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Research provides new findings on drug delivery with nanoparticles
Date:3/1/2011

h is supported by the Danish Agency for Science, Technology and Innovation. This work was done as part of ongoing research at the Centre.

Professor Moghimi's main focus is nanotoxicology and the possible consequences of drug delivery with nanoparticles.

"Our newest research indicates that we should be very cautious when designing the surface of the nanoparticles. Remarkably, changing the conformation of the coating polymers on nanoparticle surface from a 'mushroom-type' to a 'brush-type' appearance can switch complement activation from one pathway to another," explains Professor Moghimi.

The research demonstrates difficulty in design and surface engineering of polymeric nanoparticles such that it is hydrophilic enough to be compatible with biological fluids and yet prevent complement activation.

This is also very important from clinical perspectives since complement activation may induce adverse reactions in some patients.

The importance of this work was also highlighted in an all exclusive "News and Views" by the prestigious Nature Nanotechnology.


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Contact: Moein Moghimi
momo@farma.ku.dk
455-121-7975
University of Copenhagen
Source:Eurekalert

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