Navigation Links
Research reveals new understanding of X chromosome inactivation
Date:11/27/2012

Chapel Hill, NC In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and member of the UNC Lineberger Comprehensive Cancer Center, broadens the understanding of how cells regulate silencing of the X chromosome in a process known as X-inactivation.

"This is a classic example of a basic research discovery. X-inactivation is a flagship model for understanding how non-coding RNAs orchestrate large-scale control of gene expression. In the simplest terms, we are trying to understand how cells regulate expression of their genes. Our findings are relevant across the board -- by understanding how normal cells function we can apply that knowledge to similar situations in the understanding and treatment of disease," said Calabrese.

Proper regulation of the X chromosome plays a crucial role in mammalian development. Females inherit a pair of X chromosomes from their parents, and the process of X-inactivation shuts down one of these two Xs.

"Males have XY. Females have two Xs. One of those Xs needs to get shut off. If it does not, it's not compatible with life. It's how we have evolved to equalize doses between males and females," said Calabrese.

While the manner in which the X chromosome is deactivated has been actively studied for 50 years, the exact mechanisms that regulate the process remain a mystery. Calabrese's research used high-throughput sequencing to determine the location and activity of chromosomes with far greater accuracy than previous research.

"Basically, this is using the sequencing technology as a high resolution microscope," said Calabrese.

Under a microscope, the inactive X chromosome (Xi) appears as a cloud-like structure, because it is covered with a non-coding RNA known as Xist. In the traditional model of X-inactivation, genes located i
'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers identify physiological evidence of chemo brain
2. Researchers find chemical switches for neurodegenerative diseases
3. Release all Tamiflu data as promised, argue researchers
4. Researchers link new molecular culprit to breast cancer progression
5. Elsevier launches new open access journal: Leukemia Research Reports
6. Researchers discover gender-based differences in Alzheimers disease
7. Researchers find evidence that brain compensates after traumatic injury
8. Organizations collaborate to support research on arthritis and aging
9. Solving big research questions with statistics wins 2012 Victoria Prize
10. Society of Diagnostic Medical Sonography Foundation introduces Sonography Research Institute
11. Researchers find decline in availability and use of key treatment for depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... (PRWEB) December 21, 2014 CannabisClassifieds.com celebrates marijuana’s ... The only one of its kind, the site has ... local marijuana for 14 years running. It uniquely combines ... to make cannabis readily available to the masses. Assuring ... grasping the golden ring of public approval. , ...
(Date:12/21/2014)... December 21, 2014 Concept Plus, LLC. ... firm headquartered in Fairfax, VA., today announced it has ... Fast 50 list, which ranks the fastest growing government contracting ... 2009 to 2013. , This is the first year that ... ranked # 20 with a 95.92% compound annual growth rate. ...
(Date:12/20/2014)... 21, 2014 BambooIndustry.com is ... the business has announced its bamboo flooring promotion ... best material from certified suppliers, and offers the ... worldwide. In the current promotion, all customers can ... when they say they know BambooIndustry.com from press ...
(Date:12/20/2014)... Weddingshe.com has recently announced its new ... promotion of special occasion dresses for the coming new ... special occasion dresses for global women. Now, all the ... up to 80% off. Among the new items, the ... 16 Dress) is very popular. What’s more, Weddingshe.com also ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 Dress company LunaDress ... dresses, and announced its Christmas Sale, offering big discounts on ... “Every girl has an idea to own a perfect wedding ... for your wedding dress, then come to LunaDress. Many different ... for you. Visit our website now and enjoy the current ...
Breaking Medicine News(10 mins):Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2
... campaign on health and hygiene in violence-hit Afghanistaqn from Saturday. ... aims to educate more than two million people in the ... begin in Kabul on June 24, targeting 850,000 people, before ... ,Each phase lasts 20 days, and will involve hundreds ...
... recent study has revealed that the place of birth determines the ... lower life expectancy than those born in south east England //. ... was found to be 69.3 it was found to be 77 ... the research and it has ranked the 10 best and worst ...
... District Health Boards and Primary Health Organisations, (PHOs), which faced ... both parties reaching an agreement on the extension of ... who are GP patients, aged between 45 - 64 years, ... GPs have long been at loggerheads over the conditions, ...
... Wilson, elected to undergo hysterectomy and mastectomy. due to a ... family harbors to develop breast cancer //. Oonagh’s decision came ... least two more years for the results of the genetic ... changes in service delivery and delays in getting licenses from ...
... acting chief has expressed doubts as to whether the $46 ... a mental health rehabilitation unit in the Riverina. ... for the Wagga clubhouse itself has been stalled by the ... Heath Minister they commented that the Lands Minister had approved ...
... According to a study conducted by Yale university researchers it was ... one's life resulted in an increased rate of heart attacks //. ... to 61 years. The results of the study were published in ... suffered from heart attacks and strokes in about 10 years time ...
Cached Medicine News:Health News:Life Expectancy Determined by Place of Birth 2Health News:Woman Elects For Mastectomy: Prolonged Wait For Genetic Results 2Health News:Woman Elects For Mastectomy: Prolonged Wait For Genetic Results 3
(Date:12/17/2014)... and SAN DIEGO , Dec. ... PHG ; AEX: PHIA) and Volcano Corporation (NASDAQ: ... measurement solutions for cardiovascular applications, today announced that they have ... Philips will commence a tender offer to acquire all of ... per share, or a total equity purchase price of USD ...
(Date:12/17/2014)... NASHVILLE, Tenn. , Dec. 17, 2014  Strategic ... health management software solutions, today announced a strategic agreement ... the New Jersey regional marketplace.  ... and enhance the health and wellness solutions QualCare brings ... and the surrounding region. QualCare ...
(Date:12/17/2014)... SCOTTSDALE, Ariz. , Dec. 17, 2014 /PRNewswire/ ... of state-of-the-art interactive music products, today announced that ... Ltd, a leading manufacturer and supplier of innovative ... As part of the agreement, RSL ... Facility bundled solution specifically configured for use within ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 2Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 3Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3
... LITTLE FALLS, N.J., Nov. 5 CANTEL MEDICAL CORP. ... Krakauer, President & CEO, will be presenting at the Sidoti ... formal presentation is scheduled for 9:05 AM ET on Friday, ... a Q & A session immediately following the presentation. In ...
... Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS ) today announced ... voreloxin orphan drug designation for the treatment of acute ... 2 clinical trials of voreloxin in AML: a single-agent ... elderly AML patients unlikely to benefit from standard induction ...
Cached Medicine Technology:Sunesis' Voreloxin Receives FDA Orphan Drug Designation for Acute Myeloid Leukemia 2Sunesis' Voreloxin Receives FDA Orphan Drug Designation for Acute Myeloid Leukemia 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: