Navigation Links
Research identifies a promising new therapeutic target for aggressive breast cancer
Date:7/31/2012

Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models. The study led by Lynne-Marie Postovit of Western's Schulich School of Medicine & Dentistry looked at a protein called Nodal that is primarily found in embryonic or stem cells. Postovit discovered high levels of this protein in aggressive breast cancer tumors. Nodal was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread. The research is published online in the journal Cancer Research.

"We have determined that breast cancers, specifically those very aggressive, invasive breast cancers that spread, express an embryonic protein called Nodal and the expression of this protein is correlated with more blood vessels in the tumor. Blood vessels, many studies have shown, help to allow tumors to grow but also to spread throughout the body," says Postovit of the Department of Anatomy and Cell Biology. "In addition, we have shown that if we can target this embryonic protein, we can cause the blood vessels to collapse within the tumor, leading to decreased oxygen levels and tumor cell death. When tumors lack oxygen and nutrients they become what we call necrotic."

In the study, mouse models were designed to develop breast cancer tumors. Then, using a genetic modification, the researchers turned off the expression of Nodal. When they did that, the blood vessels in the tumor appeared to collapse, and the tumor was less aggressive. Nodal is on the outside of the cell, so it can be easily targeted by a number of mechanisms including antibodies. And because Nodal isn't expressed in normal tissue in the body, it would be possible to target just the cancer, allowing for better patient outcomes.

"Ultimately it would be nice to target Nodal in patients who already have quite advanced, well-vascularized tumors as a new option for
'/>"/>

Contact: Jeff Renaud
jrenaud9@uwo.ca
519-661-2111 x85165
University of Western Ontario
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
2. Wayne State research team finds possible clue to progression of MS
3. Tel Aviv University researcher says plants can see, smell, feel, and taste
4. ASTRO awards 5 research grants
5. State stem cell research funding agency awards $20 million to UCI, StemCells Inc.
6. Boys impulsiveness may result in better math ability, say MU researchers
7. Accelerated resolution therapy significantly reduces PTSD symptoms, researchers report
8. New research confirms efficacy of transcranial magnetic stimulation for depression
9. Research links sexual imagery and consumer impatience
10. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
11. SFU duos protein discovery links to cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 AttorneyOne.com, a recognized authority on law, ... the FDA on sterile convenience surgical packs . , ... convenience surgical packs, by Customed Inc., are recalled ... for the recall is a potential defect found due to ... and infection. The affected products’ manufacture dates were from January ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 The Florida ... the Hyatt Regency Orlando last week August 21-24 and ... returned as a presenter. , Dr. Greenstein ... the 21st Century was a standing room session; (2) ... – Doctors of Chiropractic Leading the Way in Injury ...
(Date:8/29/2014)... Canadian Healthy Vending , the largest healthy ... survey of its 200 operators from every region of ... appeal to Canadian consumer seeking refreshment at healthy vending ... five selling healthy snacks and top five selling healthy ... for consumers, employers, and families. Everyone wants to eat ...
(Date:8/29/2014)... 29, 2014 The Department of ... Administration (FDA), Center for Food Safety and Applied ... indefinite quantity (IDIQ) contract and the first two ... “Development, Modernization and Enhancement (DME) for FARM VI” ... , Overarching contract objectives include:, , ...
(Date:8/29/2014)... Under Section 946.300, Qualifications for the Certifying Physician, ... not…advertise in a cultivation center or a dispensing organization.” ... of Illinois has done is create a level of ... their care. The goal is to create a level ... typical prescription medications. Medical steering is a serious issue ...
Breaking Medicine News(10 mins):Health News:Sterile Convenience Surgical Packs by Customed, Inc. Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Sport and Spine Rehab’s CEO Presents at the Florida Chiropractic Association National Convention and Expo 2014 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 3Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 2Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 3Health News:Medical Marijuana Company Provides Solution for Illinois Marketing Regulations 2
... NANJING, China, Aug. 5 /PRNewswire-Asia/ -- Simcere Pharmaceutical ... supplier of branded generic and,innovative anti-cancer pharmaceuticals in China, ... quarter results on Monday, August 17, 2009,after the market ... Ren, and chief financial officer, Frank Zhigang Zhao, will,host ...
... , FORT LAUDERDALE, Fla., Aug. 5 ... leading provider of convenient at-home diet, fitness and healthy lifestyle solutions, today ... results after the U.S. equity markets close on Wednesday, August 12, 2009. ... conference call for investors the following day, Thursday, August 13, beginning at ...
... , PARSIPPANY, N.J., Aug. 5 DSM ... facility has received the( )Potent Compound Safety Certification from ... The Certification is for competency and proficiency in the ... potent drug products, and applies to the site,s potent ...
... , HACKENSACK, N.J., Aug 5 ReGen Biologics, a ... regarding its Menaflex collagen meniscus implant that were made in a ... party unaffiliated with the company. ReGen was unaware of ... on the Internet. The statements made in the release do ...
... , , , ... Michigan-based company dedicated to providing custom filling solutions, is now manufacturing ... for this product category in the market. The product line includes ... a growing trend in the hand-sanitizer market for more gentle formulas ...
... , SAN FRANCISCO, Aug. 5 ... to a study just published in the Journal of Gerontology ... risk for poor health outcomes and complications from other disorders. ... ongoing study of healthy adults aged 65 and older funded ...
Cached Medicine News:Health News:Simcere Pharmaceutical Group to Announce 2009 Second Quarter Earnings on Monday, August 17, 2009 2Health News:eDiets.com(R) to Report Second Quarter Fiscal 2009 Results on Wednesday, August 12, 2009 2Health News:DSM Announces SafeBridge(R) Potent Compound Safety Certification 2Health News:DSM Announces SafeBridge(R) Potent Compound Safety Certification 3Health News:ReGen Biologics Clarifies Recent Press about the Menaflex Device 2Health News:Brain Fitness Reduces Risk of Onset of Depressive Symptoms 2
(Date:8/28/2014)... Resources Group finds that the market for colorectal cancer (CRC) ... in the United States , ... Italy , Spain , the ... . The biosimilar erosion of Roche/Genentech/Chugai,s Avastin and Bristol-Myers Squibb/Eli ... of Eli Lilly,s Cyramza, Taiho Pharmaceutical,s Lonsurf, Alchemia,s HA-irinotecan and ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 Levi ... been commenced in the United States District Court for ... behalf of investors who purchased Galectin Therapeutics Inc. ("Galectin" ... 2014 and July 28, 2014. For more ... complaint alleges that during the Class Period the Company ...
(Date:8/28/2014)... , Aug. 28, 2014 Nonin Medical, ... leader in noninvasive medical monitoring, today announced that the ... Model 3231 OEM/eHealth finger pulse oximeter for use in ... pulse oximeter plugs into a telemedicine hub or kiosk ... pulse rate in pediatric to adult patients. The Model ...
Breaking Medicine Technology:The Colorectal Cancer Market Will Remain Steady at $7.7 Billion by 2023, With Biosimilar Erosion Of Key Agents Being Balanced Out By the Launch Of Premium-Priced Therapies 2SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2
... and Company (NYSE: LLY ) today issued ... and chief executive officer about his meeting today with ... job creation, American innovation and competiveness: "It,s ... and take part in this very important dialogue today ...
... Dec. 15, 2010 Johnson & Johnson (NYSE: ... Worldwide Chairman, Medical Devices & Diagnostics (MD&D) and Sheri ... Chairmen of the Executive Committee and join William C. ... in an expanded Office of the Chairman.  Both appointments ...
Cached Medicine Technology:Lilly Statement Regarding President Obama's Meeting With U.S. Business Leaders 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: