Navigation Links
Research on obesity targets the brain's use of fatty acids
Date:1/4/2011

AURORA, Colo. (Jan. 4, 2011) - Researchers at the University of Colorado School of Medicine have created a new and exciting mouse model to study how lipid sensing and metabolism in the brain relate to the regulation of energy balance and body weight. The research team, led by Hong Wang, PhD, created mice with a deficiency of lipoprotein lipase (LPL) in neurons, and observed two important reactions. First, the mouse models ate less and second, they became sedentary. Because LPL is important to the delivery of fatty acids to the brain, these responses spotlight the importance of fatty acid delivery to the brain in the regulation of body weight.

"This work may have important impact in understanding the causes of obesity and providing new treatments for this epidemic of our time," said Robert H. Eckel, MD, corresponding and senior author of "Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity" which was published today in Cell Metabolism.

The genetically-modified mouse (NEXLPL) has a defect in the breakdown of dietary lipoprotein triglycerides into fatty acids in the brain. These mice became obese on a standard chow diet between three and six months. At that point, the mice ate less and were less active.

The research also looked at which areas of the brain have the greatest impact on regulating body weight and learned that the hypothalamus may be the key area to observe as NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity. AgRP/NPY cause increases in food intake and decreases in energy expenditure. Researchers also noted that the NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus. Overall, this research indicates that the lipoproteins are sensed in the brain by an LPL-dependent pathway and provide lipid signals for the central regulation of body weight and energy balance.


'/>"/>

Contact: Jacque Montgomery
jacque.montgomery@ucdenver.edu
303-928-9093
University of Colorado Denver
Source:Eurekalert

Page: 1

Related medicine news :

1. Einstein-Montefiore researcher will test nanoparticles against pancreatic cancer
2. CTO summit and left main coronary interventions course will feature latest research and techniques
3. FSU researchers helping electric-wheelchair users move more easily
4. Researchers measure quality of care in oral anticoagulation
5. Research Sheds Light on Starvation Hormone
6. Deadliest Cancer Getting Smaller Chunk of Research Dollars
7. U.S. Researchers Find New Way to Gauge Rare Genetic Condition
8. Researchers Find Links Between Sleep, Anesthesia and Coma
9. Researchers: Pay more attention to epilepsy
10. Dana Farber/Harvard Cancer Center awarded $11.7M grant to support prostate cancer research
11. UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology: