Navigation Links
Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Date:1/7/2014

CINCINNATIUniversity of Cincinnati (UC) Cancer Institute researchers have found that using therapies specifically targeting the molecular profile of non-small-cell lung cancer with the mutated cancer-causing protein KRas is the most effective treatment strategy for patients with the condition.

These findings are being presented via poster at the American Association for Cancer Research International Association for the Study of Lung Cancer Joint Conference on the Molecular Origins of Lung Cancer, Jan. 6-9, 2014, in San Diego.

Non-small-cell lung cancer is any type of lung cancer other than small-cell lung cancerthe most common type of lung cancer. Non-small-cell lung cancer with KRas mutation is non-druggable, and no successful targeted therapy currently exists to help patients with this form of lung cancer.

Nagla Karim, MD, PhD, a member of the institute, assistant professor in the division of hematology oncology at the UC College of Medicine, UC Health physician and principal investigator on this study, says researchers assessed the molecular profiling and sensitivity to the KRas mutant lung cancer in comparison with the wild type, or non-mutant, lung cancer.

"Recent studies suggest that patients with KRas-mutant non-small-cell lung cancer do not often benefit from standard systemic therapies and do not respond to epidermal growth factor receptor inhibitors, which are used to control the progression of cancer," she says.

"There is a need for therapies specifically developed for these patients, and molecular profiling has the potential to identify possible targets that might provide better treatment and innovative targeted therapy for KRas-mutated non-small-cell lung cancer."

The mutation of a KRas gene is an essential step in the development of many cancers, including non-small-cell lung cancer.

In the study, researchers purified RNA from banked tumor and normal lung tissue obtained from 20 patients with wild-type and 17 patients with mutant-type KRas non-small-lung cancer tumors which were being removed in stages I and II.

"We assessed the expression of four genes involved in cell synthesis and repair, and our results show that in mutant-type KRas tumors, the levels of expression of several of three of the genes (BRCA1, TS and SRC) were significantly increased in comparison to normal lung tissue," Karim says. "The expression of the same genes was significantly increased in wild-type KRas tumors relative to their expression in normal lung.

"Interestingly, SRC expression in mutant-type KRas tumors was decreased in comparison to wild-type KRas tumors. These findings suggest that greater expression of the gene ERCC1 in mutant KRas tumors might increase platinum-based chemotherapy resistance in this group of patients, whereas the greater expression of the BRCA1 in wild KRas tumors might suggest sensitivity to taxanes, which are chemotherapy agents."

She adds that this data also suggests that the combination of an approved SRC inhibitor with a TS inhibitor might improve the outcome of patients with wild-type KRas tumors.

"These results shed new light on potentially more effective treatment strategies for patients with various types of KRas-related non-small-cell lung cancer," she says. "We hope that these findings will lead to better therapies and improved outcomes for patients."


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Monoclonal Antibodies Market in Gastric and Esophageal Cancers to Reach USD 766 Mln by 2019, Says GBI Research in Its Report Available at MarketPublishers.com
2. Water Treatment Chemicals Procurement Research Report Now Available from IBISWorld
3. Hair Loss Treatment and Removal in the US Industry Market Research Report from IBISWorld Has Been Updated
4. Researchers report technique that enables patient with word blindness to read again
5. Research into fruit fly cells could lead to cancer insights
6. Virginia Tech researchers find novice teen drivers easily fall into distraction, accidents
7. US global share of research spending declines
8. Anesthetic Drugs Procurement Research Report Now Available from IBISWorld
9. Herpes Cure Research
10. One Minute Herpes Cure Review Can Help People Get Rid Of Their Herpes Quickly And Naturally - abb2u.com
11. Hyper Gain Black: Review Exposes New Supplement Created by A.S. Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: