Navigation Links
Research program focuses on genetic mutations and cancer risk
Date:5/5/2008

PITTSBURGH, May 5 The University of Pittsburgh Cancer Institute (UPCI) today announced the establishment of the Frieda G. and Saul F. Shapira BRCA Cancer Research Program. BRCA 1 and 2 are two genes that, when mutated, dramatically increase the risk of breast, prostate, ovarian and pancreatic cancers.

I am excited about the addition of this research program to UPCI, said Ronald Herberman, M.D., director of UPCI and the University of Pittsburgh Medical Center (UPMC) Cancer Centers. The more we learn about these mutations, the better chance we have to target high-risk patients and to find innovative ways to reduce their cancer risk.

Women who possess either mutation have a 50 to 80 percent lifetime risk of developing breast cancer, and the disease progresses more quickly than in individuals without the mutations. Experts estimate that as many as one out of every 345 people in the U.S. carries a BRCA mutation, but for individuals of Ashkenazi (Eastern European) Jewish descent, the number is approximately one in 40.

These mutations have been linked primarily with an increased risk of breast cancer in women, but they also increase the risk for other cancers. Both men and women can carry the genetic mutations, which means they can be passed to children from either parent.

The David S. and Karen A. Shapira Foundation committed an initial $1 million for the program, structuring the gift as a matching grant to raise an additional $1.5 million from individuals and foundations. UPMC is matching these gifts on a dollar-for-dollar basis, for an overall goal of $5 million.

Currently, the burden of cancer costs each American approximately $936 a year, said Dr. Herberman. The National Cancer Institutes budget supporting research amounts to only $21 per American annually. To fund promising cancer research, researchers need other means of support. A gift like the one we have received from the Shapira Foundation, complemented by funds from the community and UPMC, will go a long way to supporting this important program.


'/>"/>

Contact: Courtney McCrimmon
McCrimmonCP@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
Source:Eurekalert

Related medicine news :

1. ESA contributes to ocean carbon cycle research
2. CNS Response, Inc: rEEG(R) Research to be Presented at 38th National Council Conference
3. Stanford researchers synthesize compound to flush HIV out of hiding
4. World first: researchers develop completely automated anesthesia system
5. St. Davids HealthCare and Texas Cardiac Arrhythmia Announce International Center For Training, Research and Treatment of Heart Rhythm Disorders
6. Rutgers research partner Stemcyte, Inc., expands to New Jersey
7. Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting
8. New research on hearing health underscores the importance of better hearing and speech month
9. Family history places women at risk of pelvic organ prolapse, SLU research finds
10. Researchers Develop Quick Way to Create Human Antibodies
11. New Research From Packard Childrens Hospital Experts Presented at 2008 Pediatric Academic Societies Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... San Fernando Valley, CA (PRWEB) , ... December 07, 2016 , ... ... Sculptra can be used in several ways to restore a more youthful appearance to ... doctors , now offer Sculptra, along with a variety of other treatments, to rejuvenate ...
(Date:12/7/2016)... ... 2016 , ... ODU, a worldwide leader in designing ... advanced highly customizable contact technology solutions. , ODU Single Contact Technology portfolio includes: ... for a wide range of applications that require customization from industries like emobility, ...
(Date:12/7/2016)... ... 2016 , ... AlignLife clinics nationwide are giving back to their communities by ... receive bountiful gifts wrapped tightly under a Christmas Tree. AlignLife hopes to spread ... world. , In exchange for generous donations, customers will receive a gift in return. ...
(Date:12/7/2016)... ... December 07, 2016 , ... Facial plastic surgeon, Dr. John ... by donating a portion of proceeds to two local organizations: North Chicago Animal Control ... & Friends is a team of authorized and trained volunteers who support rescued ...
(Date:12/7/2016)... ... 2016 , ... "ProBrand Flip allows FCPX editors to create unique logo reveals ... of Pixel Film Studios. , ProBrand Flip includes 30 flip book reveal animations. Easily ... from a variety of flip book animations. In Addition, users can modify each preset ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- Lannett Company, Inc. (NYSE: LCI ) today announced that ... for Success Healthcare Conference on December 14, 2016 at 9:20 a.m. ... City . In addition, the company will host ... th Annual Boston Healthcare Conference taking place on December 13, ... ...
(Date:12/6/2016)... Mass. , Dec. 6, 2016  Alopexx Oncology, ... DI-Leu16-IL2, a recombinant antibody fusion protein (immunocytokine) composed of ... recognizes the same target on B cells as Rituxan ... cytokine components but is also involved in tumor targeting, ... anti-cancer vaccine effect. The results of the study (abstract ...
(Date:12/6/2016)... , Dec. 6, 2016 Diabetes & Obesity ... diabetes and obesity disease cluster is currently dominated by ... type 2 diabetes mellitus (T2DM), and the majority of ... of products, is attributable to these indications. While products ... market presence, there are a large number of these ...
Breaking Medicine Technology: