Navigation Links
Research explores how breast cancer spreads and new ways to treat it
Date:8/3/2011

sforming Growth Factor-beta) target gene called Jagged1 were identified. The study revealed a network of molecular crosstalk between tumor and bone cells using Jagged1 in tumor cells, EGFR in bone cells and TGFb released from damaged bone. Such pathological tumor-host tissue interactions eventually lead to tumor expansion and bone destructions. Targeting these pathways can reduce the development of bone metastasis and provide new avenues for managing the progression of the disease to the bones.

"We are excited to have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional potential targets for preventing and treating the disease," said Dr. Yibin Kang of Princeton University.

Rapid Translation of a Novel and Potent Vaccine in HER2+ Metastatic Breast Cancer Patients
Principal Investigator: Kim Lyerly, MD, Duke Medical Center

Approximately 20 percent of breast cancers are HER2+, meaning they over-express the HER2 gene, resulting in a particularly aggressive form of the disease.4 The first targeted treatment approved to treat HER2+ breast cancer was Herceptin (trastuzumab) in which the BCRP provided the early funding for research leading to the development of monoclonal antibodies against the HER2 receptor. However, despite its specificity, many patients experience resistance.5 Researchers at Duke University Medical Center evaluated a novel viral vector vaccine combination for testing in trastuzumab-refractory breast cancer patients.

Viruses attack and invade host cells by injecting their DNA as part of their replication process. In vaccine development, viruses can be used in this way to bring disease-fighting genetic information inside human cells.6 In this study, the two viral vectors, an adenovirus construct (Ad-HER2) and an alphavirus VRP construct (VRP-HER2), when used together in animal models have shown to elicit potent i
'/>"/>

Contact: Dayna Hochstein
dhochstein@spectrumscience.com
202-955-6222
US Department of Defense Congressionally Directed Medical Research Programs
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 2014 Activz Whole-Food Nutrition ... line offering natural silver healing support† in liquid ... century, silver has been used to support natural healing, ... is the most advanced version available. This latest formula, ... structure that supports the existing healing mechanisms in the ...
(Date:10/31/2014)... 2014 (HealthDay News) -- Sleep apnea may make it hard ... parked your car or left your house keys, a small ... apnea showed that this ability -- called spatial memory -- ... sleep, even when other stages of sleep weren,t affected. REM ... typically occur. "We,ve shown for the first time that ...
(Date:10/31/2014)... IL – New research suggests that insomnia is a ... and other unintentional fatal injuries. The results underscore the ... the National Healthy Sleep Awareness Project. , Results show ... a dose-dependent manner with the number of insomnia symptoms ... 2.8 times more likely to die from a fatal ...
(Date:10/31/2014)... Barbara, CA (PRWEB) October 31, 2014 ... holiday shoppers to find affordable but tasteful gifts for the ... 22nd Annual Early Bird Gift Giving Special , which ... off when they purchase Wine Club Gift membership. , ... take advantage of this special. Besides offering discounts, Gold Medal ...
(Date:10/31/2014)... 31, 2014 Urban Hydroponics, Inc. (OTCQB:URHY), ... announced it has signed a Binding Letter of Intent ... urban cultivation sector - Urban Cultivator Inc. (“Urban Cultivator”), ... W3 Metal Inc. (“W3 Metal” and together with Urban ... Pursuant to the LOI and an earlier non-binding term ...
Breaking Medicine News(10 mins):Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 3Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 4Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 5
... 11 , - With Photo , ... three ,mini, entrepreneurs today went,head-to-head to win a GBP2,000 investment from ... school children faced their toughest,challenge yet when they presented their big ... Shannon Stokes, 9, from Neith, South Wales, ...
... of healthcare employment Web sites offers recruitment and career opportunities to ... ... the midst of a slowing economy and as unemployment climbs, many ... ,"Healthcare continued to add jobs in February, with a gain of ...
... Records Critical to Improving Quality of U.S. HealthcarePLANO, Texas, ... PER ), the U.S. market leader for providing healthcare ... host a second comprehensive webinar about the impact that ... will have on the U.S. Healthcare industry. The ...
... March 11 The National Alliance on Mental Illness (NAMI) ... the state of mental health care in our state. ... D grade - a decline in its rating . Fourteen ... back including Michigan. "We are disappointed that Michigan,s mental health ...
... -- One in seven American adolescents is vitamin D deficient, ... of Public Health at Weill Cornell Medical College. The findings ... Pediatrics and were presented at the Pediatric Academic Societies, ... deficiency can interfere with bone mineralization, leading to rickets. In ...
... Truck crashes are a significant public health hazard ... with driver fatigue and sleepiness being major causes. ... obesity-driven testing strategies identify commercial truck drivers with ... and suggests that mandating OSA screenings could reduce ...
Cached Medicine News:Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 2Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 3Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 4Health News:Healthcare Industry Continues to Post Gains in a Down Economy 2Health News:Perot Systems Launches Webinar Series and Website Resources on Healthcare Stimulus Plan Provisions 2Health News:Perot Systems Launches Webinar Series and Website Resources on Healthcare Stimulus Plan Provisions 3Health News:Michigan's Mental Health Care System Gets a D Grade in Latest Study 2Health News:One in seven US teens is vitamin D deficient 2Health News:Obesity linked to dangerous sleep apnea in truck drivers 2Health News:Obesity linked to dangerous sleep apnea in truck drivers 3
(Date:10/31/2014)... YORK , October 31, 2014 ... Celgene Corporation (NASDAQ: CELG ), Bristol-Myers Squibb ... (NYSE: UNH ), Sanofi SA (NYSE: ... wealth members receive these notes ahead of publication. To ... http://www.analystsreview.com/7593-100free . , ,-- ,Celgene Corporation Research Reports ,On ...
(Date:10/31/2014)... 2014  Encision Inc. (OTCQB:ECIA), a medical device company ... burns in minimally invasive surgery, today announced financial results ... 2014. The Company posted quarterly net revenue ... $414 thousand, or $(0.04) per share. These results compare ... loss of $50 thousand, or $(0.01) per share, in ...
(Date:10/31/2014)... , Oct. 30, 2014 ... the electronic transmission of prescription related information ... E-Prescribing system allows a physician and nurse ... when a medication error occurs during pharmacy ... of applications. It provides complete medical lists, ...
Breaking Medicine Technology:Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 2Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 3Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 4Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 5Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 6Encision Reports Second Quarter Fiscal Year 2015 Results 2Encision Reports Second Quarter Fiscal Year 2015 Results 3Encision Reports Second Quarter Fiscal Year 2015 Results 4Encision Reports Second Quarter Fiscal Year 2015 Results 5E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2
... Therapy Services Holdings, Inc. ("Radiation Therapy Services" or the "Company") ... Wells Fargo Securities 2011 Healthcare Conference on Wednesday, June 22, ... held at the Intercontinental Hotel in Boston, MA. ... available by visiting the Events section of the Company,s Web ...
... ERT ), announced today that Keith ... present at the 2011 Wells Fargo Securities Healthcare ... in Boston. Interested parties may access ... at  http://www.ert.com . The webcast may also be ...
Cached Medicine Technology:ERT to Present at the 2011 Wells Fargo Securities Healthcare Conference on June 23, 2011 2
Spectrafuge 24D High speed, digital microcentrifuge. Precision control with digital display. Easy access 24-place rotor. Set and view speed in rpm or rcf. Quiet and cool running. StripSpin adapter fo...
... More Separating Power , Micromax produces forces up ... on 24 (1.5-2.0 mL) samples or 48 (0.5 ... brushless motor is designed for longevity and requires ... money. In addition, all controls are microprocessor based ...
... two centrifuges -- the world's most popular ... in one reliable, quiet, compact unit. It ... two separate centrifuges!, For your microcentrifuge needs, ... supplies you with the MicroMB centrifuge, microcentrifuge ...
... The Centrifuge 4-15C is designed to accommodate the ... the necessary force of more than 5600 x ... wide range of both fixed-angle and swing-out rotors ... 5 ml, 15 ml, and 50 ml tubes, ...
Medicine Products: