Navigation Links
Research on the effects of stem cell source and patient age on transplantation outcomes
Date:12/7/2008

111 were matched at seven HLA loci. In those receiving a peripheral blood stem cell transplant, 518 were matched at eight HLA loci and 210 at seven HLA loci. In those receiving cord blood transplants, 28 were matched at five or six HLA loci and 110 matched at four HLA loci.

The study found that there were fewer transplant-related deaths for matched peripheral blood and bone marrow transplants (27 percent and 26 percent, respectively) than as for mismatched peripheral blood, bone marrow, and cord blood transplants (42 percent, 37 percent, and 41 percent, respectively). Leukemia-free survival (LFS) and overall survival (OS) were highest after transplantation of matched peripheral blood (LFS: 43 percent; OS: 45 percent) and bone marrow (LFS: 46 percent; OS: 48 percent). These rates were lower after transplantation of mismatched peripheral blood (LFS: 33 percent; OS: 36 percent), bone marrow (LFS: 34 percent; OS: 38 percent), and cord blood (LFS: 33 percent; OS: 35 percent). Importantly, rates of transplant-related deaths, leukemia-free survival, and overall survival for the three types of mismatched transplants were similar even though cord blood transplants were mismatched at more HLA loci.

Notch-Mediated Expansion of Human Cord Blood Progenitor Cells Results in Rapid Myeloid Reconstitution in Vivo Following Myeloablative Cord Blood Transplantation [Abstract #212]
Colleen Delaney, MD, Fred Hutchinson Cancer Research Center, Seattle, WA

This phase I study found that cord blood that is cultured to increase the number of CD34+ stem cells prior to transplantation helped to decrease the time to engraftment in patients with acute myeloid leukemia.

Cord blood is a valuable source of hematopoietic stem cells as it has a higher concentration of these cells than is normally found in adult blood. However, as only a small quantity of blood can typically be obtained from an umbilical cord, resulting in fewer available
'/>"/>

Contact: Laura Stark
lstark@hematology.org
415-978-3505
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Super Saturday, the last Saturday before Christmas, is ... day in the 2014 holiday shopping season. , ... steady pre-Christmas stream of customers, ready to purchase marijuana ... definitely intend to take advantage…of the recreational cannabis as ... enjoying The Grass Station’s holiday sale on vape products. ...
(Date:12/22/2014)... December 22, 2014 In recognition of ... sales to Hero Reward, a local organization that provides ... , Located on a couple hundred acres ... Program offers lodging, world class fishing, hunting, hiking, horseback ... was founded several years ago to support U.S. Service ...
(Date:12/22/2014)... 7,178 small business owners and marketing professionals avoided ... opted instead to join Digital Marketer, an Austin, Texas ... annual “Black Friday Boot Camp”. , ... 5 hour online training event and raised $50,000 in ... Central Texas based charities dedicated to fighting childhood cancer. ...
(Date:12/22/2014)... 2014 NAPW honors ... of the Year. Ms. Foley is recognized with this ... most-recognized networking organization of professional women in the country, ... of Professional Women is a powerfully vibrant networking community ... , “As a nurse, I felt like I made ...
(Date:12/22/2014)... December 22, 2014 At the ... next month in San Antonio, esteemed experts ... dynamics that often stand in the way of ... , This premier faculty development opportunity is ... Leadership, whose mission is to assist nurse educators ...
Breaking Medicine News(10 mins):Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3
... May 28 In a world of internet savvy,patients ... scheduling,are readily available online. With a few clicks of ... friends and family and even buy,groceries! A patient,s experience ... be equally as user friendly., With the new ...
... mean development of new class of drugs, researchers say ... that inhibits HIV protease has been developed by researchers at ... necessary for HIV replication, is a common target in the ... HIV protease inhibitor compound to be developed in 20 years ...
... lead to more effective drugs to slow progression of ... gene that plays a role in Alzheimer,s disease in ... the neurodegenerative condition has been identified by U.S. researchers. ... 20 -- opens a new line of research that ...
... creases, saggy areas around the mouth and neck the ... are not inevitable. They result from a structural breakdown inside ... the growth of new, youthful collagen, University of Michigan scientists ... collagen collapse and possible renewal, based on more than a ...
... the University of Pennsylvania School of Medicine have shown ... decoy, receptor, binding growth factors that promote the progression ... lead to new drug designs for inhibiting cancer. The ... publication. , Many types of tumors grow because of ...
... athletes and non-athletes suffer from one or more components ... conditions that can lead to cardiovascular disease, according to ... in Milwaukee. , The study results were presented today ... by Anne Z. Hoch, D.O., associate professor of orthopedic ...
Cached Medicine News:Health News:Empowering Your Patients: Smile Dash Portal 'Bridges Gap' Between Dentists and Patients 2Health News:New Compound Slows HIV Replication 2Health News:Study IDs Gene for Late-Onset Alzheimer's 2Health News:Why some treatments rescue aging skin 2Health News:Why some treatments rescue aging skin 3Health News:Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers 2Health News:New study shows sedentary high school girls are at significant risk for future osteoporosis 2
(Date:12/19/2014)... 19, 2014 You,re visiting the dentist for ... when he or she says you need a root ... you may have several questions and feel apprehensive about ... know it,s nothing to worry about. The Pennsylvania Dental ... alleviate any anxiety the public may have surrounding this ...
(Date:12/19/2014)... , Dec. 19, 2014 Breckenridge Pharmaceutical, ... multi-product agreement with MSN Laboratories Pvt. Ltd. ( ... expect to commercialize several new ANDAs.  Under the terms ... the products exclusively to Breckenridge for the U.S. market, ... its label.  Breckenridge and MSN have agreed to develop ...
(Date:12/19/2014)... , Dec. 19, 2014 In today,s ... product,s web presence to reflect the needs of ... particular, must meet the needs of key stakeholders ... According to recent research by ... of the participating companies averaged more than $100,000 ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Building a Best-in-Class Pharma Global Brand Website 2
... Thyroid-stimulating hormone (TSH) is a 32 kDa ... the anterior pituitary gland [1]. The structure ... of the pituitary and placental gonadotropins, consisting ... identical between these hormones and a unique ...
... (T4) is the primary active hormone synthesized ... gland [1]. T4 is synthesized via a ... by the follicular cells, (ii) iodination of ... to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT ...
... primarily by 5-monodeioination of thyroxine (T4) in ... production occurs at a rate which is ... of T3 from the thyroid gland into ... to 80-100 micrograms/day for T4. In addition, ...
... Human Insulin-like growth factor binding protein-3 (IGFBP-3) is ... in postnatal serum, as a component of the ... IGFBP-3, a molecule of IGF-I or IGF-II and ... the actions of the IGFs. The molar concentration ...
Medicine Products: