Navigation Links
Research provides insight into quality of stored blood used for transfusions
Date:5/20/2011

New research provides evidence for significant differences between new and old red blood cells used for transfusions and could provide a cheap, rapid and effective way to monitor the quality of blood supplies.

Even with preservatives, blood stored in banks continues to age, resulting in biomaterials leaking from the red blood cells and subsequent changes to cell properties and function. There have been concerns raised worldwide about using older stored blood because of questions about various changes believed to affect the quality of the red blood cells. Currently, blood stored in a special medium can be used for clinical transfusion for up to 42 days, but monitoring of the blood varies.

Dr Jay Mehrishi, PhD, FRCPath (a Fellow of the Royal College of Pathologists), formerly of the Department of Radiotherapeutics and Medicine (now called the Department of Haematology) at the University of Cambridge and one of the lead authors of the study, said: "Recent trials on cardiac surgery patients involving over 40,000 patients showed that transfused blood which was older than 14 days produced serious side effects.

"The side effects of transfusing old blood are thought to result in acute lung injury and possible adverse effects of the immune system. In severe trauma patients, transfusion of blood stored for more than 28 days doubled the incidence of deep vein thrombosis and increased death secondary to multiple organ failure. Our research will hopefully highlight the significant differences between old and new blood used in transfusions as well as the possibility of using our technique to quickly and cheaply monitor blood supply quality."

The electrical properties of red blood cells have previously been used to distinguish between foetal and adult haemoglobin as well as the mutated form of haemoglobin found in sickle cells from normal haemoglobin. Now, using the unique electrical properties of red blood cells, Dr Mehrishi, working with Professor Yao-Xiong Huang from the Ji Nan University in China, used fluorescence from the positively charged quantum dots, which had been bound to electrical charges on the negatively charged cells to discriminate between old cells (which had diminished in quality) and young cells.

On young red blood cells (left of the figure) the fluorescence was intense bright, indicating that the surface architecture was intact. Whereas on the older red blood cells (right of the figure), the fluorescence was almost zero and the cells shown significantly darker, indicating that there had been a substantial loss of the electrical charges, indicating the cell membrane integrity had been compromised. It is recognised that such damaged cells are not useful for transfusions because the body eliminates them from circulation quite quickly.

Dr Mehrishi continued: "This study is the culmination of decades of research into blood cells, and a collaboration with the skilful Professor Huang - persevering with his expertise and team - and I am thrilled that for the first time visual imaging has provided evidence for the quality of the red blood cells.

"We need simple, routine quality control monitoring of blood in storage to avoid the serious adverse effects caused by biomaterials released from damaged cells accumulating."

In addition to its use as a monitoring technique for the quality of blood stored in blood banks, Dr Mehrishi believes that it could also be used to ensure a high quality of 'cleaned up' blood (older blood which has had the leaked biomaterials removed), which is of immense practical clinical importance worldwide.

Dr Mehrishi said: "These results are not only of theoretical interest but are also of immense practical clinical value, with vast commercial potential for new, rapid automated monitoring tests in clinics and in blood banks worldwide.

"Our novel approach is also likely to be of practical value in clinics before, during and after therapy, for such problems as circulatory disorders, abnormal red cells, macrophages - e.g.in Gaucher disease -, respiratory physiology, hypoxia, high-altitude mountaineers, residents at high altitudes, etc."

The findings have been published in the Journal of Cellular and Molecular Medicine.


'/>"/>

Contact: Genevieve Maul
Genevieve.maul@admin.cam.ac.uk
44-122-376-5542
University of Cambridge
Source:Eurekalert

Related medicine news :

1. Caltech research helps paraplegic man stand and move legs voluntarily
2. Researchers connect electrical brain disturbances to worse outcomes following neurotrauma
3. Eat a protein-rich breakfast to reduce food cravings, prevent overeating later, researcher finds
4. Pitt researchers build a better mouse model to study depression
5. Researchers discover that lymphocyte count indicates prognosis of patients with renal cell carcinoma
6. Researchers home in on genetic signature of esophageal cancer
7. Legendary Hollywood directors and renowned researchers awarded 2011 Dan David Prizes
8. Columbia researchers work to prevent blindness from age-related macular degeneration
9. Hebrew University researchers show octopuses make some pretty good moves
10. Penn researchers identify the roots of memory impairment resulting from sleep deprivation
11. Cole Foundation injects $700,000 into childhood cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... Jamaica (PRWEB) , ... April 30, 2016 , ... ... and Duane Boise, President and CEO of EMED, today signed a multifaceted agreement ... , EMED and the Northern Caribbean University Department of Natural and Applied Sciences, ...
(Date:4/30/2016)... ... 2016 , ... “Aging well is a challenge for all of us, but there are things we can do ... . “Research is showing more and more that there are simple, yet important steps that ... we age.” Top priorities Dr. Kohli’s recommends for her patients include;, , ...
(Date:4/29/2016)... ... 2016 , ... World Patent Marketing , a vertically ... automotive invention that improves the storage features of a pick up truck. , ... Cooper, CEO and Creative Director of World Patent Marketing. "Over the next five ...
(Date:4/29/2016)... ... ... In an article published April 16th on the New York ... injections, which she underwent in order to feel more at home at this year’s ... article explains that Ms. Mirmelli’s situation is not unique; many plastic surgeons say they’ve ...
(Date:4/29/2016)... ... April 29, 2016 , ... Memorial Healthcare System ... Medical Education (ACGME) that it has received accreditation for its residency program on ... residency programs that Memorial is currently pursuing, including Pediatrics and Internal Medicine. This ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016 Automation is one of ... to the growing demands for productivity in speed, accuracy, ... systems are already adept of a wide range of ... manual labor. Instrumentation continues to evolve, and is poised ... a few years ago. Originally used mostly by the ...
(Date:4/28/2016)... YORK , April 28, 2016  While ... notably complement the company,s valve repair and stent ... move also places Abbott more firmly into patient ... of the fastest growing device areas, with double-digit ... its recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... 2016  Marking its one year anniversary since ... cancer risk test, Color Genomics announced ... highly impact the most common hereditary cancers affecting ... Test analyzes hereditary cancer risks for breast, colorectal, ... The Color Test is physician ordered and includes ...
Breaking Medicine Technology: