Navigation Links
Research shows gene-based test can prioritize smokers for lung cancer CT screening
Date:11/9/2010

rcent of the diagnoses will be in current and former smokers, a group now estimated to include 80 million Americans.

But the breakthrough also poses serious medical management dilemmas due to the potential cost of screening millions of smokers and the possible harm of accumulated radiation exposure and false positives from imaging which may, in turn, spur more invasive procedures such as lung biopsies for ultimately non-cancerous lesions. Without better patient targeting, CT screening of smokers or ex-smokers aged 50 and over only picks up cancers in only 1 to 2 percent of those scanned.

"Using Respiragene to prioritize current and former smokers for CT scanning would significantly improve the number of early stage lung cancer cases found per scans administered," said Dr. Young.

About the Research

Researchers used the Respiragene test on 1,216 confirmed lung cancer cases in cohorts gathered in New Zealand, Spain and the United Kingdom. The test incorporates 20 genetic markers associated with smoking-related lung damage and propensity to lung cancer, along with a smoker's age, family history, and diagnosis of chronic obstructive pulmonary disease (COPD) to derive a predictive risk score on a 1-12 scale whereby higher scores correlate with higher lifetime risk of developing lung cancer, compared to other smokers.

In the group analysis, current or former smokers with a Respiragene score of 6 or higher, representing 20 percent of the group, identified more than 50 percent of those with lung cancer. With the test featuring a specificity level over 80 percent (i.e. a false positive rate of only 20 percent), this sub-group is at very high risk of getting lung cancer and would likely gain the most benefit from closer surveillance and active screening, including regular CT scans. By increasing the pick-up rate of lung cancer per number of persons scanned, the cost-effectiveness of CT screening can be substantially impr
'/>"/>

Contact: Ken Li
kli@chempetitive.com
312-532-4675
Chempetitive Group
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers discover important link between adrenal gland hormone and brain in hypertension
2. Fred Hutchinson Cancer Research Center scientist receives Presidential Early Career Award
3. New research shows genetic test for lung cancer risk prompts smokers to quit
4. Hebrew University researchers discover expanded role for cancer-causing gene
5. Common Foot Disorders Can Be Inherited, Research Shows
6. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
7. Research Suggests Link Between Handedness and Dyslexia
8. Breakthrough in cancer vaccine research
9. NTU and A*STAR launch joint Ph.D. research program in immunology
10. Film director launches pioneering hearing research
11. New research shows disparities in hospice enrollment are not likely related to access
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Indosoft, Inc. , a leading provider of scalable ... most advanced contact center product, Q-Suite 5.7.7. This ... as updates to existing aspects of its popular ... presentation side has received an update with the incorporation ... This WYSIWYG editor allows admins to easily add advanced ...
(Date:8/29/2014)... Denver, Colorado (PRWEB) August 29, 2014 ... perfect body is never easy. , According to ... dreamed body might be simpler than imagined with the ... reveals that Shapeshifter Yoga can be an amazingly effective ... Yoga review indicates that this new program is really ...
(Date:8/29/2014)... 29, 2014 Daily Gossip reveals in its ... a new method of naturally curing this disease. , ... to a permanent cure in only one week. This is ... need to make huge sacrifices. , Moreover, with this ... the symptoms of sciatica in just 8 minutes. , ...
(Date:8/29/2014)... Los Angeles, CA (PRWEB) August 29, 2014 ... site that connects the industry’s most notable plastic ... recommended doctors that write about cutting edge techniques ... checked to ensure they contain the most reliable ... select the right cosmetic treatment.     , Cosmetic Town ...
(Date:8/29/2014)... August 29, 2014 The Department of ... final rule (file code CMS–0052–P) today allowing healthcare providers ... 2011 Edition Certified EHR Technology (CEHRT) or a combination ... (EPs) who have not been able to fully implement ... in 2014 can continue to use 2011 Edition CEHRT, ...
Breaking Medicine News(10 mins):Health News:Indosoft Releases Q-Suite 5.7.7 2Health News:Shapeshifter Yoga Review Reveals Kris Fondran's New Body Shaping and Fat Loss Program 2Health News:Stop Sciatica in 8 Minutes Review Exposes Steven Guo's Complete Sciatica Cure 2Health News:Cosmetic Town Is Now Connecting Patients with Qualified Cosmetic Specialists 2Health News:Quirk Healthcare Outlook on MU2 Delay Confirmation 2
... fuel consumption besides the deleterious effects it has on health.// ... 940 million more gallons of gas into their vehicles than ... now become roughly two dozen pounds heavier which amounted to ... at $3 for a gallon of gas. ,These ...
... reasons to prove that two migratory birds, the common wood ... vulnerable and prone to infection with the highly virulent H5N1 ... the deadly bird flu. ,In an effort to ... Avian flu which had most parts of the world reeling ...
... Food and Drug Administration gave its approval for Tyzeka ... treatment of chronic Hepatitis B// (HBV). Clinical studies have shown ... is usually well tolerated. ,Hepatitis B is a ... every year. It is a serious illness and around 5000 ...
... study published on Tuesday, the younger brains of teens ... ,However, the researchers found that this enhanced ... that could result in permanent damage to the under-developed ... rats as substitutes for teen drinkers.,The previous studies by ...
... Advisory Committee on Immunization Practices has made the recommendation on ... zoster) virus.// ,The vaccine is called Zostavax (Merck& ... May. It has a live virus several times more potent ... ,Shingles is an extremely painful rash caused by the ...
... Maputo – Trials for the malaria vaccine are underway in ... vaccine in the market by 2010. The production// of the ... deputy health minister, Aida Libombo, while addressing a gathering of ... be available by 2010 if the tests in Manhica (north ...
Cached Medicine News:Health News:Brain development in teens curbed by alcohol tolerance 2
(Date:8/29/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... the District of New Jersey ... against Sandoz, Inc. regarding United Therapeutics, Remodulin ® ... that U.S. Patent No. 6,765,117 is both valid and ... its generic product until the expiration of that patent ...
(Date:8/29/2014)... 2014 Diseases largely eradicated in ... returning. Measles was declared eliminated in 2000, yet the ... August 15—the highest incidence in 20 years. In July, ... whooping cough a problem of "epidemic proportions." ... dying from these preventable diseases—in part because some parents ...
(Date:8/29/2014)... Research and Markets has announced ... Market 2014-2018" report to their offering. ... that results in demyelination, axonal transection, and neurodegeneration. The ... by the immune system, which targets neurons within the ... disease in which the damage of the myelin sheath ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... 9, 2011 /PRNewswire-USNewswire/ – CoMeD – On Friday, May ... filed an amendment to regulate vaccines containing mercury in ... buy, sell, manufacture, deliver, import, administer or distribute any ... or inorganic mercury per milliliter for children younger than ...
... 2011 Kinex Pharmaceuticals, LLC announced today that Dr. Allen ... decided to step aside as CEO. Dr. ... from a start-up biotechnology company with only a technology platform ... pre-IND to phase 2 developments. The recent collaboration established with ...
Cached Medicine Technology:Florida Legislature Refuses to Limit Mercury in Vaccines 2Florida Legislature Refuses to Limit Mercury in Vaccines 3The Board of Directors of Kinex Pharmaceuticals Appoints Dr. Allen Barnett as President Emeritus and Dr. Johnson Lau as Chief Executive Officer 2The Board of Directors of Kinex Pharmaceuticals Appoints Dr. Allen Barnett as President Emeritus and Dr. Johnson Lau as Chief Executive Officer 3
Our high quality therapeutic drug monitoring reagents, calibrators and controls are available for most chemistry analyzers. Reproducible and accurate results for your laboratory needs....
Revised Drug calibrator that replaces existing Drug calibrator - this product contains Lithium in addition to Digoxin, Phenobarbital, OPhenytoin, & Theophulline....
Liquichek Rheumatoid Factor Control is a liquid trilevel control designed to monitor rheumatoid factor testing procedures, including nephelometric and latex agglutination methods....
... BD Macro-Vue RPR (Rapid Plasma Reagin) ... Tests are nontreponemal testing procedures for ... in A Manual of Tests for ... manual are the most widely used ...
Medicine Products: