Navigation Links
Research reveals further progress toward AIDS vaccine
Date:12/14/2009

(PHILADELPHIA) Researchers from Thomas Jefferson University are one step closer to developing a vaccine against the AIDS disease.

Led by Matthias J. Schnell, Ph.D., director of the Jefferson Vaccine Center, the researchers found that a rabies virusbased vaccine administered to monkeys protected against the simian equivalent of the HIV virus (SIV). The data were published in the journal Vaccine.

The researchers previously showed that a rabies-based vaccine expressing HIV and SIV antigens protective against a chimeric HIV/SIV virus in monkeys. In this study, they used highly attenuated rabies virus vaccine vectors to protect against challenge with the highly pathogenic SIVmac251. This type of SIV virus causes a more similar disease in monkeys compared to human infection with HIV-1. In addition, it is difficult to protect monkeys against AIDS-like disease after challenge with SIVmac251.

Two vaccine strategies were used: immunization with a recombinant rabies virus expressing SIVmac239GagPol, or a combination of that and a rabies virus expressing SIVmac239Env. Both strategies induced neutralizing antibody production, CD8+ T cell responses, and increased protection. Although the combination with Env helped immediately following the infection, the long-term benefits were minimal. However, it was surprising that the rabies-based vaccine was able to induce such potent anti-SIV humoral responses.

"Although we can't yet block the infection, we showed that we can protect against disease," said Dr. Schnell. "We also saw significant antibody activity against the virus, which is promising. In addition, this is a very simple approach that only took two immunizations."


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo Clinic researchers say breast cancer survival improves Herceptin used with chemotherapy
2. Autism Research at the Childrens Hospital of Philadelphia Is Among Time Magazines Top 10 Medical Breakthroughs
3. New research identifies modifiable risk factors for heart disease
4. University of Maryland chemist receives Astellas Award for blindness prevention research
5. University of Alberta researchers develop drug interface to save lives
6. Late-breaking brain and behavior research presented at ACNP annual meeting this week
7. Rachel Alexandra, Kendall-Jackson Donate $20,000 to V Foundation for Cancer Research
8. Cohen Independent Research Group Issues a Buy Rating With a Target Price of $2.48 for VHGI; 8K filed regarding $50,000,000.00 Treasure Gulch Gold Reserves
9. Researchers identify barriers to HPV vaccination uptake in low-income populations
10. Scripps Research scientists reveal key structure from ebola virus
11. Researchers Use New Techniques to Assess PTSD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... (PRWEB) October 02, 2014 USARAD ... teleradiology and telemedicine solutions provider including its SecondOpinions.com® ... Backhaus have joined its Executive Team as President ... , Brent Backhaus, USARAD’s new President and COO, ... years of progressively responsible experience in commercial-, medical- ...
(Date:10/2/2014)... Social-Engineer, Inc. the leader in security testing and ... a complimentary webinar on Friday, October 31, at 1:00PM ... of the annual Social-Engineer Capture the Flag (SECTF) competition ... explore how to maximize security and employee performance to ... the webinar go to: Free Webinar Registration . ...
(Date:10/2/2014)... is a distinguished bamboo product manufacturer and retailer. Plenty ... global customers in the past few years. Now, the ... All its online workers are professional and patient; they ... company has recently added a new assortment of ... marketing specialist has announced that all these brand new ...
(Date:10/2/2014)... may interact with stress to trigger heart disease in some ... in about 13 percent of people, but only in those ... their heart disease risk through simple measures such as ... researchers said. The study authors analyzed genetic data from ... in the EBF1 gene and higher levels of central obesity, ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 (HealthDay News) -- ... may face an increased risk of dying in the next several ... older Americans, researchers found those who were unable to detect scents ... as likely to die in the next five years, versus those ... the inability to distinguish odors -- was a bigger predictor of ...
Breaking Medicine News(10 mins):Health News:Teleradiology and Telemedicine Pioneers Brent Backhaus and Lorna Backhaus Join USARAD Holdings, INC. & SecondOpinions.com® 2Health News:Teleradiology and Telemedicine Pioneers Brent Backhaus and Lorna Backhaus Join USARAD Holdings, INC. & SecondOpinions.com® 3Health News:Social-Engineer, Inc. Announces DEF CON 22 Capture the Flag Results in a Complimentary Webinar 2Health News:Social-Engineer, Inc. Announces DEF CON 22 Capture the Flag Results in a Complimentary Webinar 3Health News:High Quality Bamboo Panels Online At BamboofloorChina.com 2Health News:Genes May Make Some More Prone to Heart Disease When Under Stress 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3
... - Promotes Commercial Products at Major Cardiology Conferences - - ... - Achieves Efficiencies and Conserves Cash by Consolidating R&D ... ... Neovasc Inc. (TSXV: NVC), a,new specialty vascular device company, today reported on ...
... A very difficult-to-treat child leukemia may benefit from the ... launches the cancer but could potentially be reversed ... The study, led by researchers at Children,s Hospital Boston ... in the November 4 issue of Cancer Cell ...
... Rhode Island Hospital researchers have identified genetic proteins, also ... the microscopic level that can signal a precancerous condition ... who are likely to progress to esophageal cancer. This ... journal Clinical Cancer Research . , Barrett,s esophagus ...
... DUBLIN, Calif., Nov 3 SuperGen, Inc. (Nasdaq:,SUPG), ... development,of novel cancer therapies, today announced that James ... scheduled to present at the,Rodman & Renshaw 10th ... the New York Palace Hotel., SuperGen,s presentation ...
... Global Awards Ceremony Featuring Performances by Grammy Award ... Country Music Star Kenny Rogers, OAK BROOK, ... hosted its 24th Annual Awards of Excellence,celebration on ... who have made outstanding contributions to improve the ...
... CONCORD, Mass., Nov. 3 The Melanoma,Foundation of ... to its fall symposium: "Updates in Melanoma Treatment",presented ... Melanoma Program at Dana,Farber Cancer Institute. A portion ... "Immunotherapy: A Panel Presentation," which includes a panel ...
Cached Medicine News:Health News:Neovasc Reports Development Progress, Streamlined Operations and Issuance of Options 2Health News:Neovasc Reports Development Progress, Streamlined Operations and Issuance of Options 3Health News:Neovasc Reports Development Progress, Streamlined Operations and Issuance of Options 4Health News:Neovasc Reports Development Progress, Streamlined Operations and Issuance of Options 5Health News:Tackling a hard-to-treat childhood cancer by targeting epigenetic changes 2Health News:New research finds markers for esophageal cancer before it develops 2Health News:Ronald McDonald House Charities(R) Awards of Excellence Honors Peter and Virginia Ueberroth, Dr. Catherine D. Deangelis and Lionel Whitehead 2Health News:Ronald McDonald House Charities(R) Awards of Excellence Honors Peter and Virginia Ueberroth, Dr. Catherine D. Deangelis and Lionel Whitehead 3
(Date:10/2/2014)... 2, 2014  InfinityQS International, Inc., the global ... announces key client speakers for Infusion Chicago, its ... The event will be held Oct. 9-10, 2014, ... include projects from Coloplast, The Kellogg Company, Biomet, ... King. The two-day event will also include best ...
(Date:10/2/2014)...  AxelaCare Health Solutions, www.axelacare.com , a leading ... it has acquired Advanced Care, a New ... of the transaction were not disclosed. The ... to 18 nationwide and expands AxelaCare,s national home IV ... - New Jersey metro area.  AxelaCare ...
(Date:10/2/2014)...   Intarcia Therapeutics, Inc. today announced successful ... clinical trials for ITCA 650 (exenatide, delivered continuously once ... The first trial, FREEDOM-1, was a placebo-controlled, double-blind phase ... of ITCA 650 in patients with type 2 diabetes ... significantly superior to placebo for both 40 mcg and ...
Breaking Medicine Technology:InfinityQS Infusion Chicago to Spotlight Manufacturers' Key Successes in Achieving Enterprise Quality 2InfinityQS Infusion Chicago to Spotlight Manufacturers' Key Successes in Achieving Enterprise Quality 3AxelaCare Health Solutions Acquires Advanced Care of New York 2AxelaCare Health Solutions Acquires Advanced Care of New York 3Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 2Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 3Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 4Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 5
... Health Inc, Morrisville, NC has introduced IronUp, a Liquid ... dietary iron for infants and children who do not ... (Photo: http://photos.prnewswire.com/prnh/20110810/CL49882 ) ... supplement from a bioavailable source of iron that is ...
... 9, 2011 Q2 2011 Highlights (compared to ... 9% to $109.6 million Product revenue rose 17% to $102.6 ... 2% to 37,300 Masimo rainbow revenue rose 26% to $9.1 ... prior period, which included $0.01 in one-time expenses.  Excluding the prior ...
Cached Medicine Technology:YASOO Health Introduces IronUp™ 2Masimo Reports Second Quarter 2011 Financial Results 2Masimo Reports Second Quarter 2011 Financial Results 3Masimo Reports Second Quarter 2011 Financial Results 4Masimo Reports Second Quarter 2011 Financial Results 5Masimo Reports Second Quarter 2011 Financial Results 6Masimo Reports Second Quarter 2011 Financial Results 7Masimo Reports Second Quarter 2011 Financial Results 8
IVUS console...
FemoStop system is a femoral compression system for hemostasis management. It provides a comfortable and efficient "hands off method of compressing the femoral artery and vein after diagnostic and i...
VasoSeal ES is a extravascular arterial sealing. It utilizes a unique temporary arterial locator system which provides an easier and surer method of locating the femoral artery....
... was the first device ... after diagnostic and interventional ... It is a collagen-based ... for immediate sheath removal ...
Medicine Products: