Navigation Links
Research reveals molecular pathway behind invasive prostate cancers
Date:5/18/2009

CINCINNATIUniversity of Cincinnati (UC) cancer and cell biologists have identified a new molecular pathway key to the development of invasive prostate cancers.

In a preclinical study led by Maria Diaz-Meco, PhD, the UC team found that simultaneous inactivation of two particular genesknown as PTEN and Par-4caused the rapid development of invasive prostate cancer tumors in mice.

"We knew that independent mutations in either of these genes could result in benign tumors, but when those changes occur simultaneously it appears to have a synergistic effect that causes prostate cancer," explains Diaz-Meco, an associate professor of cancer and cell biology at UC and corresponding author of the paper. "This switch affects the cell's ability to both grow and survive, leading to more aggressive and invasive tumors."

"This is an important discovery becauseuntil nowthose signaling pathways were not clearly defined. Without a clear molecular target, it's impossible to develop effective drugs to treat this disease without causing harm to the patient," she adds.

Diaz-Meco and her team report their findings online ahead of print in Proceedings of National Academy of Sciences (PNAS) the week of May 18.

PTEN is a well-defined gene shown to be suppressed in prostate cancer tumors, as well as in other types of cancer. Its mutation has been shown to result in the formation of benign tumors. Par-4 gene is also mutated in prostate cancer, but this study is the first to report its relationship with PTEN mutations and aggressive prostate cancer tumor development.

The UC study was done in a laboratory mouse model over the course of two years. Data from the mouse model was correlated and compared to human prostate cancer tissue samples to determine if their findings were applicable in humans as well.

"Theoretically, this new knowledge could be used to better categorize a tumor's aggressiveness by measuring the levels of PTEN and Par-4 expressed in a tissue biopsy," adds Diaz-Meco. "That would help clinicians make tough decisions about how aggressively to treat a patient's prostate cancer and minimize unnecessary treatment."

Cancer and cell biologists are working on identifying the molecular targets involved in cancer progression to develop a better understand the mechanisms of action that lead to prostate cancer so that pharmaceutical companies and clinicians can develop better methods of diagnosing and treating the disease.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... A quote from Dr. Edward Hallowell, host ... social media that offer a rare glimpse into the mind of those people with ... York Times bestselling author, has described people with ADHD as having “Ferrari engines for ...
(Date:12/7/2016)... ... December 07, 2016 , ... The ... offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington ... needs treatment for a brain tumor. , Jason Bauer and his family are ...
(Date:12/7/2016)... ... , ... A. Kevin Spann Insurance, a New York-based firm offering insurance and ... a charity drive to raise funds that will benefit the Marine Corps League. , ... Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans ...
(Date:12/7/2016)... ... 07, 2016 , ... Delete® - Tattoo Removal and Laser Salon Offers Delightful ... Save Up To 33% Off Botox® and Juvederm® Products Now Through December 31, 2016 ... Delightful Deals on Botox® and Juvederm® just in time for the holiday ...
(Date:12/7/2016)... ... December 07, 2016 , ... Gensuite is honored to be ... Best New Product Launch category. Gensuite’s entry on their EZ Scan feature detailed ... Events & Training Group is a professional event and training provider based in ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... NORTH READING, Mass. , Dec. 7, 2016 ... Track and Trace Network for connecting the Life ... from the global marketplace, today announced that Tjoapack ... 50+ European pharmaceutical manufacturing customers comply with the ... Supply Chain Security Act (DSCSA) in 2017 and ...
(Date:12/7/2016)... According to a new market research report "Clinical Decision Support Systems Market ... Type (Therapeutic, Diagnostic), User Interactivity (Active, Passive), Application - Forecasts to 2021" ... Million by 2021 from USD 856.3 Million in 2016, at a CAGR ... ... MarketsandMarkets Logo ...
(Date:12/7/2016)... 7, 2016 Today, Stock-Callers.com presents four ... JAZZ ), Anthera Pharmaceuticals Inc. (NASDAQ: ANTH ... AveXis Inc. (NASDAQ: AVXS ). From its peak ... 37% to reach a level equal to what it saw ... approximately 14% for the year, it has still out-performed other ...
Breaking Medicine Technology: