Navigation Links
Research highlights role of protein pair in obesity regulation
Date:2/12/2010

CINCINNATINew research by University of Cincinnati (UC) scientists implicates a new protein in obesity development and highlights a protein pair's "team effort" in regulating obesity and insulin resistance.

Jorge Moscat, PhD, chair of UC's cancer and cell biology department, says that proteins p62 and ERK are involved in adipogeneis, (the development of adipocytes, or fat cells). His new study shows precisely how this duo works together.

The study is published online in advance of print Friday, Feb. 12, 2010, in the journal EMBO Reports, and will appear in print in the March 1, 2010, edition.

Earlier research led by Moscat showed that removing or "knocking out" p62 in mice led to the development of obesity and insulin resistance in adulthood. These mice used less energy and created more fat cells than the control group, even with the same diet and activity levels.

Targeting p62 mutations or deficiencies seemed to be a logical next step for potential obesity treatments; however, Moscat says, p62 is not an easy target due to its lack of enzymatic action. In other words, it does not catalyze reactions in a way that would be key for the success of targeted drug therapy. In addition, missing or mutated p62 has also been linked to cancer development.

Moscat and his team instead decided to focus their attention on the action of another less-understood protein, ERK, which interacts with p62.

"Thoughts about ERK's role in obesity have been controversial," says Moscat. "One theory suggested that it was to restrain production of fat cells. Our study shows a much more devious role for ERK."

In the new study, Moscat and his team bred mice without p62 and ERK. These "double knockouts" did not develop obesity like the p62 knockouts did, indicating that ERK was the obesity-inducing culprit.

The team's findings show that p62 works to suppress the action of ERK, so without p62, ERK activity goes uncontrolled.

Moscat says that ERK serves as a better target for obesity therapies because it could be inhibited without affecting p62.


'/>"/>

Contact: Dama Kimmon
dama.kimmon@uc.edu
513-558-4519
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. MSU researcher linking breast cancer patients with alternative therapies
4. Researchers create drug to keep tumor growth switched off
5. Tiny fruit fly could offer big clues in fight against obesity, researcher says
6. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
7. New Research Examines Impact of Health Care Reform on Regional Health Plans
8. Prevention Is Key Research Goal for Premature Babies, Scientists Say
9. Stuttering Foundation Hails New Research
10. Gladstones Robert Mahley to receive Research!America advocacy award
11. International Diabetes Federation awards $2 million to 9 global diabetes research projects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... ... ... Seamild, the largest manufacturer of oats in China, is now aiming at global business ... recognized globally as one of the healthiest cereals, XieQingkui, the founder of Seamild, strongly ... to sow the seed of good karma. Buddhism spirit featuring benevolence and sacrifice are ...
(Date:1/21/2017)... ... January 21, 2017 , ... ... Relations, Dianne Travis-Teague, the electrifying line-up of events for its annual meeting “Coming ... friends, and community. “Coming Home 2017” will be held on Friday January ...
(Date:1/21/2017)... ... January 21, 2017 , ... Santa Rosa Orthopaedics ... Petaluma, located at 167 Lynch Creek Way. The Petaluma office features three comfortable ... and rehabilitation services and on-site x-ray services. Two multi-specialist orthopaedic surgeons ...
(Date:1/21/2017)... Texas (PRWEB) , ... January 21, 2017 , ... ... performed by Austin, Texas Periodontist Dr. Dan Holtzclaw in media for its creos™ ... features two surgeries performed by Dr. Holtzclaw in which he utilizes creos™ allo.gain™ ...
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between Goodwill® and Roadie, ... use or need, from clothes to couches to dressers and bicycles. Roadie — the ... to the nearest Goodwill donation center through February 28th. , “January is an ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan 20, 2017 Research and ... Aids Market (by Devices, Implant Types, OTC Amplifiers, Diagnostic Instruments), ... to their offering. ... Global Hearing Aids Market Sales Volume, Company Analysis ... fast-evolving, high-growth hearing aid industry. The growing prevalence ...
(Date:1/20/2017)... 20, 2017 Stock-Callers.com today evaluates the ... SGYP ), Novo Nordisk A/S (NYSE: NVO ), ... Therapeutics Holdings Inc. (NASDAQ: PTX ). These stocks ... 19 th , 2017, finishing near its session lows. As ... over 0.7%, while shares of health care companies in the ...
(Date:1/20/2017)... BUFFALO, N.Y. , Jan. 20, 2017 /PRNewswire/ ... health programs, has announced the launch of an ... to new guidelines on opioids and helps stem ... Opioids are often prescribed to treat chronic non-cancer ... disease) despite serious risks and lack of evidence ...
Breaking Medicine Technology: