Navigation Links
Research identifies protein that regulates key 'fate' decision in cortical progenitor cells
Date:9/21/2012

hrough which DOCK7 expression affects the two essential but contrasting functions of RGCs. "Self-renewability of RGCs must be tightly balanced with differentiation for proper cortical development," says Van Aelst.

"The mechanism we discovered to be central in the determination of RGC fate, is called interkinetic nuclear migration, or INM," she continues, "and you can see it in action in the movies made by Drs. Wang and Yang."

In INM, an RGC cell nucleus visibly travels over the course of the cell cycle "upward" and "downward" between opposing sides of the apical-most region of the neuroepithelium, called the ventricular zone or VZ. Nuclei move away from the apical surface during the G1 phase, undergo S phase at a basal location in the VZ, and return to the apical surface during G2 to divide at the apical location.

It is DOCK7 that regulates this movement; in particular, the movement from the basal to apical location, the CSHL team has now demonstrated. On what appears to be the lower surface of the VZ, the apical surface, signals directing the RCG toward proliferation i.e., reproduction of other RGCs are dominant. On the upper or 'basal' side of the VZ, dominant signals coax the RGC to split into new intermediate progenitors or neurons.

Migration explained: DOCK7, TACC3 and centrosomes

"The cellular machinery that controls INM involves a protein complex of actin and myosin, called actomyosin, as well as microtubule-dependent systems," notes Dr. Wang. "We show how DOCK7 exerts its effects by antagonizing the microtubule growth-promoting function of a protein called TACC3." That protein, tellingly, is associated with the centrosome, the cellular organ that organizes microtubules, and regulates the growth of microtubules emanating from the centrosome, thereby coupling the centrosome and nucleus .

As Dr. Yang points out, DOCK7 acts by antagonizing the microtubule growth-promoting function of TACC3.
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mount Sinai researchers identify predictors for inpatient pain
2. Modeling Good Research Practices guidelines for modeling in health care research available now
3. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
4. Research prizes from the Carlsberg Foundation to researchers from University of Copenhagen
5. Can disclosure hurt the translation of research?
6. Doctors Biased Against Drug Company Research, Study Finds
7. Systems biologist receives $2.5 million Pioneer Award for genome research
8. Researchers identify possible key to slow progression toward AIDS
9. Research suggests promise of cell therapy for bowel disease
10. Scripps Research Institute receives $20 million to shed light on HIV drug resistance
11. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... may be able to convince your brain that healthy foods ... study included eight overweight and obese people who were enrolled ... people react to different foods. These participants were compared to ... weren,t in the program. Both groups had MRI brain ... months later. The scans revealed that the people in the ...
(Date:9/1/2014)... NY (PRWEB) September 01, 2014 More ... been added to a federal litigation that continues to ... Carolina, Bernstein Liebhard LLP reports. , A federal ... now filed over the widely-used cholesterol medication by plaintiffs ... drug. According to claims, Pfizer Inc. failed to adequately ...
(Date:9/1/2014)... Barcelona, Spain Monday 1 September 2014: Permanent atrial ... paroxysmal AF, according to research in more than 6 ... Thomas Vanassche from Belgium. The findings suggest that a ... help doctors to better estimate stroke risk. , Ischaemic ... EU, accounting for over a million deaths and many ...
(Date:9/1/2014)... September 01, 2014 In honor of National Take ... 22, Animal Emergency & Referral Center of Minnesota (AERC) is offering ... priority for their cats. , Many people don’t take their cat ... of a hassle,” but they wouldn’t decide not to take their ... a cavity. The same goes for pets. Just like people want ...
(Date:9/1/2014)... Daily Gossip reveals in it's review on Tattoo ... members access to thousands of professionally designed tattoo images ... to help both people who plan on getting a ... for inspiration in creating one of a kind models. ... visiting the official website at: http://www.dailygossip.org/atattoo-me-now-6444 . , ...
Breaking Medicine News(10 mins):Health News:Train Your Brain to Choose Fruit Salad Over French Fries 2Health News:South Carolina Litigation Adds 200 Lipitor Lawsuits in a Month, as Plaintiffs File Suits Alleging New-Onset Diabetes, Bernstein Liebhard LLP Reports 2Health News:South Carolina Litigation Adds 200 Lipitor Lawsuits in a Month, as Plaintiffs File Suits Alleging New-Onset Diabetes, Bernstein Liebhard LLP Reports 3Health News:Permanent AF doubles risk of stroke compared to paroxysmal AF 2Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 2Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 3Health News:Tattoo Me Now Review Reveals Unique Ideas for Tattoo Designs 2
... ongoing decline in the cancer death rate in the ... receive care that addresses the psychological and social problems ... psychological, emotional, and social side effects can increase patients, ... treatment. CANCER CARE FOR THE WHOLE PATIENT: MEETING ...
... October 16, 2007 -- Reducing the number of ... be more cost-effective than most public health and ... at Columbia University Mailman School of Public Health ... that class-size reductions would generate more quality-adjusted life-year ...
... 16 Expected to be,her family,s Halloween treat, Catharine ... pound, 10 ounces. Today, the five-year-old of,Allentown, Pennsylvania has ... who was born 16 weeks early, measuring only 12,inches ... half a million,babies born preterm each year in the ...
... (US Food Sources Preferred Over Imports), FRESNO, Calif., ... surveyed say their confidence in the food supply has,decreased ... conducted by,the California Olive Industry. The registered dieticians ... with 66% saying that when presented with a,choice, they ...
... NASHVILLE, Tenn., Oct. 16 HCA today announced the,appointment ... West Division,which is based in Las Vegas, effective Jan. ... retirement. As Far West Division President, Rogers will ... currently include nine,hospitals and seven ambulatory surgery centers with ...
... The Evening Will Feature Special Performances by John Legend, Joss Stone, ... ... The G&P Foundation for Cancer,Research will honor four outstanding individuals at ... Chief,Executive Officer of BET Networks Debra L. Lee, Chief Hematologic Oncology,Memorial ...
Cached Medicine News:Health News:Study shows reducing class size may be more cost-effective than most medical interventions 2Health News:March of Dimes Selects Pennsylvania Girl as 2008 National Ambassador 2Health News:Dieticians & Nutritionists Report Decreased Confidence in Food Supply 2Health News:Bryan R. Rogers Appointed President of Far West Division 2Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 2Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 3Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 4Health News:The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan 5
(Date:8/29/2014)... JORDAN, Utah , Aug. 29, 2014  BC ... Solutions, has acquired Polaris Medical Imaging, a leader in ... scanners. This strategic acquisition allows BC Technical to continue ... capabilities, specifically within MR and CT modalities. ... cost service," said Mark Alvarez , president and ...
(Date:8/29/2014)... 2014 Does your doctor know what you,re smoking?  ... recommended marijuana to the over 112,000 currently registered patients under ... of the other roughly 20,300+ active physicians listed with the ... it – even though a poll in February 2014 showed ... have tried it. "With marijuana legalization underway, ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
...  Long research and development cycles.  Low success of clinical ... information technology options.  It,s not just time and money; ... being wasted.   Such justifiable criticisms of ... the formation of a new company, RedOak Logic ...
... hospital patient room of the future is on display – ... that stand to benefit hospitals and patients nationwide. ... in Plainsboro, NJ, to replace its downtown Princeton facility, has ... of the new hospital,s proposed patient room in its existing ...
Cached Medicine Technology:RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 2RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 3RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 4Hospital Room of the Future Debuts in New Jersey 2Hospital Room of the Future Debuts in New Jersey 3Hospital Room of the Future Debuts in New Jersey 4
... Latex based reagent kit to detect Rheumatoid Factor ... the level of RF semi-quantitatively in the human ... includes antigen coated fine latex particles uniformly suspended ... squeezable dropping bottles, re-usable plastic slide, 50 uL ...
RFScan Latex Test Kit-100...
The Array 360 CEAL streamlines processes with computer enhancements and optimizes productivity by offering an exclusive design for aliquot samples....
ELISA kit for detection of Rheumatoid Factor....
Medicine Products: