Navigation Links
Research helps clarify how obesity leads to type 2 diabetes, cancer
Date:6/5/2014

molecules that can damage or kill cells. To help mitigate the damage, hypoxic cells activate HIF-1 alpha, which in turn shuts down the production of reactive oxygen species and signals inflammatory cells to migrate to the hypoxic areas.

"Organisms need to be able to temporarily adapt to the stress of hypoxic conditions until the situation changes, so when inflammatory cells see this kind of signal, they come to the hypoxic area to do their normal job, which is to basically eat damaged cells," Kim said.

In obesity, however, fat cells are in a chronic state of hypoxia.

"If you look at adipose, or fat tissue, in the obese, there is massive and chronic inflammation," he said. "It's a defense mechanism. The inflammatory cells are really good guys, but as obesity persists, inflammation becomes chronic.

"HIF-1 alpha is important for hypoxia adaptation, but it's constantly activated in the obese, and that's where it turns bad," Kim said. "In the obese, HIF-1 is aberrantly and chronically elevated and is the master regulator of ominous chronic inflammation."

To study the effect HIF-1 alpha might have on the development of insulin resistance and diabetes, Kim and his colleagues used genetic engineering techniques to completely remove, or "knock out" HIF-1 alpha from adipose tissue in obese mice.

"Once we knocked out HIF-1, everything got better," he said. "The fat cells survived and the mice remained obese, but we saw less inflammation in the fat tissue. These mice responded better to insulin than their normal counterparts, which means insulin sensitivity was improved and glucose tolerance was improved."

Kim said several pharmaceutical companies are developing HIF-1 alpha inhibitors to block the protein from functioning, which might one day result in medications to treat type 2 diabetes and insulin resistance in obese people. But the primary reason the pharmaceutical industry is already investigating HIF-1 alp
'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
University of Texas at Dallas
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIDA review summarizes research on marijuanas negative health effects
2. UO researchers use rhythmic brain activity to track memories in progress
3. FAPESP announces the SPRINT -- Sao Paulo Researchers in International Collaboration
4. A new approach to Alzheimers disease research
5. UCLA researchers identify new gene involved in Parkinsons disease
6. Researching how residential environment impacts preterm delivery in African-Americans
7. Notre Dame receives Gates grant for groundbreaking research in global heal
8. Moffitt researchers develop process to help personalize treatment for lung cancer patients
9. NIH task force proposes standards for research on chronic low back pain
10. Researchers to expand child exploitation web-crawler
11. Health Data Exploration network to spur research using personal health data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... ... Using the latest online digital technologies, happiness expert Kay Walker is on ... manage major depression. , “Suicide is 100% preventable. The problem is the medical community ... die needlessly everyday,” says Walker. “I’m out to end suicide. Some may say that’s ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... On July ... $2 billion in taxpayer money to fund the state’s large prison system, which has ... with the highest rates of incarceration. In light of President Obama’s recent reduction of ...
(Date:7/30/2015)... ... 30, 2015 , ... Ocean Hills Recovery has officially been accredited by CARF ... No recommendations means CARF found no areas in the OHR program that needed improvement, ... of all facilities receive. In addition, Ocean Hills was granted the maximum certification period ...
(Date:7/30/2015)... ... July 30, 2015 , ... The ... of the New Jersey Department of Health, has received a $2.9 million grant ... of the U.S. Department of Health and Human Services (HHS). NJII will help ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... InventHelp, ... from Texas, has designed a personal-care device that makes it easy to apply lotion ... could eliminate the need for assistance when applying lotion or medication to the back, ...
Breaking Medicine News(10 mins):Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 2Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2Health News:New Jersey Innovation Institute Awarded $2.9 Million Federal Grant to Advance Health Information Technology Services to Support Health Information Exchange 2Health News:InventHelp® Client Patents “My Back Buddy” – Device Could Apply Lotion to Hard-to-Reach Areas Easily 2
... Even non-obese people are at risk, researchers find , WEDNESDAY, ... major risk factor for obstructive sleep apnea, many non-obese people ... new study. , Among 5,426 non-obese adults (with a body-mass ... present in 54 percent. About half of those with the ...
... key target of an evolutionarily conserved protein that regulates ... in Nature , provides fundamental knowledge about key ... strategies and cancer therapies. Scientists have long ... fitness and longevity in most organisms ranging from single-celled ...
... Four suspects often found at the scene of the crime in ... in mice that are resistant to the disease, a team led ... Center reports in the June edition of Cancer Cell . ... the three protein receptors and the enzyme that makes them are ...
... June 10 As more and more employees become eligible ... and smaller percentage of them are actually signing up for ... of the Spencer,s Benefits Reports 2009 COBRA Survey. ... the 2008 plan year at companies covered by the survey, ...
... Seroquel, Zyprexa have been linked to certain health ... News) -- A U.S. Food and Drug Administration ... whether several powerful but controversial antipsychotic drugs be ... in question include new-generation "atypical" antipsychotics such as ...
... Education Newsletter Series for Healthcare Professionals , , ... syndrome characterized by localized, subcutaneous and/or submucosal swelling. Diagnosing ... there are multiple etiologies of this condition, all of ... healthcare professionals to understand the various causes of angioedema, ...
Cached Medicine News:Health News:Wistar Institute team finds key target of aging regulator 2Health News:Researchers identify four new targets for breast cancer 2Health News:Spencer's Benefits Reports COBRA Survey Finds Recession Takes Hold: More Were Eligible, Fewer Signed Up, Costs Stay High 2Health News:Spencer's Benefits Reports COBRA Survey Finds Recession Takes Hold: More Were Eligible, Fewer Signed Up, Costs Stay High 3Health News:Spencer's Benefits Reports COBRA Survey Finds Recession Takes Hold: More Were Eligible, Fewer Signed Up, Costs Stay High 4Health News:FDA Panel Mulls Newer Antipsychotics for Kids 2Health News:FDA Panel Mulls Newer Antipsychotics for Kids 3Health News:FDA Panel Mulls Newer Antipsychotics for Kids 4Health News:New Directions in Angioedema: A Focus on Etiologies and Clinical Approach 2
(Date:7/30/2015)... SAN DIEGO, July 30, 2015  ResMed Inc. (NYSE: ... ended June 30, 2015.  Revenue for the quarter was ... quarter ended June 30, 2014 (a 17 percent increase ... million, consistent with the quarter ended June 30, 2014. ... consistent with the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... Calif. , July 30, 2015  EP ... /Alcon executives have recently contacted the Company about ... begin as early as Monday, August 3, 2015.  ... quoted as saying that the coming electronic contact ... of dollars over the next several years.  Novartis ...
(Date:7/30/2015)... N.J. , July 30, 2015  Unichem Pharmaceuticals ... recalling one lot of Hydrochlorothiazide tablets 25 mg 1000-count ... initiated as a precautionary measure due to the identification ... the product. The risk associated with ... tablet is the increased probability of experiencing Clopidogrel,s side ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... American Pharmacists Month and CVS Caremark is recognizing ... their patients every day in its retail pharmacies, ... country. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) (Logo: ... time to recognize the significant contributions to health ...
... pharmaceutical and biotechnology sectors have long turned to the ... landscape. As the marketplace has evolved, leading organizations have ... as well. Specifically, effective market research groups ... one involved with shaping strategic objectives for key commercial ...
Cached Medicine Technology:CVS Caremark Recognizes Its 26,000 Pharmacists During October's American Pharmacists Month 2Best Practices, LLC Research Highlights Evolving Role of Market Research in Organizational Success 2
... communications software, including Remote Link and Central ... you the tools and choices to effectively ... Send patient tests via email, LAN or ... Philips Zymed Holter analysis applications are used. ...
... 12 gives you the detailed information you ... for your patients with palpitations, syncope and ... EASI Lead System, this transtelephonic cardiac event ... a derived 12-lead ECG. Comfortable for your ...
... the Zargis Acoustic Cardioscan Viewer Phonocardiogram (PCG). ... system that allows you to record, condition, ... an electronic stethoscope. The product acquires ... of up to four sites, and allows ...
... with the challenge of,controlling costs while ... patient data,management is critical. INFINITY modular,patient ... important clinical information,wherever you are in ... concept,makes your job easier. You can ...
Medicine Products: