Navigation Links
Research shows how pathogenic bacteria hide inside host cells
Date:1/26/2011

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

Staphylococcus aureus is a major human pathogen which can be carried by up to 70% of healthy people, and can lead to conditions such as deep tissue infections, osteomyelitis, and chronic lung infections, which are often hard to treat with antibiotics. A key characteristic of these infections is that relapses can occur months or years after an apparent cure.

These relapses, Dr. Bettina Lffler and her team from the Institut fr Medizinische Mikrobiologie in Mnster, Germany, believe are due to phenotype switching, a change in the bacterial behaviour. After infection and invasion of the patient's host cells, the bacteria form small colony variants (SCVs), tiny bacterial subpopulations that can evade the immune system as well as many antibiotics and grow slowly.

"For the microbiologist, it is difficult to detect SCVs in clinical specimens as they grow slowly, often needing several days to form and so can be easily overlooked in diagnosis," said Lffler. "Our study asked two questions: Is the development of SCVs an integral part of the infection process and what are the dynamics of SCV formation?"

The team performed long-term infection studies with Staphylococcus aureus in cell culture systems and also analysed tissue samples from subacute and chronic human infections.

The research revealed that in all infection models, the bacteria were able to persist within the host for several weeks after the infection, leading to the formation of SCV colonies. This showed that SCVs began to appear following infection, after the immune system response was overcome and that this persistence led to a larger phenotypic diversity of bacteria.

"These studies demonstrate that S. aureus are extreme versatile microorganisms that continuously sense their environmental conditions and can rapidly alter to reflect them," said Lffler. "The formation of SCV colonies is a bacterial phenotype switching strategy which is an integral part of the infection process."

This process enables the bacteria to hide inside host cells without provoking an inflammatory response from the host's immune system. In addition, they might be efficiently protected from antibiotic treatment.

"This strategy means that SCVs can be considered as 'dormant forms' of infections which can rapidly regain their full virulence and cause a patient to relapse," concluded Lffler. "This has important clinical implications as it means that targeting phenotype switching could prevent the bacteria from hiding, making the infection more vulnerable to host response and treatment."


'/>"/>

Contact: Ben Norman
Lifesciencenews@wiley.com
44-012-437-70375
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to take ... an inventor from Austin, Texas, has identified a solution. , She developed a prototype ... restricted lighting. As such, it eliminates the need to turn on a light when ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of ... collection of specialty vendors and unique items from across the nation, this holiday-themed event ... wellness services offered by the VNA. The boutique will be open Saturday, November ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
Breaking Medicine Technology: