Navigation Links
Research identifies a promising new therapeutic target for aggressive breast cancer
Date:7/31/2012

Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models. The study led by Lynne-Marie Postovit of Western's Schulich School of Medicine & Dentistry looked at a protein called Nodal that is primarily found in embryonic or stem cells. Postovit discovered high levels of this protein in aggressive breast cancer tumors. Nodal was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread. The research is published online in the journal Cancer Research.

"We have determined that breast cancers, specifically those very aggressive, invasive breast cancers that spread, express an embryonic protein called Nodal and the expression of this protein is correlated with more blood vessels in the tumor. Blood vessels, many studies have shown, help to allow tumors to grow but also to spread throughout the body," says Postovit of the Department of Anatomy and Cell Biology. "In addition, we have shown that if we can target this embryonic protein, we can cause the blood vessels to collapse within the tumor, leading to decreased oxygen levels and tumor cell death. When tumors lack oxygen and nutrients they become what we call necrotic."

In the study, mouse models were designed to develop breast cancer tumors. Then, using a genetic modification, the researchers turned off the expression of Nodal. When they did that, the blood vessels in the tumor appeared to collapse, and the tumor was less aggressive. Nodal is on the outside of the cell, so it can be easily targeted by a number of mechanisms including antibodies. And because Nodal isn't expressed in normal tissue in the body, it would be possible to target just the cancer, allowing for better patient outcomes.

"Ultimately it would be nice to target Nodal in patients who already have quite advanced, well-vascularized tumors as a new option for therapy," says Daniela Quail, first author on the research and a PhD candidate in the Postovit lab. "Currently, patients like this don't have many options."

"In Canada, breast cancer continues to be one of the most common forms of cancer in women. Although new treatment methods have improved outcomes, a significant number of women still die from this disease", says Dr. Morag Park, Scientific Director of the Canadian Institutes of Health Research. "Research advancements, such as Dr. Postovit's, have contributed and will continue to contribute to the improvements around our understanding of cancer progression and treatment. I congratulate Dr. Postovit and the team on this advancement and its significant contribution to this field."


'/>"/>
Contact: Jeff Renaud
jrenaud9@uwo.ca
519-661-2111 x85165
University of Western Ontario
Source:Eurekalert

Related medicine news :

1. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
2. Wayne State research team finds possible clue to progression of MS
3. Tel Aviv University researcher says plants can see, smell, feel, and taste
4. ASTRO awards 5 research grants
5. State stem cell research funding agency awards $20 million to UCI, StemCells Inc.
6. Boys impulsiveness may result in better math ability, say MU researchers
7. Accelerated resolution therapy significantly reduces PTSD symptoms, researchers report
8. New research confirms efficacy of transcranial magnetic stimulation for depression
9. Research links sexual imagery and consumer impatience
10. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
11. SFU duos protein discovery links to cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... ... interview techniques, seeks to add a deeper understanding of the program, policy or ... and each answers different yet important questions. , In a new brief released ...
(Date:5/4/2016)... ... May 04, 2016 , ... Cirius, a provider of ... innovative Secure Messaging platform, which includes secure, private messaging, large file sharing, secure ... portfolio of patents around innovative features for securing, tracking, and controlling messages for ...
(Date:5/4/2016)... Camas, WA (PRWEB) , ... ... ... Agencies, a full service insurance provider serving families of Camas and Vancouver, ... The current campaign fundraises for the National Breast Cancer Foundation and their ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma community ... is set to return to the esteemed Quaker Ridge Golf Club in Scarsdale, ...
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, ... ... country’s leading private owners, developers and operators of commercial real estate proudly announced ... its 2015 Heart Health initiative. Team members portfolio-wide will continue Olshan Properties’ ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... TUCSON, Ariz. , May 3, 2016  As ... twice contracted rheumatic fever, which damaged his heart. ... But by June 2013, Shepherd,s heart was ... days from death. On June 20, 2013, the ... temporary Total Artificial Heart (TAH-t). Like a heart transplant, ...
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 /PRNewswire/ ... about the importance of extending care beyond the implant ... Scientific Sessions, May 4-7 in San Francisco ... tasked with continually delivering the highest quality of patient ... ensuring patients are cared for each and every tomorrow," ...
(Date:5/3/2016)... , May 3, 2016  Specialty Silicone ... tool that shows how a cleanroom works. The ... discussions about science and technology. ... "As a technology company, SSF enthusiastically supports the ... help educators foster the next generation of innovators. ...
Breaking Medicine Technology: