Navigation Links
Research gives new hope to those with rare vascular cancer
Date:8/31/2011

A specific genetic alteration has been discovered as a defining feature of epithelioid hemangioendothelioma (EHE), a rare but devastating vascular cancer. These findings have also been used to develop a new diagnostic test for this blood vessel disease.

An international research effort led by Brian Rubin, M.D., Ph.D., of Cleveland Clinic's Pathology and Laboratory Medicine Institute and Lerner Research Institute, devised an innovative approach to reveal the genetic alteration thought to cause EHE, which is considered uncommon: it comprises less than one percent of all cancers. There are approximately 100 new cases in the U.S. each year.

The genetic aberration was detected in 89 percent (42 of 47) of EHE tumor tissues examined; none of the non-EHE vascular tumors contained the anomaly. The research, published in the Aug. 31, 2011, issue of Science Translational Medicine, was done in collaboration with Cleveland Clinic's Taussig Cancer Institute.

The authors defined the genetic aberration as a "translocation" between chromosomes 1 and 3, where chromosomes 1 and 3 exchange DNA fragments in such a way that the DNA is "transposed" onto opposite chromosomes. The result is that the swapped DNA encodes a unique, fused gene that contains components from each chromosome. Since genes are translated into proteins, the result of this unique gene is a correspondingly unique protein, whose function is deduced to be oncogenic (cancer-causing).

"This finding is the beginning of a new era for patients with EHE," said Dr. Rubin. "We firmly believe that the characterization of this genetic translocation will lead to a cure for EHE patients."

Identification of translocations in cancers is critical to understanding the molecular pathways at work within cancer cells. Understanding these molecular pathways allows cancer researchers to target them with specific drugs to disrupt the cancer. Thus, finding this translocation in EHE is a gateway to curing this cancer; using the techniques reported here may likewise provide breakthroughs for other cancers as well.


'/>"/>

Contact: Dan Doron
dorond@ccf.org
216-312-0428
Lerner Research Institute
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Santa Barbara, CA (PRWEB) , ... January 21, ... ... through its Director of Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events ... enlivening festivities for alumni, family, friends, and community. “Coming Home 2017” will ...
(Date:1/20/2017)... Missoula, MT (PRWEB) , ... January 20, 2017 , ... Spectrum Aquatics Launches New ADA ... use, saving deck space. Since the lift is mounted on wheels, it can be wheeled ... a lock down kit, to fasten to the deck. "We have transformed the feedback from ...
(Date:1/20/2017)... ... January 20, 2017 , ... Bionic Sports Nutrition LLC, an American company devoted ... had a successful January ECRM Trade Show in Hilton Head, SC. , Bionic ... it to provide its products to all clients at reasonable prices. At the ECRM ...
(Date:1/20/2017)... Aliso Viejo, California (PRWEB) , ... January 20, 2017 , ... ... and easy to use inside of Final Cut Pro X," said Christina Austin - ... filmed on the RED Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and ...
(Date:1/20/2017)... ... ... examination of how God handles sin, including how to let go of lingering guilt and ... ten long years has been waiting to release this powerful insight about forgiveness that the ... the Lord for over twenty years, and he has been preaching and teaching the Word ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the ... and Future" report to their offering. ... This research service on the global ... and provides a snapshot of the key participants in the market. ... provided from 2016 to 2020. The market is expected to grow ...
(Date:1/20/2017)... , VAE, January 20, 2017 ... stark gestiegenen Bedarf an Nothilfe   Die internationale ... Platz für Hilfsgüter zu schaffen   ... und Premierminister der VAE sowie Herrscher von ... der internationalen Stadt der Hilfe (International Humanitarian City IHC) ...
(Date:1/19/2017)... YORK , Jan. 19, 2017 ... USD 233.7 billion by 2025, according to a ... market is anticipated to be predominantly driven by ... resulting into the large-scale production of new and ... the influx of drugs at an unprecedented rate ...
Breaking Medicine Technology: