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Research explores how breast cancer spreads and new ways to treat it
Date:8/3/2011

ORLANDO, Fla. August 3, 2011 Research into new methods to prevent and slow metastatic breast cancer will be presented this week at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program (BCRP). Approximately 6 percent of women with breast cancer will have metastatic disease upon diagnosis, and up to 30 percent of node-negative and 70 percent of node-positive breast cancers will relapse. 1 Common sites for breast cancer to spread are to the lungs, liver, brain and bones.

Studies presented at Era of Hope evaluate early research on a vaccine for HER2+ breast cancer that has stopped responding to treatment is entering human clinical trials later this year will also be discussed.

"New treatments for metastatic breast cancer are needed, as many patients become resistant to existing therapies," said Captain Melissa Kaime, M.D., Director of the Congressionally Directed Medical Research Programs (CDMRP), under which the BCRP is managed. "The novel studies presented at Era of Hope explore a number of promising pathways for treatment and new targets for preventing the spread of cancer."

Dissecting Tumor Stromal Interactions in Breast Cancer Bone Metastasis
Principal Investigator: Yibin Kang, PhD, Princeton University

Between 60 and 80 percent of late-stage breast cancer patients eventually face bone metastasis. 2 Discovering bone metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for breast cancer patients.

In this study, a multidisciplinary approach was applied to analyze the molecular basis of breast cancer bone metastasis, combining tools to analyze genomic information with animal models and clinical analysis of cancer metastasis. Candidate genes, including one dependent on EGFR 3 (Epidermal Growth Factor Receptor), and a TGFb (Tran
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Contact: Dayna Hochstein
dhochstein@spectrumscience.com
202-955-6222
US Department of Defense Congressionally Directed Medical Research Programs
Source:Eurekalert

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