Navigation Links
Research points to a new way to protect kidneys threatened by insufficient blood or toxins
Date:5/18/2009

AUGUSTA, Ga. - Better treatments for acute renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get enough blood or are exposed to toxins, researchers at the Medical College of Georgia report in the may issue of the Journal of Clinical Investigation.

Stress on kidney cells caused by vascular obstruction, trauma, chemotherapy, even antibiotics cause mitochondria - the cell's powerhouse - to "go to pieces," says Dr. Zheng Dong, cell biologist in the MCG Schools of Medicine and Graduate Studies and at the Charlie Norwood Veterans Affairs Medical Center.

Fragmentation sets in motion a chain of events that prompts kidney cells to commit suicide and leads to acute renal failure.

"When mitochondrial fragmentation is blocked, it can save the cells and the kidneys," he says.

Dr. Dong and his colleagues used an inhibitor of the natural fission process mitochondria use to multiply. They will further examine the cell death pathway - and try blocking it - in human kidney biopsies and eventually in whole organs. One of his goals is to develop safer, more efficacious drugs that can be given to patients in acute renal failure.

Acute renal failure, a disease with high mortality rates, is on the rise because of increasing cases of cardiovascular disease, diabetes and other health-related problems that prevent the kidneys from getting sufficient blood.

In addition to acute renal failure, Dr. Dong believes fragmentation inhibitors can improve preservation of kidneys extracted from a donor for transplant.

What these drugs may block is a rapid death march that only begins with the breakup. Next, two proteins, Bak and Bax, typically found at divergent places in the cell, work together to make pores in the mitochondrial outer membrane. Cytochrome c, a protein that normally helps mitchondrion breathe and produce fuel, escapes through the pores. Out of place, it becomes a deadly accomplice that activates suicide pathways. Interestingly, in a study published in 2007 in the Proceedings of National Academy of Sciences (USA), Dr. Dong's laboratory showed that mitochondrial fragmentation involves Bak but not Bax.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research points to a new way to protect kidneys threatened by insufficient blood or toxins
(Date:1/18/2017)... ... January 18, 2017 , ... Michael J. Hennessy ... for its Center for Biosimilars, announced Michael J. Hennessy Associates, Inc. President Michael ... field of biosimilars through thought leader interaction in, live video and interactive digital ...
(Date:1/17/2017)... ... January 17, 2017 , ... January is National Stalking Awareness Month (NSAM), now in ... the corners and commit the crime of stalking, a very real danger to many in ... overlooked factor in stalking and other crimes. , “Stalking: know it. Name it. Stop it.”—so ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting interview with medical expert ... that help everyone endure and pass through tough times, Dr. Bernie Siegel energizes ...
(Date:1/17/2017)... Chapel, Florida (PRWEB) , ... January 17, 2017 ... ... Connected City, a new 21st century approach to infusing high speed technology into ... an area exclusively dedicated to the advancement of healthcare and wellness in a ...
(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons from New ... eye care practitioners on the latest breakthroughs in the prevention, diagnosis and treatment ... Symposium, according to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer of ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Research and Markets has announced the addition of the ... to their offering. ... The global CINV drugs market to grow at a CAGR ... Surgery Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. To calculate ...
(Date:1/18/2017)... 17, 2017  With an annual growth ranging from 6% to 10%, ... (Jakarta International Expo, March 22-24, 2017) serves the industry by fostering the regional ... SEA 2017? Investment Forum ASEAN -- ... Richer conference content Enhanced business matchmaking program ... ...
(Date:1/18/2017)... ANTONIO , Jan. 18, 2017   Seno ... process of diagnosing breast cancer through the development of ... of Steve Miller as SVP of Engineering. ... Product Realization at FUJIFILM SonoSite, with headquarters in ... the majority of his 30-year career to the development ...
Breaking Medicine Technology: