Navigation Links
Research shows gene-based test can prioritize smokers for lung cancer CT screening
Date:11/9/2010

rcent of the diagnoses will be in current and former smokers, a group now estimated to include 80 million Americans.

But the breakthrough also poses serious medical management dilemmas due to the potential cost of screening millions of smokers and the possible harm of accumulated radiation exposure and false positives from imaging which may, in turn, spur more invasive procedures such as lung biopsies for ultimately non-cancerous lesions. Without better patient targeting, CT screening of smokers or ex-smokers aged 50 and over only picks up cancers in only 1 to 2 percent of those scanned.

"Using Respiragene to prioritize current and former smokers for CT scanning would significantly improve the number of early stage lung cancer cases found per scans administered," said Dr. Young.

About the Research

Researchers used the Respiragene test on 1,216 confirmed lung cancer cases in cohorts gathered in New Zealand, Spain and the United Kingdom. The test incorporates 20 genetic markers associated with smoking-related lung damage and propensity to lung cancer, along with a smoker's age, family history, and diagnosis of chronic obstructive pulmonary disease (COPD) to derive a predictive risk score on a 1-12 scale whereby higher scores correlate with higher lifetime risk of developing lung cancer, compared to other smokers.

In the group analysis, current or former smokers with a Respiragene score of 6 or higher, representing 20 percent of the group, identified more than 50 percent of those with lung cancer. With the test featuring a specificity level over 80 percent (i.e. a false positive rate of only 20 percent), this sub-group is at very high risk of getting lung cancer and would likely gain the most benefit from closer surveillance and active screening, including regular CT scans. By increasing the pick-up rate of lung cancer per number of persons scanned, the cost-effectiveness of CT screening can be substantially impr
'/>"/>

Contact: Ken Li
kli@chempetitive.com
312-532-4675
Chempetitive Group
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers discover important link between adrenal gland hormone and brain in hypertension
2. Fred Hutchinson Cancer Research Center scientist receives Presidential Early Career Award
3. New research shows genetic test for lung cancer risk prompts smokers to quit
4. Hebrew University researchers discover expanded role for cancer-causing gene
5. Common Foot Disorders Can Be Inherited, Research Shows
6. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
7. Research Suggests Link Between Handedness and Dyslexia
8. Breakthrough in cancer vaccine research
9. NTU and A*STAR launch joint Ph.D. research program in immunology
10. Film director launches pioneering hearing research
11. New research shows disparities in hospice enrollment are not likely related to access
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 26, 2014 Plugin and template developers from ... 5 Plugin for Final Cut Pro X. , “TransPack Volume ... tool to pull off an industry professional look” Said Christina ... hands on TransPack Volume 5, a new level of professionalism ... set of over 50 Final Cut Pro X transitions featuring ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... The click strand woven ... and durability. Today, the business announces a click ... until Jan. 30, 2015. , Click strand woven ... BambooFlooringChina.com is a well-known brand in the bamboo ... find a reliable bamboo flooring supplier. , “We ...
(Date:12/25/2014)... 26, 2014 “Every three months the trends ... A-line sweetheart evening dress will be one of the hottest ... of Yunx.co.uk says. Today, the company releases 26 A-line sweetheart ... to 80% off. , “We are trying our best ... with our latest designs. Along with affordable prices, we provide ...
(Date:12/25/2014)... December 25, 2014 Recently, BellasDress ... on all its wedding dresses. BellasDress has chosen their ... for gift choices for the holiday season. , ... pick suitable wedding gowns here at discount prices. The ... experience at its website. , “All our ...
Breaking Medicine News(10 mins):Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... 2 are at increased risk from having respiratory infections,// ... other problems that were already associated with diabetic patients ... lead to blindness, and cardiovascular complications. Body weight increase ... of all types. All persons dealing with the disease ...
... thyroid cancer may be detectable using a blood test ... a study published by researchers at The Ohio ... James Cancer Hospital and Richard J. Solove Research Institute. ... the Journal of Clinical Endocrinology & Metabolism. ...
... can detect twice the number of vaginal cancer and ... finding from researchers at Washington University School of Medicine ... July 1st issue of the ‘International Journal of ... future gold standard for early detection of cancers of ...
... be an indication of how they may be at risk// ... a condition that affects about 10% of the women in ... of male hormones called androgens, with irregular or no menstrual ... their ovaries. The syndrome may affect the women’s health and ...
... New research can now help the clinicians to predict which ... sores, also known as pressure sores or pressure ulcers, affect ... the hospital or at home without much movements. Bedsores arise ... mostly bedridden. About 5-10% of the total patients in the ...
... A 20-year prospective study published in Amercian Journal ... the relation between asthma and panic attack in ... between ages 19 and 40 and information was ... were conducted by trained professionals. At each interview, ...
Cached Medicine News:Health News:Tumour marker for detecting early Recurrence of Thyroid cancer may be soon available 2Health News:PET Scanner detects more Vaginal cancer than CT scans 2
(Date:12/24/2014)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ), ... announce Jennifer Hagerman , Pharm.D., AE-C, senior director ... as the president of the Michigan Pharmacists Association on ... place Feb. 28, 2015, at the MPA Annual Convention ... Center in Detroit, Michigan . Hagerman ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
(Date:12/24/2014)... , Dec. 23, 2014   Synageva ... a biopharmaceutical company developing therapeutic products for rare ... Agency (EMA) of the Marketing Authorization Application (MAA) ... recently granted the company,s request for accelerated assessment, ... regulatory review time.   The MAA, ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... Penile Prosthesis (IPP) is a ... surgically implanted into the penis ... dysfunction (also known as impotence). ... with voluntary control over the ...
... Positionable Penile Prosthesis,The ... prosthesis is made of ... core strength that gives ... most: ease of positioning, ...
... AMS Ambicor is a uniquely designed two-piece ... cylinders implanted in the corpora cavernosa and ... scrotum. Patients simply squeeze the pump to ... the prosthesis. This closed, fluid-filled system allows ...
Only Mentors reusable Alpine Leg Bag has patented Kraylex odor barrier, offset port options, and integrated loops providing total confidence and comfort....
Medicine Products: