Navigation Links
Research shows how genetic mutation causes epilepsy in infants
Date:10/3/2007

New research from the Howard Florey Institute in Melbourne has shown why mutation in a single gene can cause epilepsy in infants.

Infants are more susceptible to seizures because their brains are developing at a rapid rate, making their brain cells excitable. Their neurons are growing and making new connections with other nerve cells, which can disrupt normal brain activity and results in epilepsy.

Infants have protective mechanisms in their brains to control this excitability, but now the Florey scientists have uncovered that a single gene mutation prevents a specific ion channel from functioning correctly, thus causing excitability which results in epilepsy.

Dr Steven Petrou and his team knew the genetic mutation existed, but did not know its impact on brain function or that it may control excitability in infants brains.

This discovery is helping us to understand how and why this form of epilepsy, known as benign familial neonatal-infantile seizures, appears in these infants, Dr Petrou said.

Interestingly, we also found that the ion channel which carries the mutation is itself naturally protective as it limits excitability in the infant brain by waiting to fully switch on only in the adult brain.

The mutation accelerates this normally delayed development change, leaving the susceptible infant brain with an overly excitable channel and epilepsy.

If this switch to a more excitable state occurs too early during brain development, it is possible that epilepsy and other neurological disorders develop.

This highlights the complexity of the human brain and how disorders can develop if one single mechanism goes awry, he said.

This research was recently published in Molecular and Cellular Neuroscience. According to Dr Petrou, potential new avenues of research may emerge from this study.

Epilepsy affects 3% of the Australian population and better treatments are urgently needed as
'/>"/>

Contact: Merrin Rafferty
merrin.rafferty@florey.edu.au
61-400-829-601
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Stem cell research- now Nobel Laureates join the debate
3. Researchers urge caution in using ear tube surgery
4. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
5. Spouses and other partners lower blood pressure says new research
6. Researchers Scale to assess the Severity of Epilepsy in Kids
7. More Research Required For COPD
8. Researchers identify the early makers of Neonatal Sepsis
9. OHSU Researchers Announce New Discovery
10. Skin Cancer Research To Go Global
11. Researchers Identify Gene Connected To Bipolar Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... July 23, 2014 The age spots, wrinkles ... over the age of 30 are now explored in a ... the best eye creams for women over 30 are introduced ... http://cherrynews.com/best-nourishing-eye-serum . , The use of creams as an ... partly based on cost, according to the information in the ...
(Date:7/23/2014)... Edmond, Oklahoma (PRWEB) July 23, 2014 ... North America’s leading provider of in-home care for ... Healthy Longevity Webinar Series featuring experts in a ... upcoming webinar will feature licensed clinical social worker ... the most common causes of caregiver stress and ...
(Date:7/23/2014)... NY, July 24, 2014) If past experience is ... State are about to get a lot more recognition ... already on the books allowing NPs to provide primary ... patient care and better relationships with physicians and administrators, ... study from Columbia University School of Nursing, published in ...
(Date:7/23/2014)... Celebrating a decade of philanthropy in 2014, ... awarding of $1,070,000 in grants to 20 New Jersey ... the Foundation’s 1,000th grant. , “The Horizon Foundation for ... supporting community-based organizations that are working to improve public ... Garden State,” said Robert A. Marino, Horizon Blue Cross ...
(Date:7/23/2014)... growing body of research suggesting a safe and ... postmenopausal breast cancer, with fewer detrimental side effects ... therapies. The study will be published in final ... Biology and Endocrinology . , Breast cancer is ... the United States. Approximately 70% of breast cancers ...
Breaking Medicine News(10 mins):Health News:Best Eye Creams for Women Over 30 Detailed in Published Guide at News Website Online 2Health News:Oklahoma Home Care Assistance Hosting Caregiver Mindfulness Webinar Tomorrow 2Health News:Oklahoma Home Care Assistance Hosting Caregiver Mindfulness Webinar Tomorrow 3Health News:New York law offers nurses more recognition, responsibility 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5
... MINNEAPOLIS, Oct. 17 Health Fitness Corp.,(OTC Bulletin Board: ... results for the third quarter ended September 30,2007, on ... Company also,announced that it will hold a conference call ... call will be Dr. Gregg Lehman, President and,Chief Executive ...
... Fla., Oct. 17 "As a physician,you hear all ... says Dr. Terry,D. Hashey, Medical Director of First Coast ... Corral Flu Campaign.,The most common that Dr. Hashey reports ... the flu shot. "That couldn,t be farther from the ...
... outcomes at Houston Northwest Medical ... nation,s best for several service lines, HOUSTON, ... Hospital Quality in America Study issued today, Houston,Northwest ... service,lines including overall gastrointestinal services, gastrointestinal,surgery, stroke, general ...
... that hospital-caused MRSA infections are about triple, previous estimates. The Centers ... and have failed to call on hospitals to take the ... ... infections., NEW YORK, Oct. 17 Today, data in an article,published ...
... WEST CHESTER, Ohio, Oct. 16 AtriCure, Inc.,(Nasdaq: ... leader in cardiac surgical,ablation products, today announced that ... which physicians have adopted to,treat atrial fibrillation (AF), ... Dr. James H. McClelland, an,electrophysiologist, and colleagues from ...
... breast cancer drugs called taxanes, which include Taxol (paclitaxel) ... part of chemotherapy following surgery for cancers that have ... research. , The review, which compared chemotherapy regimes ... studies including 21,191 women. , For patients, this study ...
Cached Medicine News:Health News:Health Fitness Corp. to Report Third Quarter 2007 Financial Results on November 5, 2007 2Health News:Flu Myths Abound in Flu Season 2Health News:Houston Northwest Medical Center's Patient Outcomes Superior 2Health News:Houston Northwest Medical Center's Patient Outcomes Superior 3Health News:The Journal of the American Medical Association (JAMA) Article Reveals Scope of MRSA Infections 2Health News:Published Results Using AtriCure Minimally Invasive Products 2Health News:Published Results Using AtriCure Minimally Invasive Products 3Health News:Taxol-type drugs give slight boost to survival rates in early breast cancer 2Health News:Taxol-type drugs give slight boost to survival rates in early breast cancer 3
(Date:7/23/2014)... 23, 2014  Lightlake Therapeutics Inc. ("Lightlake") (OTCQB: ... on its expertise in opioid antagonists, announced today ... application ("IND") with respect to its naloxone-based opioid ... that it has received an additional commitment from ... of the National Institutes of Health ("NIH"), to ...
(Date:7/23/2014)... , July 23, 2014  Silk Road Medical, ... transcarotid treatment of intra- and extra-cranial cerebrovascular disease, ... Wallace to the position of Chief Technology ... the company,s Research and Development efforts across its ... Prior to joining Silk Road Medical, ...
(Date:7/23/2014)... 2014  ACON Equity Partners III, L.P., a private ... announced it has completed the purchase of Injured Workers ... and Parthenon Capital Partners. IWP is a leading specialty ... Automobile Personal Injury Protection and Personal Injury pharmacy markets ... As part of this transaction, ACON partnered ...
Breaking Medicine Technology:Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 2Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 3Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3ACON Investments Acquires Injured Workers Pharmacy 2ACON Investments Acquires Injured Workers Pharmacy 3
... Jan. 16, 2012 Boston Scientific Corporation (NYSE: ... its ORION trial, demonstrating excellent outcomes for the Company,s ... artery disease, a form of peripheral artery disease associated ... Results were presented today by Daniel Clair, M.D., FACS, ...
... SAN FRANCISCO, Jan. 16, 2012 Dicom Systems ( ... is pleased to announce their selection as the Vendor ... California-based full service physician-owned teleradiology group. ... you have the capacity to turn your current storage ...
Cached Medicine Technology:Boston Scientific Epic™ Stent Demonstrates Positive Clinical Outcomes in Orion Trial 2Boston Scientific Epic™ Stent Demonstrates Positive Clinical Outcomes in Orion Trial 3Boston Scientific Epic™ Stent Demonstrates Positive Clinical Outcomes in Orion Trial 4Boston Scientific Epic™ Stent Demonstrates Positive Clinical Outcomes in Orion Trial 5ONRAD, Inc. Chooses Dicom Systems' Vendor Neutral Archive 2