Navigation Links
Research identifies a way to make cancer cells more responsive to chemotherapy
Date:5/23/2013

Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University explains why some cancer cells don't respond to chemotherapy, and identifies a mechanism to rectify that.

Dr. Shawn Li, PhD, and his team at Western's Schulich School of Medicine & Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 -a master regulator of cell death. The scientists found when Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53. The research is published in the May 23rd issue of Molecular Cell. A related research paper on the role of chemotherapeutic agents on regulating protein methylation, also from the Li lab, will be published in the June 7th issue of Molecular Cell, and is now online.

"If you don't have Numb in a cell, then the p53 can be degraded very quickly, and these cells become resistant to chemotherapy," explains Li, a professor of Biochemistry and Canada Research Chair in Cellular Proteomics and Functional Genomics. "So if we can prevent Numb from being methylated in cancer cells, then we will have the means to sensitize the cell to chemotherapy."

Now that he's identified the Set8-Numb-p53 pathway, Li is investigating various drugs to find a Set8 inhibitor which could be used as a novel breast cancer therapy alone, or in combination with other chemotherapy regiments.


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111
University of Western Ontario
Source:Eurekalert

Page: 1

Related medicine news :

1. Six Investigators Awarded Lyme Research Alliance Grants
2. Health2Go Announces Research That DHEA Helps Depression
3. Stryker Hip Lawsuit News: Bernstein Liebhard LLP Comments on Research Linking Femoral Stem Corrosion at Modular-Neck Junction with Local Soft Tissue Destruction
4. Researchers find common childhood asthma unconnected to allergens or inflammation
5. Researchers identify networks of neurons in the brain that are disrupted in psychiatric disease
6. U.S. Specialty Films Market Worth $8 Billion & Packaging Drives Industry by 2017 Says New Research Report at ReportsnReports.com
7. PhD Box Unveils Proposal Writing Services for Research Scholars
8. MarketResearch.com Report – Increased Cost of Albumin was Main Factor for Double-Digit Growth of Global Critical Care Market Between 2006 and 2012
9. HR Strategies Raises Over $6,300 for Cancer Research via Relay For Life
10. Fish Oil Pills Might Cut Diabetes Risk, Researchers Say
11. Alleviating hunger in the US -- researcher says, its a SNAP
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)... ... March 01, 2017 , ... The Industrial Designers Society of America (IDSA) ... awareness of the profession of industrial design (ID) and relaunching "What Is ID?" ... school students and counselors; parents; and the greater public. , Share details and photos ...
(Date:3/1/2017)... ... March 01, 2017 , ... ... to announce the release of its 2017 update to Compass, the popular ... and physician advisors. , Suitable for standardizing both new-hire on-boarding and annual ...
(Date:3/1/2017)... , ... March 01, 2017 , ... Grund® America ... Towels and Bath Rugs launching at the March 2017 International Housewares Show in Chicago ... rugs, which are made with the highest quality,100% OEKO-TEX and GOTS Organic Cotton material. ...
(Date:3/1/2017)... ... March 01, 2017 , ... ... increase colorectal cancer screening rates by supporting the 80% by 2018 initiative, led ... (CDC) and the National Colorectal Cancer Roundtable (an organization co-founded by ACS and ...
(Date:3/1/2017)... ... March 01, 2017 , ... MilfordMD Cosmetic Dermatology ... month of March for treatments aimed at tightening skin and contouring the neck. ... skin tightening, with 30 percent off all Thermage face and body treatments. March ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... 28, 2017 Persistence Market Research in ... Debridement Product Market 2016-2024," offers insights into developments ... North America that are significantly ... the overall market performance has been taken into ... focuses on developing different products to retain market ...
(Date:2/28/2017)... Intraocular Lens Market: Overview Read the full report: ... ... / opaqueness of the natural lens of the eye, which ... permanent loss of vision. Intraocular Lens is a type of ... Cataract is considered as one of the most common eye ...
(Date:2/28/2017)... , Feb. 28, 2017 The global gynecology surgical ... 2021 from USD 1.73 billion in 2016, at a CAGR ... ... http://www.reportlinker.com/p04734938-summary/view-report.html Major factors contributing to the growth ... diseases, increasing awareness on gynecological diseases, and rising government investments ...
Breaking Medicine Technology: