Navigation Links
Research shows early promise of new drug for cancers caused by viruses
Date:1/14/2014

New Orleans, LA Christopher Parsons, MD, Director of the HIV Malignancies Program at LSU Health Sciences Center New Orleans, is the senior author of a paper that is the first to report that specialized fat (lipid) molecules, called sphingolipids, play a key role in the survival of aggressive lymphomas caused by viruses. The paper also reveals a new therapy for preventing production of sphingolipids by lymphoma cells, thereby killing these cells, which are often resistant to standard therapies. The study is published in the January 2014 issue of Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

The research team focuses on primary effusion lymphoma (PEL), an aggressive and deadly variant of diffuse large B-cell lymphoma that frequently occurs in people infected with HIV. Though scientists have known that the Kaposi's sarcoma-associated herpesvirus (KSHV) causes PEL, development of effective therapies has proven difficult. PEL tumors arise within body cavities and progress rapidly with an average survival of around 6 months. Combination chemotherapy represents the current standard of care for PEL, but side effects (including bone marrow suppression) and drug resistance (generated through virus-associated mechanisms) continue to limit the effectiveness of standard therapy.

After documenting the role of an enzyme called sphingosine kinase (SK), in the generation of biologically active sphingolipids in PEL tumors that keep the tumor cells alive, the researchers tested a novel clinical-grade small molecule that selectively targets SK. The molecule, called ABC294640, was developed by Apogee Biotechnology Corporation. Previous studies found antitumor effects for ABC294640 with kidney, prostate, and breast cancer cell lines. In the current study, ABC294640 not only inhibited SK function and induced PEL cell death, it worked selectively for virus-infected cells while sparing uninfected cells.

"It is still ea
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UNC researchers harness suns energy during day for use at night
2. T-cell research sheds light on why HIV can persist despite treatment
3. Global Medical Publishing Market 2014-2018: Worldwide Industry Share, Investment Trends, Growth, Size, Strategy and Forecast Research Report
4. Research for Her TM, an online clinical research registry, honored with distinguished national award
5. Its all coming back to me now: Researchers find caffeine enhances memory
6. Personalized Medicine in Oncology Partnering Terms and Agreements, a New Research Report at ReportsnReports.com
7. Eye Glasses & Contact Lens Stores in the US Industry Market Research Report from IBISWorld Has Been Updated
8. Global Ostomy Care Industry Trend & 2017 Opportunities Analyzed in New Research Study at MarketReportsOnline.com
9. China Digital Radiography Industry & Global CBCT Market Analysis in a New Research Study Available at DeepResearchReports.com
10. Loyola receives Innovation Award for clinical research database
11. CardioWise™ Completes Small Business Innovation and Research Grant from the National Science Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 For over 20 years, Dr. David Cruz ... Vista area has treated just about every type of injury ... And for those same twenty-plus years, the team at ... injuries with the best possible doctor. With the combined ...
(Date:1/22/2015)... NY (PRWEB) January 22, 2015 ... of Sports Medicine flagship journal Medicine & Science ... L-Citrulline before exercise may help reduce gastrointestinal (GI) ... 1 , Participants in the double-blind, placebo-controlled ...
(Date:1/22/2015)... Palm City, Florida (PRWEB) January 22, 2015 ... use cold therapy machine with patented IsoTube design to treat ... has introduced the most progressive and easy to use ... help treat post-operative and sports related orthopedic and muscle injuries. ...
(Date:1/22/2015)... 22, 2015 EBSCO Information Services ... expanding their relationship in an effort to further promote visibility ... While EBSCO has long made AMA journals available via its ... for The JAMA Network. , Long known as ...
(Date:1/22/2015)... released a new blog post presenting a list of vehicles that ... , Some types of vehicles cannot be covered under an ordinary ... to see if their vehicle qualifies for auto insurance coverage. ... cars that cannot be covered by a plan. Clients have little ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... practice of her father in 2004, Dr. Ann Fishel has spent nearly ... a team approach to dentistry, Dr. Fishel is making a name for ... ... April 18, 2009 -- While many people become nervous and fearful at ...
... INCLUDING PUBLIC PLAN AND SOME TAX CHANGES But Argument ... Actual DebateMENLO PARK, Calif., April 23 As economic ... to say that they or a member of their ... past year, according to the Kaiser Family Foundation,s April ...
... DENVER, April 22 Cambridge Research & ... Slide Analysis System at the 100th Annual ... Research (AACR) in Denver. The Vectra system ... fluorescence-capable solution for rapidly generating high-resolution cellular ...
... Gates Foundation welcomes today,s news that the UK Government will ... world, despite the current economic downturn, and achieve the EU ... Income by 2010. "The UK government,s pledge to increase the ... time will contribute to real progress in the fight against ...
... Hospice and Palliative Care Organization Welcomes 1,600 Professionals to ... and palliative care leaders, managers and industry experts have ... healthcare reform a major topic of concern."Almost 30 percent ... last year of life, with an estimated 30 percent ...
... Starting in January 2010, as much as 40 ... electricity will come from wind turbines in eastern ... Care signed a nine-year agreement with Iberdrola ... million kilowatt hours of electricity annually from Iberdrola Renewables, ...
Cached Medicine News:Health News:Up-and-Coming Houston Cosmetic Dentist Soon to Mark 5 Years Working with Family at a Family Dental Practice 2Health News:Up-and-Coming Houston Cosmetic Dentist Soon to Mark 5 Years Working with Family at a Family Dental Practice 3Health News:Six in Ten Say Family Put Off Medical Care Due to Cost 2Health News:Six in Ten Say Family Put Off Medical Care Due to Cost 3Health News:Six in Ten Say Family Put Off Medical Care Due to Cost 4Health News:Six in Ten Say Family Put Off Medical Care Due to Cost 5Health News:Six in Ten Say Family Put Off Medical Care Due to Cost 6Health News:CRi's New Vectra(TM) Platform Rapidly Analyzes Tissue Slides and Microarrays in Brightfield and Fluorescence 2Health News:Bill & Melinda Gates Foundation Commends UK Government for Maintaining Its Commitment to the World's Poor 2Health News:Hospice Palliative Care Leadership Conference Kicks Off with Focus on Healthcare Reform and the Release of New Pediatric Standards of Care 2Health News:Christiana Care Health System to Purchase Wind Power 2
(Date:1/22/2015)... 22, 2015  BiOptix is pleased to announce the appointment ... of Chemistry and Biochemistry. Scott joins the company after previous ... Amgen throughout the course of his nearly 20 year ... is a nationally recognized thought leader in the biosensor ...
(Date:1/22/2015)... Jan. 22, 2015  Amgen (NASDAQ: AMGN ) today announced ... financial results on Tuesday, Jan. 27, 2015, after the close of ... conference call with the investment community at 2 p.m. PT. Participating ... , chairman and chief executive officer, and other members of Amgen,s ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ( ... "Infectious Disease Diagnostics Market by Product, Application, Technology, End ... their offering. , The infectious disease diagnostics ... to reach $18,156.2 million by 2019 from $12,422.8 million ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
... Company Also Receives Patent Covering ARIKACE for Once-Daily Treatment ... N.J., June 25 Cystic Fibrosis Foundation Therapeutics Inc., ... provided a $2.2 million award to Transave Inc., for ... an antibiotic that aims to treat Pseudomonas ...
... a revolutionary healthcare finding, a peer-reviewed clinical study published in ... Journal), clearly shows that Prebiotics reduce ... 33%. , , The controlled clinical study was conducted ... an 80% survival rate to 24 months versus a 50% ...
Cached Medicine Technology:Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM) 2Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM) 3Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM) 4New Study Shows that Prebiotics, as Used by Jackson GI Medical, Increases Lifespan by 33% 2
... battery-powered, single-use, direct current ... settings: 0.5, 1.0, and ... subdermal needle as the ... "current flow" confirmation light ...
This battery-powered, single-use pulsed stimulator delivers approximately 0.7mA at 80 pulses per second and uses a subdermal needle as the grounding (anode) electrode. A "current flow" confirmation l...
... Versatile, pocket-size peripheral ... either a full-function nerve ... block monitor, depending upon ... is attached. Includes NSL-5 ...
... The New Innervator NS232 is a basic ... twitch stimulation patterns for nerve location during ... the emergency room. ,The constant current ... known PNS that can be programmed. ,Hand-held, ...
Medicine Products: