Navigation Links
Research partnership will study how electronic medical records can address genetics of drug safety
Date:10/21/2009

Chicago (October 21, 2009) The International Serious Adverse Events Consortium (SAEC) announced today it will collaborate with the HMO Research Network (HMORN) to improve the safe use of drugs by exploring why the genetic makeup of some individuals makes them more likely to experience serious drug-related adverse events (SAEs). The SAEC is a novel, non-profit international research consortium. The HMORN is the nation's premier resource for population-based health care outcomes research.

The collaboration will diversify the SAEC methods for developing SAE research cohorts, which is essential to furthering research goals of the organization. It will determine the feasibility of using the HMORN's centralized clinical data warehouse to research the genetics of drug-induced serious adverse events. This warehouse includes data relating to inpatient admissions and emergency room and outpatient visits representing 14 million unique patients. The research collaboration will initially focus on three drug-induced SAEs: hepatotoxicity, serious skin rashes, and extreme weight gain in users of atypical antipsychotic medications.

Initially, the collaboration will involve six members of the HMORN: Geisinger Center for Health Research, Group Health Research Institute, HealthPartners Research Foundation, Kaiser Permanente Center for Health Research-Southeast, Kaiser Permanente Center for Health Research-Hawaii and Marshfield Clinic Research Foundation. Each HMO will use detailed clinical profiles to search for potential subjects to enroll into current and future SAE research projects. Accuracy and completeness of the data will be assessed, as well as methods to ensure that data are robust. The first phase of this collaboration is expected to take 12 months.

The collaborators hope to derive "cases" from electronic medical records (EMRs) and eventually compare their genetic and clinical data with those of healthy control groups. The goal is to identify genetic mutations that are associated with the SAE. Through this initial research, the Consortium hopes to provide a foundation for the next generation of studies that will validate the role of these genetic variations in the development of drug-related SAEs. In this phase of the collaboration, no individual health records or health information will be released by any of the participating institutions in connection with this research. To date, the SAEC has already made significant genetic discoveries in support of its mission. The HMORN-SAEC collaboration is expected to facilitate the discovery of additional genetic findings.

"Our efforts to date on drug-induced liver injury and serious skin rashes have leveraged traditional academic networks recruiting research subjects across a limited number of hospitals," said Arthur L. Holden, Chairman of the SAEC. "By working with these leading HMOs, all of which have sophisticated electronic medical records and outstanding clinical research capabilities, we hope to open up a new, more scalable research channel to enroll subjects into this vital research. Our goal is to increase the breadth and diversity of patients participating and to provide our clinical research collaborators with larger, more developed research cohorts more efficiently and effectively."

"Many adverse drug reactions are likely related in some way to genetic differences among patients," said Robert Davis, MD, director of the Kaiser Permanente Center for Health Research-Southeast and a member of the HMO Research Network. "If we can identify these differences before prescribing medications, we can help promote the safest use of medications. With our large and ethnically diverse populations, and the wide range of medications used, the HMORN is an ideal partner for this type of collaboration."


'/>"/>

Contact: Julian Teixeira
julian.teixeira@zenogroup.com
202-965-7808
Zeno Group
Source:Eurekalert

Related medicine news :

1. Improving schools for disabled students is NJIT researchers mission
2. Karmanos Cancer Institute Immunology Researcher Obtains Nearly $1 Million National Institutes of Health Grant
3. Researcher, physician and teacher Phil Gold to be inducted into the Canadian Medical Hall of Fame
4. Karmanos Cancer Institute Receives $3 Million Grant from The Herrick Foundation to Launch Challenge Initiative for Cancer Research
5. Detailed Results from RV 144 HIV Vaccine Trial Published Today in The New England Journal of Medicine and Presented at the AIDS Vaccine 2009 Conference Provide Insight for Future Research
6. GSA showcases groundbreaking aging research slated for Atlanta meeting
7. National Trauma Institute Announces $600,000 in Funding for Trauma Research
8. Yerkes researchers present at 39th Annual Society for Neuroscience Conference
9. More research needed on blast induced traumatic brain injury and vestibular pathology
10. Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research
11. Patent challenges reduce pharmaceutical innovation and productivity, researchers suggest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: