Navigation Links
Research reveals molecular fingerprint of cocaine addiction
Date:5/27/2008

WINSTON-SALEM, N.C. The first large-scale analysis of proteins in the brains of monkeys addicted to cocaine reveals new information on how long-term cocaine use changes the amount and activity of various proteins affecting brain function.

The identified changes are more numerous and long-lasting than previously thought, which may provide a biological explanation for why cocaine addiction is so difficult to overcome, according to Scott E. Hemby, Ph.D. of Wake Forest University School of Medicine, senior author of the study.

Results from the study are reported online today (May 27) in the journal Molecular Psychiatry and detail the effect of long-term cocaine intake on the amount and activity of thousands of proteins in monkeys. Monkeys are an ideal animal for studying addiction because they share considerable behavioral, anatomical and biochemical similarities with humans. About 2.4 million Americans currently use cocaine, according to estimates.

The researchers used state-of-the-art proteomic technology, which enables the simultaneous analysis of thousands of proteins, to compare the proteome (all proteins expressed at a given time) between a group of monkeys that self-administered cocaine and a group that did not receive the drug. Leonard Howell, Ph.D., with Emory University School of Medicine, who conducted the monkey studies, was a co-researcher. The study provides a comprehensive assessment of biochemical changes occurring in the cocaine addicted brain, Hemby said.

The changes we identified are profound and affect the structure, metabolism and signaling of neurons, said lead author Nilesh Tannu, M.D. It is unlikely that these types of changes are easily reversible after drug use is discontinued, which may explain why relapse occurs.

Hemby said that the development of medications to treat addictive disorders is guided in large part by our understanding of the brain mechanisms that produce the euphoric effects of the drugs. It is equally important to understand the damage that long-term drug use causes to brain cells so medications can be developed to reverse those effects and restore normal cell function in the brain.

The changes identified in the current study point to significant and likely long-lasting damage to brain cells as a result of cocaine abuse. The duration of use and the amount of drug consumed that lead to such damage is currently not known, but is critical for understanding the long-term health consequences of cocaine abuse and determining the necessary modes of treatment, said Hemby. We hope that the information generated from the study will also serve an educational purpose as a deterrent to cocaine use.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Video/Online Games for Health: 12 Research Teams From Across U.S. To Receive Major Grants
2. SNM hosts 55th Annual Meeting of Nuclear Medicine and Molecular Imaging Research
3. AlphaRx Signs Cooperative Research and Development Agreement with US Army
4. UCLA researchers identify leukemia stem cells
5. £20M health research collaboration announced for the southwest England
6. Organic Farming Research Foundation Applauds Farm Bill Victories for Organic Farmers and Ranchers
7. Increased screening may better predict those at higher risk for heart disease, researchers report
8. Mayo Clinic researchers find common gene disorder doubles risk of lung cancer, even among nonsmokers
9. Researchers find roadmap to next-generation cancer therapies
10. Bioniche Presents Pre-Clinical Research at Two International Conferences
11. Monitoring blood flow helps improve prostate biopsies, Jefferson researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... FileHold's document management ... DocuSyst provides a cloud hosted environment for FileHold software that is pay per ... 3rd party applications using the FileHold web services API. DocuSyst also advises clients ...
(Date:2/8/2016)... , ... February 08, 2016 , ... TopConsumerReviews.com recently awarded ... Mole removal products. , Moles are derived from a cluster of melanin when exposed ... the wrong places and create a lifetime of embarrassment. Historically, mole removal ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... only four states in the U.S. require dental technicians to be certified or ... the dental industry, NADL created the “What’s In Your Mouth?” campaign to inform ...
(Date:2/7/2016)... ... February 07, 2016 , ... Dr. Todd Hobgood ... his medical and surgical expertise. Technically known as deoxycholic acid or previously as ... a non-surgical alternative for reduction of fat below the chin (aka the “double ...
(Date:2/6/2016)... ... February 06, 2016 , ... Shark Finds ... the launch of a new DRTV campaign with Belly Bands. , Having a dog ... from sprays to puppy pads and find nothing works, get Belly Bands, the ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Switzerland and PALO ALTO, Calif. , Feb. ... and chemical manufacturing, and Kodiak Sciences Inc., a biopharmaceutical ... of retinal disease, announced today agreements for the clinical ... will manufacture material at multiple sites, including Slough (UK), ... --> --> Retinal diseases, such as ...
(Date:2/8/2016)... /PRNewswire/--  Cell Applications, Inc. and Cyfuse Biomedical ... now available in North America ... approach called the "Kenzan Method." Utilizing Cyfuse Biomedical,s ... robotic system that fabricates 3D tissue from cells, ... model that makes scaffold-free tissue available immediately to ...
(Date:2/8/2016)... 2016  Avista Pharma Solutions ("Avista Pharma") announced today ... Financial Officer (CFO). Mr. Setzer is a finance and ... various roles within growing technology and life science companies. ... Executive Director of Finance at INC Research, a publicly ... . Previously, Mr. Setzer served as CFO of ...
Breaking Medicine Technology: