Navigation Links
Research explores how breast cancer spreads and new ways to treat it
Date:8/3/2011

sforming Growth Factor-beta) target gene called Jagged1 were identified. The study revealed a network of molecular crosstalk between tumor and bone cells using Jagged1 in tumor cells, EGFR in bone cells and TGFb released from damaged bone. Such pathological tumor-host tissue interactions eventually lead to tumor expansion and bone destructions. Targeting these pathways can reduce the development of bone metastasis and provide new avenues for managing the progression of the disease to the bones.

"We are excited to have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional potential targets for preventing and treating the disease," said Dr. Yibin Kang of Princeton University.

Rapid Translation of a Novel and Potent Vaccine in HER2+ Metastatic Breast Cancer Patients
Principal Investigator: Kim Lyerly, MD, Duke Medical Center

Approximately 20 percent of breast cancers are HER2+, meaning they over-express the HER2 gene, resulting in a particularly aggressive form of the disease.4 The first targeted treatment approved to treat HER2+ breast cancer was Herceptin (trastuzumab) in which the BCRP provided the early funding for research leading to the development of monoclonal antibodies against the HER2 receptor. However, despite its specificity, many patients experience resistance.5 Researchers at Duke University Medical Center evaluated a novel viral vector vaccine combination for testing in trastuzumab-refractory breast cancer patients.

Viruses attack and invade host cells by injecting their DNA as part of their replication process. In vaccine development, viruses can be used in this way to bring disease-fighting genetic information inside human cells.6 In this study, the two viral vectors, an adenovirus construct (Ad-HER2) and an alphavirus VRP construct (VRP-HER2), when used together in animal models have shown to elicit potent i
'/>"/>

Contact: Dayna Hochstein
dhochstein@spectrumscience.com
202-955-6222
US Department of Defense Congressionally Directed Medical Research Programs
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... hot Texas sun won’t keep kids from having fun outdoors ... had previously invested in a playground structure to augment their ... for an innovative solution to help protect children from excessive ... Rectangular Shade from APCPLAY as the perfect solution to providing ... shade measures 24’W x 34’H x 11’H to fully encompass ...
(Date:7/11/2014)... ASHBURN PSYCHOLOGICAL AND PSYCHIATRIC SERVICES , On July ... an intellectual disability or autism to have a special code ... to alert law enforcement or first responders that they are ... inspired by a central Virginia mother, Ms. Pam Mines, who ... autistic son, JP. During a news conference after the ...
(Date:7/10/2014)... acids had healthier joints than those fed diets high ... to Duke Medicine researchers. , The findings, published in ... on July 11, 2014, suggest that unhealthy dietary fats ... osteoarthritis. , "Our results suggest that dietary factors play ... link between obesity and osteoarthritis," said Farshid Guilak, Ph.D., ...
(Date:7/10/2014)... Thousands of researchers from more than ... 13-17 to reveal the latest study results, theories ... in dementia science. The Alzheimer’s Association International Conference ... kind. , As part of the Alzheimer’s Association’s ... generating new knowledge about dementia and fostering a ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 CBPartners, a ... industry, has launched a new website. The redesigned ... as increased access to the firm’s thought pieces, blog ... an ideal platform to showcase our insights, capabilities, and ... says CBPartners’ Chief Executive Officer, Cyrus Chowdhury. “An ...
Breaking Medicine News(10 mins):Health News:Cool Fun Under the Texas Sun: Godley Elementary School Purchases Shade Structure from APCPLAY© 2Health News:Recent Special “Autism” Code on Virginia Driver’s Licenses and ID Cards Goes into Law: Helpful or Discriminatory for Individuals on the Autistic Spectrum? 2Health News:Recent Special “Autism” Code on Virginia Driver’s Licenses and ID Cards Goes into Law: Helpful or Discriminatory for Individuals on the Autistic Spectrum? 3Health News:Omega 3 fatty acids lessen severity of osteoarthritis in mice 2Health News:CBPartners Announces New Website 2
... a new method to reform the mandible (lower jaw) of ... the study, Eric Moore, M.D., said that without reconstructive procedures ... be seen in mandible-removed oral cancer patients. ,‘We ... patients and a good tool for reconstructive surgeons,’ says Daniel ...
... foods targeted at improving women's health researchers are facing ... upon women's participation in food trials and studies. ... addressed this lack of available women's research at this ... EXPO?, the world's largest annual meeting on food science, ...
... Energy's Pacific Northwest National Laboratory and UCLA's David Geffen ... diseases// is linked to a natural by-product of oxidation ... Gehrig's disease and other brain disorders are a few ... that can be credited to oxidative stress, the cell ...
... the habit, they may gain about 20 pounds, according to ... commonly cited 5 pounds// to 15 pounds. ,The ... activity counseling along with smoking cessation programs, say study authors ... of the University of California, Berkeley. ,The authors ...
... announced on Wednesday that as many as three million ... Southern Africa. //WFP executive director James Morris said that ... a distribution problem. ,"Good harvests do not ... "Food and good nutrition are crucial in battling against ...
... that allows breast cancer cells to evade the body’s natural immune ... a study by Keck School of Medicine of USC scientists published ... the American Journal of Pathology, is the first to identify how ... – functions. ,“The important aspect of this study ...
Cached Medicine News:Health News:Jaw Reconstruction could be Possible in Oral Cancer Patients 2Health News:Jaw Reconstruction could be Possible in Oral Cancer Patients 3Health News:Women Doubtful of Food Research Benefiting Them 2Health News:Scientist Optimistic In Breakthrough For Causes Of Neurodegenerative Diseases 2Health News:Smokers are Prone to Weight Gain After Quitting 2Health News:Researchers Investigate Protein that Protects Tumors 2
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium ... technology market intelligence, the United States ... (TEO) device markets will expand moderately through 2022, ... segments. In particular, increasing interest in drug-eluting beads ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... India Drug Forecast and Market Analysis to ... PharmaPoint: Atopic Dermatitis - India Drug ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... Advanced Drug Delivery Systems -- Focus on ... STUDY OBJECTIVES A ...
Breaking Medicine Technology:US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... 2011 Reportlinker.com announces that a new market ... A Global Overview of Herbal/Traditional Products ... The quest for "safer and natural" options ... recognising the benefits of traditional medicine, consumers are ...
... March 14, 2011 Reportlinker.com announces that a ... catalogue: Hepatitis A Preventive Vaccines ... http://www.reportlinker.com/p0453473/Hepatitis-A-Preventive-Vaccines---Pipeline-Assessment-and-Market-Forecasts-to-2017.html ... Market Forecasts to 2017 SummaryGlobalData, ...
Cached Medicine Technology:Reportlinker Adds A Global Overview of Herbal/Traditional Products 2Reportlinker Adds Hepatitis A Preventive Vaccines - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Hepatitis A Preventive Vaccines - Pipeline Assessment and Market Forecasts to 2017 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: