Navigation Links
Research leads to better understanding of peripheral neuropathy
Date:3/5/2013

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

Sufferers may experience 20 to 30 tumours at any one time and such numbers often lead to hearing loss, disability and eventually death. Those with NF2 may also experience peripheral neuropathy, which is when the nerves carrying messages to and from the brain and spinal column to the rest of the body do not work.

Peripheral neuropathy leads to further complications for NF2 sufferers, such as pain and numbness, muscle problems, problems with body organs and other symptoms of nerve damage, such as bladder problems, uncontrollable sweating and sexual dysfunction.

Researchers from Plymouth University Peninsula Schools of Medicine and Dentistry are part of an international research team which has for the first time identified the role of a tumour suppressor called Merlin in regulating the integrity of axons. Axons are nerve fibres which transmit information around the body and it is these are that damaged in peripheral neuropathy.

The research team showed that Merlin regulates a protein called neurofilament which supplies structural support for the axon.

A better understanding of this mechanism could lead to effective drug therapies to alleviate the symptoms of peripheral neuropathy in patients with NF2.

The results of the research is published this week in Nature Neuroscience.


'/>"/>

Contact: Andrew Gould
andrew.gould@pcmd.ac.uk
44-188-438-346
University of Plymouth
Source:Eurekalert

Page: 1

Related medicine news :

1. U of M researchers find wide variation in cesarean delivery rates among US hospitals
2. New Center for Open Science designed to increase research transparency
3. BUSM researchers use goal-oriented therapy to treat diabetic neuropathies
4. Researchers Describe 1st Functional Cure of HIV in Baby
5. Research Finds Use of Volpara Objective Breast Density Software from Matakina Helps Overcome the Limitations of Mammography for Women with Dense Breasts
6. Pediatric cancer charities partner to fund international collaborative research
7. Industry and academic researchers gather for innovative accelerating cancer cures research symposium
8. Researchers describe first functional HIV cure in an infant
9. Researchers discover how to shutdown cancers powerful master protein
10. Research and Markets - Drug Delivery in Cancer - Technologies, Markets and Companies - 2013 Report
11. Research: Brain cant cope with making a left-hand turn and talking on hands-free cell phone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2016)... ... May 29, 2016 , ... Whole Health Supply is happy to announce the ... available via Amazon.com. This new style of nail clipper has a wider jaw opening ... approximately 4mm and the actual handle is 2.5mm thick to accommodate the cutting force. ...
(Date:5/28/2016)... ... ... May 26, 2016- In search of the K. Warriors, Shaolin Institute is ... Warriors” on June 4, 2016 at Ashbury Hotel and Suites 600 West Interstate 65 ... by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), This is the 28th ...
(Date:5/27/2016)... Newark, NJ (PRWEB) , ... May 27, 2016 , ... ... been named as YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The ... to their workplace. For this year, Geri Boone, Director of the MLTSS (Managed Long-Term ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought ... industry, from leading advocates, associations and industry leaders such as Bioness. , ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... May 27, 2016 LabStyle Innovations ... Diabetes Management Tool, today announced that the Company,s Chief Financial ... MicroCap Conference being held June 1-2 in New ... held June 7-9 in Los Angeles, CA. ... recent corporate and operational milestones, including the U.S. FDA Clearance ...
(Date:5/27/2016)... TEL-AVIV, Israel , May 27, 2016 /PRNewswire/ ... KTOV), an innovative biopharmaceutical company focused on late-stage ... by Dexcel Pharma of pivotal batches ... Food and Drug Administration (FDA). This follows Kitov,s ... pivotal Phase III trial successfully met its primary ...
(Date:5/26/2016)... York , May 26, 2016 ... Research "Medical Waste Management Market - U.S. Industry Analysis, Size, ... waste management market in the U.S. was valued at US$ ... a CAGR of 3.4% from 2015 to 2023 to reach ... exhaustive analysis of current and emerging needle free drug delivery ...
Breaking Medicine Technology: