Navigation Links
Research gives hope to detecting cancer in early stages

Research from Queen Mary, University of London has uncovered the mechanism which causes normal cells to develop into cancer, giving hope in the fight against one of the UK's biggest killers*.

The study, published in the online journal PLoS ONE today (26 March), investigated the role of the notorious cancer gene FOXM1.

Lead investigator Dr Muy-Teck Teh from Queen Mary, University of London, said the team found that the FOXM1 gene "brain washes" normal cells so they adopt a 'memory' pattern similar to cancer cells.

"This research has important clinical implications for early cancer diagnosis, prevention and treatment.

"We knew the FOXM1 gene is present in almost all different types of human cancers so we wanted to understand how excessive levels of it cause normal cells to become cancer-like."

Dr Teh's team used a gene-chip microarray technology to investigate the DNA 'memory' patterns in cells.

Normal cells inherit specific instructions or 'memory' patterns by masking and unmasking parts of their DNA. Maintaining the correct memory patterns is important for normal cell function - disturbing the memory pattern can lead to cancer formation.

"We knew that excess expression of FOXM1 can lead to cancer but its underlying mechanism was not clear," Dr Teh explained.

"We looked at normal human mouth cells and introduced high levels of FOXM1. The normal cells changed to adopt a memory pattern similar to those in mouth cancer cells and we identified a number of key pattern changes that may be responsible for initiating cancer formation.

"These pattern changes may lead to the identification of biomarkers which could be developed into new diagnostic tests. We are currently working towards developing a practical diagnostic test for detecting mouth cancer at very early stages."

The team's research, funded by the Wellcome Trust and the Facial Surgery Research Foundation, Saving Faces, means that it will be easier to detect changes in cells before they develop into cancer.

Consultant oral and maxillofacial surgeon Professor Iain Hutchison, founder of Saving Faces and co-author on the study, said: "We are excited about this finding as it means that we can now detect changes in cells way before they become cancer cells.

"Mouth cancer, if detected early when the disease is most receptive to surgical treatment, has a very high cure rate. Understanding how a gene such as FOXM1 can convert normal cells into cancer is an important step towards finding new diagnostic tests for early cancer detection."

This study builds on previous studies Dr Teh and his team has done on FOXM1. Published in 2009, Dr Teh found that nicotine could activate FOXM1 and that excessive levels could cause normal human mouth cells to develop into cancer. His research on FOXM1 was awarded 'Molecule of the Year 2010' by the International Society for Molecular and Cell Biology and Biotechnology Protocols and Research for its pivotal role in cancer stem-cell biology.


Contact: Bridget Dempsey
Queen Mary, University of London

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of ... 6, 2016, at Caesars Palace in Las Vegas with a pre-conference session on ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you stop ... not only fulfilling the needs of advisers and clients but going above and ... providing top-tier customer service. However, there's always room for improvement, which is why ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... the largest, most successful and prominent nonprofit healthcare organizations in the country. They ... involvement with various organizations, and helped advance the healthcare industry as a whole ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD ... for diagnostic imaging in the Waterloo region. Using the Ocean Platform, family physicians ... directly from their electronic medical record (EMR) without the need for redundant patient ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 27, 2015 /PRNewswire/ ... --> Medical ... response system (PERS) market is ... 5 years with APAC being ... to see a high CAGR ...
(Date:11/26/2015)... -- --> --> Juntendo ... optimal contrast weighting of MRI for patients with Multiple ... research agreement with SyntheticMR in order to use SyMRI in ... possible to generate multiple contrast images from a single scan ... thus making it possible to both fine tune images and ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: