Navigation Links
Research practices must be changed to minimize fraud, deception
Date:3/22/2011

Ann Arbor, Mich. In 1998, a study linking the measles, mumps and rubella (MMR) vaccine to autism in children appeared in a respected medical journal. For a decade, the study grabbed headlines worldwide. Worried parents rejected the life-saving vaccine for their children and those with autistic children agonized that they allowed an injection that caused the condition.

But the vaccine-autism research was a fraud. The paper was retracted 12 years later, denounced as an elaborate deception.

"The fraud in that MMR study epitomizes how fabricated research can lead to a domino effect of tragic consequences," says Vineet Chopra, M.D., F.A.C.P., F.H.M., assistant professor of Internal Medicine at U-M. "Patients fear potentially lifesaving interventions, clinicians alter practice and scientists and governments waste precious resources to evaluate researchers' claims."

Chopra expresses these concerns in a commentary published in the Journal of the American Medical Association March 23 with Matthew Davis, M.D., M.A.P.P., associate professor of pediatrics and communicable diseases, internal medicine and public policy at the University of Michigan Medical School and Gerald R. Ford School of Public Policy. They call for changes throughout the research process to adjust expectations for researchers that conduct studies, the journals that publish results and the public that responds to the findings.

Chopra and Davis emphasize the critical importance of equipoisea state of genuine uncertainty on the part of the researcher as to what a study will reveal.

"In an era of increasing competition for funding and publication, researchers face mounting pressure to report the results they wish to see," says Davis. "Of course, it's natural for the public to want unequivocal advances in understanding and the latest accomplishments in medical research. But research doesn't always yield those results.

"The key is for funders, journals, the media and the public to value equipoise in the research process, rather than only the results."

In their JAMA commentary, Chopra and Davis recommend steps to reach research equipoise:

  1. Mandate the public release of all available data in connection with a study, as opposed to specific data associated with outcomes.
  2. Reduce publication bias, in which medical journals accept and publish chiefly those studies with statistically significant results. This jeopardizes consideration and dissemination of research pertaining to findings on both sides of an issue, and influences investigators before research begins.
  3. Shift the focus of public and private sponsors of research from outcome to process, affirming that study veracity is more valuable than results.
  4. Train researchers to recognize, appreciate and root out biases in their work.

"Researchers may lie about their research for personal or political gain. They make front page news when they get caught, but they represent a small part of the overall picture. A broader problem occurs when a researcher conducts a study with an answer to their question already in mind. Their certainty, rather than genuine uncertainty, influences their investigation and reporting, leading to results that may not be accurate," says Chopra.


'/>"/>

Contact: Mary F. Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Gift will allow Mayo researchers to explore cause of dementia in the elderly
2. Philanthropic pledge triples funds for TGen ovarian cancer research
3. Stanford researchers discover molecular determinant of cell identity
4. Terminolgy matters in parents willingness to enroll their children in research
5. CDC, Cook County and Rush collaborate to research and prevent hospital infections
6. Researchers discover possible biomarker and therapeutic target for melanoma
7. Innovative technique gives vision researchers insight into how people recognize faces
8. Important funding for nanomedicine research to improve diagnosis and treatment
9. Treatment for alcohol dependence might work best in certain populations, research suggests
10. HIV research included in journal
11. Fragile X researcher honored by March of Dimes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... acoustic and privacy panel system. , The Tranquility privacy panel system was ... collaborative office environment. Tranquility panels help reduce noise and provide the visual privacy ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Sam & Associates ... to commercial and residential clients in the California Bay Area, is launching a charity ... in the region. , Heart disease is the primary killer of adult men and ...
(Date:1/19/2017)... ... 19, 2017 , ... For the third year running, Noto ... the surrounding area, is inaugurating a charity event to help raise funds ... Lou Gehrig's disease or motor neurone disease, is a deadly neurological disorder that ...
(Date:1/19/2017)... ... January 19, 2017 , ... Creative messages ... Real Impact contest from Impact Teen Drivers and California Casualty. Entries from students ... , Educational grants totaling $15,000 will be awarded for the best peer-to-peer messages ...
(Date:1/19/2017)... San Diego, CA (PRWEB) , ... January 19, 2017 , ... ... for their 2017 collaboration with the American Heart Association; “Howe” Healthy is Your ... how to stay healthy and active. Each year, Bill Howe Plumbing, Heating & Air ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... England , January 19, 2017 ... and Otsuka in the Milner Therapeutics Consortium   ... scientists in Cambridge   ... (NYSE: PFE ) as a partner to ... the Consortium, which enables the efficient transfer of materials ...
(Date:1/19/2017)... 2017  ViewRay, Inc. (Nasdaq: VRAY ... clinical MRI-guided radiation therapy system, announced today that it ... million through a private placement of its common ... financing and was joined by certain of ViewRay,s ... Venture Partners, and an additional new institutional investor, ...
(Date:1/19/2017)... , Jan. 18, 2017 The Academy ... and Drug Administration (FDA) for its release today ... population health decision makers can proactively share clinical ... as well as emerging therapies awaiting FDA approval. ... consensus recommendations that AMCP developed during two multi-stakeholder ...
Breaking Medicine Technology: