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Research reveals new understanding of X chromosome inactivation
Date:11/27/2012

sm is regulating genes on the chromosome in a more subtle way than the binary "on/off" function posited by the prevailing model. The exact mechanism for this remains unknown. Although Calabrese believes that Xist still plays a role, its exact function and whether other factors influence X-inactivation remain questions for future research.

"We know that Xist is required to turn off the inactive X. We know that. We have no idea how" said Calabrese.

Beyond revising the understanding of how X-inactivation works, Calabrese said that deeper understanding of the function of Xist could reveal more about the role of other non-coding RNAs in cellular development. These RNAs could become useful targets for future therapies and drug development.

"We know that too much expression of the wrong non-coding RNAs can lead to cancer. Also, forced expression of other non-coding RNAs can prevent cancer. Generally, we do not know how these RNAs work," said Calabrese.


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Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert

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