Navigation Links
Research practices must be changed to minimize fraud, deception
Date:3/22/2011

Ann Arbor, Mich. In 1998, a study linking the measles, mumps and rubella (MMR) vaccine to autism in children appeared in a respected medical journal. For a decade, the study grabbed headlines worldwide. Worried parents rejected the life-saving vaccine for their children and those with autistic children agonized that they allowed an injection that caused the condition.

But the vaccine-autism research was a fraud. The paper was retracted 12 years later, denounced as an elaborate deception.

"The fraud in that MMR study epitomizes how fabricated research can lead to a domino effect of tragic consequences," says Vineet Chopra, M.D., F.A.C.P., F.H.M., assistant professor of Internal Medicine at U-M. "Patients fear potentially lifesaving interventions, clinicians alter practice and scientists and governments waste precious resources to evaluate researchers' claims."

Chopra expresses these concerns in a commentary published in the Journal of the American Medical Association March 23 with Matthew Davis, M.D., M.A.P.P., associate professor of pediatrics and communicable diseases, internal medicine and public policy at the University of Michigan Medical School and Gerald R. Ford School of Public Policy. They call for changes throughout the research process to adjust expectations for researchers that conduct studies, the journals that publish results and the public that responds to the findings.

Chopra and Davis emphasize the critical importance of equipoisea state of genuine uncertainty on the part of the researcher as to what a study will reveal.

"In an era of increasing competition for funding and publication, researchers face mounting pressure to report the results they wish to see," says Davis. "Of course, it's natural for the public to want unequivocal advances in understanding and the latest accomplishments in medical research. But research doesn't always yield those results.

"The key is for funders, journals, the media and the public to value equipoise in the research process, rather than only the results."

In their JAMA commentary, Chopra and Davis recommend steps to reach research equipoise:

  1. Mandate the public release of all available data in connection with a study, as opposed to specific data associated with outcomes.
  2. Reduce publication bias, in which medical journals accept and publish chiefly those studies with statistically significant results. This jeopardizes consideration and dissemination of research pertaining to findings on both sides of an issue, and influences investigators before research begins.
  3. Shift the focus of public and private sponsors of research from outcome to process, affirming that study veracity is more valuable than results.
  4. Train researchers to recognize, appreciate and root out biases in their work.

"Researchers may lie about their research for personal or political gain. They make front page news when they get caught, but they represent a small part of the overall picture. A broader problem occurs when a researcher conducts a study with an answer to their question already in mind. Their certainty, rather than genuine uncertainty, influences their investigation and reporting, leading to results that may not be accurate," says Chopra.


'/>"/>

Contact: Mary F. Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Gift will allow Mayo researchers to explore cause of dementia in the elderly
2. Philanthropic pledge triples funds for TGen ovarian cancer research
3. Stanford researchers discover molecular determinant of cell identity
4. Terminolgy matters in parents willingness to enroll their children in research
5. CDC, Cook County and Rush collaborate to research and prevent hospital infections
6. Researchers discover possible biomarker and therapeutic target for melanoma
7. Innovative technique gives vision researchers insight into how people recognize faces
8. Important funding for nanomedicine research to improve diagnosis and treatment
9. Treatment for alcohol dependence might work best in certain populations, research suggests
10. HIV research included in journal
11. Fragile X researcher honored by March of Dimes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
Breaking Medicine Technology: