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Research on the effects of stem cell source and patient age on transplantation outcomes
Date:12/7/2008

e past few years, non-myeloablative transplants that require smaller and safer doses of chemotherapy and radiation have allowed stem cell transplants to be conducted in older individuals or other patients considered too weak to withstand conventional stem cell treatment regimens.

To better study age as a predictor of outcome in patients receiving stem cell transplants, data from the Center for International Blood and Marrow Transplant Research (CIBMTR) on 565 patients with acute myeloid leukemia and 551 patients with myelodysplastic syndromes were retrospectively analyzed for transplant-related mortality, engraftment, incidence of acute and chronic graft-versus-host disease, leukemia-free survival, and overall survival. Outcome data gathered from 1995 to 2005 were stratified into four groups by patient age for comparison: ages 40 to 54, 54 to 59, 60 to 64, and 65 and older.

The analysis found that there was no statistically significant difference in transplant-related mortality across age groups, and no overall difference in the occurrence of acute graft-versus-host disease (31-35 percent at 100 days) or chronic graft-versus-host disease (36-53 percent at two years). Rates of relapse were similar across all age groups (29-30 percent at three years). Additionally, no statistically significant impact of age was found for transplant-related mortality, leukemia-free survival, or overall survival. Type of disease and disease status at transplant were significant risk factors for leukemia-free survival and overall survival at one year and for transplant-related mortality and relapse at two years. Patients' general health and degree of tissue-type match between recipient and donor were also significant at two years for nearly all outcomes.


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Contact: Laura Stark
lstark@hematology.org
415-978-3505
American Society of Hematology
Source:Eurekalert

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