Navigation Links
Research leads to better understanding of peripheral neuropathy
Date:3/5/2013

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

Sufferers may experience 20 to 30 tumours at any one time and such numbers often lead to hearing loss, disability and eventually death. Those with NF2 may also experience peripheral neuropathy, which is when the nerves carrying messages to and from the brain and spinal column to the rest of the body do not work.

Peripheral neuropathy leads to further complications for NF2 sufferers, such as pain and numbness, muscle problems, problems with body organs and other symptoms of nerve damage, such as bladder problems, uncontrollable sweating and sexual dysfunction.

Researchers from Plymouth University Peninsula Schools of Medicine and Dentistry are part of an international research team which has for the first time identified the role of a tumour suppressor called Merlin in regulating the integrity of axons. Axons are nerve fibres which transmit information around the body and it is these are that damaged in peripheral neuropathy.

The research team showed that Merlin regulates a protein called neurofilament which supplies structural support for the axon.

A better understanding of this mechanism could lead to effective drug therapies to alleviate the symptoms of peripheral neuropathy in patients with NF2.

The results of the research is published this week in Nature Neuroscience.


'/>"/>

Contact: Andrew Gould
andrew.gould@pcmd.ac.uk
44-188-438-346
University of Plymouth
Source:Eurekalert

Page: 1

Related medicine news :

1. U of M researchers find wide variation in cesarean delivery rates among US hospitals
2. New Center for Open Science designed to increase research transparency
3. BUSM researchers use goal-oriented therapy to treat diabetic neuropathies
4. Researchers Describe 1st Functional Cure of HIV in Baby
5. Research Finds Use of Volpara Objective Breast Density Software from Matakina Helps Overcome the Limitations of Mammography for Women with Dense Breasts
6. Pediatric cancer charities partner to fund international collaborative research
7. Industry and academic researchers gather for innovative accelerating cancer cures research symposium
8. Researchers describe first functional HIV cure in an infant
9. Researchers discover how to shutdown cancers powerful master protein
10. Research and Markets - Drug Delivery in Cancer - Technologies, Markets and Companies - 2013 Report
11. Research: Brain cant cope with making a left-hand turn and talking on hands-free cell phone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... , ... February 06, 2016 , ... ... of eating disorder treatment helps to reduce the frequency and level of relapse. ... Recovery Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks of ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... of the company's lighter, sleeker next generation LYNX VR Indoor Trainer with multi-rider ... Improvements in design and manufacturing not only reduce the weight of the unit, ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... ... February 05, 2016 , ... Looking for a last-minute Valentine’s Day ... tips of your toes. Foot massage, whether administered by a professional masseuse or a ... The American Board of Multiple Specialties in Podiatry (ABMSP) has taken the ...
(Date:2/5/2016)... ... February 05, 2016 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... Wine Tasting Event at the La Gorce Country Club in Miami Beach on ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... -- Amgen (NASDAQ: AMGN ) will present at the ... 9:15 a.m. ET on Wednesday, Feb. 10, 2016, in ... , executive vice president and chief financial officer at Amgen, ... can be accessed from the Events Calendar on Amgen,s website, ... will also be available on Amgen,s website for at least ...
(Date:2/5/2016)... , Feb. 5, 2016  Syneron Medical ... aesthetic device company, announced today that William ... North America, is scheduled to participate in the ... Conference on February 11, 2016 in ... allow institutional investors to meet with the Mr. ...
(Date:2/5/2016)... CENTENNIAL, Colo. , Feb. 5, 2016  As ... about health. The multitude of recommended screenings and tests ... healthy aging a priority. However, for the majority of ... of proactive health planning. For the 37.5 million American ... time like the present to make hearing health a ...
Breaking Medicine Technology: