Navigation Links
Research finding may lead to new treatments for obesity and Type 2 diabetes

CINCINNATIActivating a specialized type of fat, known as brown adipose tissue, may help combat obesity as well as result in better glucose control for type 2 diabetes, according to new research conducted by scientists at the UC Metabolic Diseases Institute.

The current UC study suggests that activating brown adipose tissue through targeted inhibition of the cannabinoid receptor 1, also known as CB1, could effectively reduce body weight and blood glucose by increasing calorie burning in brown adipose tissue.

Silvana Obici, MD, and her UC-based team report these findings online ahead of print Oct. 10, 2011, in Diabetologia, the journal of the European Association for the Study of Diabetes.

CB1 receptor antagonists were previously used in human weight loss drugs offered in Europe but were taken off the market due to significant neurologic side effects like depression.

"CB1 antagonists still hold promise for fighting obesity and diabetesthe challenge is finding one that does not engage the receptors in areas of the brain that control mood and still maintains its enormous calorie-burning properties," explains Obici, senior author of the UC study. "We have shown that the powerful effects of CB1 antagonists on brown adipose tissue are mediated by the sympathetic nervous system. With further study, this could lead to a more effective and safer drug strategy for glucose regulation and weight loss."

Obici is now conducting further studies to determine the specific location of the CB1 receptor in the sympathetic nervous system that activates the calorie-burning, glucose-consuming properties of brown adipose tissue.

"Our findings suggest that the capacity of brown adipose tissue to burn calories and consume glucose is impaired in obesity and type 2 diabetes. If we could find an effective and safe way to reactivate the brown adipose tissue's calorie-burning properties, this could represent a breakthrough in the search of more effective drugs against obesity and diabetes,," Obici adds.


Contact: Amanda Harper
University of Cincinnati Academic Health Center

Related medicine news :

1. UCLA researchers develop new way to screen for brain cancer stem cell killers
2. UNC researcher to help lead new esophageal cancer network
3. Researchers find race disparity in post-hospital arrival homicide deaths at trauma centers
4. Researchers Assess What Works Best to Prevent PTSD
5. NIH funds continued research in suicide prevention in China
6. New research shows PET imaging effective in predicting lung cancer outcomes
7. Fox Chase researchers improve accuracy of IMRT delivery in post-prostatectomy patients
8. Researchers question key quality measure for asthma
9. Does MRI pose more than minimal risk in pediatric research?
10. Ohio State organizes research sharing between Brazil, US
11. Researchers from Boston University receive grant to develop improved virus detection system
Post Your Comments:
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: ) , ... , TwinLink™ - the first dual communication ...
Breaking Medicine Technology: