Navigation Links
Research finding may lead to new treatments for obesity and Type 2 diabetes
Date:10/11/2011

CINCINNATIActivating a specialized type of fat, known as brown adipose tissue, may help combat obesity as well as result in better glucose control for type 2 diabetes, according to new research conducted by scientists at the UC Metabolic Diseases Institute.

The current UC study suggests that activating brown adipose tissue through targeted inhibition of the cannabinoid receptor 1, also known as CB1, could effectively reduce body weight and blood glucose by increasing calorie burning in brown adipose tissue.

Silvana Obici, MD, and her UC-based team report these findings online ahead of print Oct. 10, 2011, in Diabetologia, the journal of the European Association for the Study of Diabetes.

CB1 receptor antagonists were previously used in human weight loss drugs offered in Europe but were taken off the market due to significant neurologic side effects like depression.

"CB1 antagonists still hold promise for fighting obesity and diabetesthe challenge is finding one that does not engage the receptors in areas of the brain that control mood and still maintains its enormous calorie-burning properties," explains Obici, senior author of the UC study. "We have shown that the powerful effects of CB1 antagonists on brown adipose tissue are mediated by the sympathetic nervous system. With further study, this could lead to a more effective and safer drug strategy for glucose regulation and weight loss."

Obici is now conducting further studies to determine the specific location of the CB1 receptor in the sympathetic nervous system that activates the calorie-burning, glucose-consuming properties of brown adipose tissue.

"Our findings suggest that the capacity of brown adipose tissue to burn calories and consume glucose is impaired in obesity and type 2 diabetes. If we could find an effective and safe way to reactivate the brown adipose tissue's calorie-burning properties, this could represent a breakthrough in the search of more effective drugs against obesity and diabetes,," Obici adds.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. UCLA researchers develop new way to screen for brain cancer stem cell killers
2. UNC researcher to help lead new esophageal cancer network
3. Researchers find race disparity in post-hospital arrival homicide deaths at trauma centers
4. Researchers Assess What Works Best to Prevent PTSD
5. NIH funds continued research in suicide prevention in China
6. New research shows PET imaging effective in predicting lung cancer outcomes
7. Fox Chase researchers improve accuracy of IMRT delivery in post-prostatectomy patients
8. Researchers question key quality measure for asthma
9. Does MRI pose more than minimal risk in pediatric research?
10. Ohio State organizes research sharing between Brazil, US
11. Researchers from Boston University receive grant to develop improved virus detection system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... , ... The American Board of Quality Assurance and Utilization Review Physicians (ABQAURP) ... Health Care Quality and Management and Patient Safety. , It is with appreciation and ... also to the Health Care Quality and Patient Safety movements. Diplomates and Members lead ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... and the New MEDDEV 2.7/1 Rev. 4 Guidance, **An FDAnews Webinar**, April ... , How will the new EU MDR language change the way manufacturers ...
(Date:3/23/2017)... ... , ... “Beyond and Back”: a true-life testimony of tragedy and the miraculous ... Bonetta Rose, a wife, mother and grandmother committed to sharing her many spiritual adventures ... Rose‘s new book presents actual events in the life of her family, which validate ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... the existence of God. “A Respectful Response To Atheist Manifesto” is the creation ... married to his wife, Nancy, for sixty years. He holds graduate degrees from ...
(Date:3/22/2017)... ... March 23, 2017 , ... Death anxiety is unconscious ... profession, author Joy Nugent was inspired to write the book titled “ As Good ... inward desire to make sense of what she was experiencing at the bedside of ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 BioLineRx ... and immunology, announced today that it has acquired Agalimmune Ltd., ... Acquisition consideration consisted of a $6 million upfront payment, of ... BioLineRx shares. Additional future payments may be made based on ... ...
(Date:3/23/2017)... March 23, 2017 AbbVie, a global biopharmaceutical ... choreographer Julianne Hough is helping to raise ... the Know about ME in EndoMEtriosis . "   ... women to learn about and understand endometriosis, a disease ... and to address their symptoms with a healthcare professional. ...
(Date:3/23/2017)... -- During the "Nudging for Good" ... , My UV Patch, La Roche-Posay,s digital breakthrough ... ones, was awarded the Diamond Award by the ... "Nudging for Good" Award aims to honor brands ... to change behaviour and adopt a healthier and/or ...
Breaking Medicine Technology: