Navigation Links
Research points to a new way to protect kidneys threatened by insufficient blood or toxins
Date:5/18/2009

AUGUSTA, Ga. - Better treatments for acute renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get enough blood or are exposed to toxins, researchers at the Medical College of Georgia report in the may issue of the Journal of Clinical Investigation.

Stress on kidney cells caused by vascular obstruction, trauma, chemotherapy, even antibiotics cause mitochondria - the cell's powerhouse - to "go to pieces," says Dr. Zheng Dong, cell biologist in the MCG Schools of Medicine and Graduate Studies and at the Charlie Norwood Veterans Affairs Medical Center.

Fragmentation sets in motion a chain of events that prompts kidney cells to commit suicide and leads to acute renal failure.

"When mitochondrial fragmentation is blocked, it can save the cells and the kidneys," he says.

Dr. Dong and his colleagues used an inhibitor of the natural fission process mitochondria use to multiply. They will further examine the cell death pathway - and try blocking it - in human kidney biopsies and eventually in whole organs. One of his goals is to develop safer, more efficacious drugs that can be given to patients in acute renal failure.

Acute renal failure, a disease with high mortality rates, is on the rise because of increasing cases of cardiovascular disease, diabetes and other health-related problems that prevent the kidneys from getting sufficient blood.

In addition to acute renal failure, Dr. Dong believes fragmentation inhibitors can improve preservation of kidneys extracted from a donor for transplant.

What these drugs may block is a rapid death march that only begins with the breakup. Next, two proteins, Bak and Bax, typically found at divergent places in the cell, work together to make pores in the mitochondrial outer membrane. Cytochrome c, a protein that normally helps mitchondrion breathe and produce fuel, escapes through the pores. Out of place, it becomes a deadly accomplice that activates suicide pathways. Interestingly, in a study published in 2007 in the Proceedings of National Academy of Sciences (USA), Dr. Dong's laboratory showed that mitochondrial fragmentation involves Bak but not Bax.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research points to a new way to protect kidneys threatened by insufficient blood or toxins
(Date:2/20/2017)... PA (PRWEB) , ... February 20, 2017 , ... ... collaborating to help health care providers better manage patient health risks, foster behavior change ... medication video library in the world, will present a demonstration of its video capability ...
(Date:2/20/2017)... ... February 20, 2017 , ... ReportingMD, a Population Health Software Company, is pleased to announce ... The new location will triple the size of the previous location while bringing life ... Sunapee, NH. , “We are excited to expand our footprint to better serve ...
(Date:2/20/2017)... , ... February 20, 2017 , ... ... care providers and health plan partners, announced during the 2017 Annual HIMSS ... enhancing care coordination for diabetic patients and integrating eye care into mainstream ...
(Date:2/19/2017)... , ... February 19, 2017 , ... ProBrand Glitch is a set of 30 glitch ... Glitch users can easily reveal any logo with a glitch reveal in just a few ... over the style and animation of each preset. Use these presets to add a uniquely ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... of disruptive innovation in the industry, according to the recent NEJM Catalyst Insights ... on surveys of the NEJM Catalyst Insights Council, a qualified group of U.S. ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Conn. , Feb. 17, 2017 Arvinas ... of drugs based on protein degradation, today announced the ... receptor (AR) PROTAC during a poster session at the ... (ASCO GU) in Orlando, FL. ... to validate our platform and the potential of PROTACs ...
(Date:2/17/2017)... and Markets has announced the addition of the "Drug-Eluting Stents - ... ... US, Canada , Japan , ... America , and Rest of World. Annual estimates and forecasts are ... is provided for these markets. Market data and analytics are derived from ...
(Date:2/17/2017)... , Feb. 17, 2017 ... health offerings at the  2017 HIMSS ... PHG,AEX: PHIA), a global leader ... broad range of population health ... health solutions, fully integrated in a highly ...
Breaking Medicine Technology: