Navigation Links
Research reveals how antibodies neutralize mosquito-borne virus
Date:4/2/2013

WEST LAFAYETTE, Ind. - Researchers have learned the precise structure of the mosquito-transmitted chikungunya virus pathogen while it is bound to antibodies, showing how the infection is likely neutralized.

The findings could help researchers develop effective vaccines against the infection, which causes symptoms similar to dengue fever, followed by a prolonged disease that affects the joints and causes severe arthritis. In recent outbreaks, some cases progressed to fatal encephalitis.

The researchers studied "virus-like particles," or non-infectious forms of the virus. They also obtained near atomic-scale resolution of the virus attached to four separate antibodies.

"We knew these antibodies neutralize the real virus, so we wanted to know how they do it," said Michael Rossmann, Purdue University's Hanley Distinguished Professor of Biological Sciences.

Findings are detailed in a research paper appearing Tuesday (April 2) in the journal eLife.

The scientists used a technique called cryoelectron microscopy to uncover critical structural details about the virus-like particles bound to the antibodies. The particles are made of 180 "heterodimers," molecules made of two proteins: envelope protein 1, or E1, and envelope protein 2, or E2.

The findings show the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers making up the virus's outer shell. The analyses showed that the antibodies stabilize the viral surface, hindering fusion to the host cell and likely neutralizing infection.

Chikungunya is an alphavirus, a family of viruses that includes eastern equine encephalitis.

"This is the first time the structure of an alphavirus has been examined in this detail," Rossmann said.

The research is aimed at learning precisely how viruses infect humans and other hosts, knowledge that may lead to better vaccines and antiviral drugs, Rossmann said.

Chikungunya in 2005 caused an epidemic on Runion Island. A mutation in the E1 protein has allowed the virus to replicate more efficiently, which is considered the primary reason for its recent extensive spread, infecting millions of people in Africa and Asia.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert

Related medicine news :

1. LSUHSC research discoveries shed light on common STI
2. Sanford-Burnham collaborates with 5 Florida-based research organizations
3. PhD Box invites contributions for Research Topics Contest
4. Juice Production in the US Industry Market Research Report from IBISWorld has Been Updated
5. Medical Supplies Wholesaling in the US Industry Market Research Report from IBISWorld has Been Updated
6. Researchers are first to use common virus to fortify adult stem cells
7. Princess Margaret breast cancer research finds new drug target companion prognostic test for hormone therapy resistance
8. Congresswoman Michelle Bachmann Supports Barak Obama's Call to Prioritize Research to "Unlock the Answers to Alzheimer's"
9. Researchers discover new clues about how amyotrophic lateral sclerosis develops
10. Global Biopsy Devices Market - New Market Research Report Published by Transparency Market Research
11. Induction Hobs Market - New Market Research Report Published by Transparency Market Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... To better understand the ... research award to examine gender differences in lung cancer. Today, the Lung Association announced ... Lung Cancer in Women Award, funded by the American Lung Association’s LUNG FORCE initiative, ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... Roberta Jordan. , Roberta Jordan is a Certified Nurse Midwife who was ... State University and then went on to complete her masters degree from the ...
(Date:5/24/2016)... ... ... Jericho Project has named LaToya Williams-Belfort to the position of Chief Development and Communications ... the nationally-acclaimed nonprofit, working closely with CEO Tori Lyon and the Board of Directors ... , “LaToya Williams-Belfort is joining Jericho at an exciting time of growth and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Altura ... today announced a strategic partnership with Five9 (Nasdaq: FIVN), a leading provider ... of Avaya’s largest Platinum Business Partners, is a leading provider of communication-enabled ...
(Date:5/24/2016)... ... 24, 2016 , ... Local engineering firm, Timmons Group, announced ... located in Woodbridge, VA. The project includes a brand new operating room ... The new 2 story building houses the Central Sterile department, Sterile prep area ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... 2016 According to market ... Growth and Demand Forecast to 2022 - Industry ... Application (Drug Discovery and Development, Proteomics, Clinical Testing, ... Science and Biotechnology, Academic and Research Institute, Hospitals ... global mass spectrometry market was valued ...
(Date:5/23/2016)... , May 23, 2016 Non-invasive ... detection of multiple diseases; ,Technology to be presented at ... Yissum Research Development Company of the Hebrew University ... a research agreement with Aurum Ventures MKI, the technology investment ... of a new diagnostic approach for early detection of ...
(Date:5/23/2016)... FRANCISCO , May 23, 2016 ... to reach USD 5.0 billion by 2022, according to ... increasing generation of medical waste coupled with the lack ... industry is expected to drive the demand for reprocessed ... these devices as compared to that of the original ...
Breaking Medicine Technology: