling these masks in the United States ... iVolve N2 nasal mask , Willow nasal pillows mask ...
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation ... its CytoSorb® blood purification technology to help fight ... in 28 countries worldwide, today announced the appointment ... MD, FACS, as its Senior Vice President of ... Dr. Di Russo is an ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... Depomed, Inc. (NASDAQ: DEPO ) today ... payment from Ironwood Pharmaceuticals, Inc. following the development and ... candidate meeting pre-specified attributes under its Research Collaboration and ... in July 2011. Under the terms of the agreement, Depomed ...
... China, May 11, 2012 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group ... a leading pharmaceutical company specializing in the development, manufacturing, ... today announced that the annual general meeting of shareholders ... 2012 at 10 a.m. Beijing time. The meeting will ...
Cached Medicine Technology:Depomed Announces Receipt of $1 million Milestone Payment From Ironwood Pharmaceuticals, Inc. 2Simcere Pharmaceutical Group Provides Notice of Annual General Meeting 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: