Navigation Links
Research gives new hope to those with rare vascular cancer

A specific genetic alteration has been discovered as a defining feature of epithelioid hemangioendothelioma (EHE), a rare but devastating vascular cancer. These findings have also been used to develop a new diagnostic test for this blood vessel disease.

An international research effort led by Brian Rubin, M.D., Ph.D., of Cleveland Clinic's Pathology and Laboratory Medicine Institute and Lerner Research Institute, devised an innovative approach to reveal the genetic alteration thought to cause EHE, which is considered uncommon: it comprises less than one percent of all cancers. There are approximately 100 new cases in the U.S. each year.

The genetic aberration was detected in 89 percent (42 of 47) of EHE tumor tissues examined; none of the non-EHE vascular tumors contained the anomaly. The research, published in the Aug. 31, 2011, issue of Science Translational Medicine, was done in collaboration with Cleveland Clinic's Taussig Cancer Institute.

The authors defined the genetic aberration as a "translocation" between chromosomes 1 and 3, where chromosomes 1 and 3 exchange DNA fragments in such a way that the DNA is "transposed" onto opposite chromosomes. The result is that the swapped DNA encodes a unique, fused gene that contains components from each chromosome. Since genes are translated into proteins, the result of this unique gene is a correspondingly unique protein, whose function is deduced to be oncogenic (cancer-causing).

"This finding is the beginning of a new era for patients with EHE," said Dr. Rubin. "We firmly believe that the characterization of this genetic translocation will lead to a cure for EHE patients."

Identification of translocations in cancers is critical to understanding the molecular pathways at work within cancer cells. Understanding these molecular pathways allows cancer researchers to target them with specific drugs to disrupt the cancer. Thus, finding this translocation in EHE is a gateway to curing this cancer; using the techniques reported here may likewise provide breakthroughs for other cancers as well.


Contact: Dan Doron
Lerner Research Institute

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
(Date:11/27/2015)... ... 27, 2015 , ... The men and women on this ... in the country. They have overseen financial turnarounds, shown commitment to their community ... industry as a whole through their advocacy and professional efforts. , Becker's Hospital ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer ... incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product ... Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not only ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories and ... offered by healthcare staffing agency Aureus Medical Group . These fields, ... 2015 among those searching for healthcare jobs through the company’s website, ...
(Date:11/26/2015)... CA (PRWEB) , ... November 26, 2015 , ... ... a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly ... options. These classically-influenced trailer titles work with any font, giving users limitless opportunities ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/25/2015)... Nov. 25, 2015  Linden Care, LLC, a retail ... outcomes for patients suffering from chronic pain, said today ... Temporary Restraining Order (TRO) enjoining Express Scripts from unilaterally ... --> --> The ... its legal options. --> ...
(Date:11/25/2015)... 25, 2015  Henry Schein, Inc., the world,s largest ... dental, medical and animal health practitioners, will unveil at ... Henry Schein ConnectDental® Pavilion , which brings together for ... solutions designed to help any practice or laboratory enter ... for a schedule of experts appearing at the Pavilion. ...
Breaking Medicine Technology: