Navigation Links
Research examines when benefits of screening mammography outweigh the harms for women in their 40s
Date:4/30/2012

WASHINGTON A new analysis suggests the benefits of mammography screening every other year outweigh the potential harms for women aged 40 to 49 who are at an increased risk of developing breast cancer -- a finding that could affect one out of every five American women. The researchers also found greater harms from screening done with digital mammography compared to film mammography. These findings, with contributions from three national research groups, are published in the May 1 issue of Annals of Internal Medicine.

"Our research suggests the benefit-harm balance is tipped in favor of every-other-year screening for women in their 40s who are at about twice the average risk of developing breast cancer," says the study's senior author Jeanne Mandelblatt, M.D., M.P.H., associate director for population sciences at Georgetown Lombardi Comprehensive Cancer Center. "The study also determined that the balance of benefits and potential harms in this same group is not favorable when increasing the frequency of mammography screening to once a year."

Conditions that confer a two-fold increase in risk include having extremely dense breasts (13 percent of the population aged 40 to 49) or having a first-degree relative with breast cancer (9 percent of the population aged 40 to 49). A review of factors that increase breast cancer risk levels is also published in this issue of Annals of Internal Medicine (Nelson, et. al.)

The researchers characterized benefits of screening as life-years gained and breast cancer deaths averted. Harms are defined as false-positive mammography examinations that sometimes lead to additional procedures, and pain and anxiety.

Mandelblatt says putting these results into practice will not be straightforward. "For example, the need to have a mammogram to determine breast density is an important point to consider in regards to implementing risk-based guidelines based on breast density." Mandelblatt says some groups might see this as a reason to recommend a baseline mammography.

In 2009, the U.S. Preventive Services Task Force (USPSTF) recommended mammography screening every other year for women aged 50 to 74 who have an average risk of developing the disease. The USPSTF concluded that for average risk women aged 40 to 49 years, biennial screening mammography offered a small benefit but considerable harms. Its findings were based in part on earlier research conducted by Mandelblatt and her colleagues.

This new study also finds small differences in benefits between film and digital mammography screening. However, digital mammography screening did result in substantially more false-positive results than film, and thus greater harm. The researchers say women would need to have at least a four-fold increase in risk of developing breast cancer to start screening at age 40 using digital mammography and still have the same balance of benefits and harms as average risk women aged 50 to 74, Mandelblatt explains.

Mandelblatt emphasizes that their research findings are based on models of the U.S. population and don't constitute a recommendation or advice for individual women, but rather provide new information for groups who make breast cancer screening guidelines.

"These results are not intended to guide clinical care, but to provide evidence to groups striving to individualize screening guidelines based on risk factors," she explains. "Ultimately, though, the decision of when to start screening and how often, and whether to have digital or film mammography should be left to women and their health care providers."

The new research resulted from the collaboration of and data from three national research groups the Breast Cancer Surveillance Consortium (BCSC), Cancer Intervention and Surveillance Modeling Network (CISNET) and the Oregon Evidence-based Practice Center.

Mandelblatt is an investigator with CISNET, which, for this study, utilized four well-established models from four international, independent research groups. The basic data used for the modeling were the same as those on which the USPSTF based their 2009 screening recommendations, but additional data regarding thresholds of risk was added for this new research. Cost was not a factor. BCSC, a research network of mammography registries in the United States, provided collaboration and some of the new data. As of 2011, the BCSC's database contains information on over 9.5 million mammograms, 114,000 breast cancer cases, and over 2.3 million women.

This study used comparative modeling. Separate modeling efforts often yield disparate results that are difficult to reconcile. A comparative modeling approach explores differences between models in a systematic way and results are compared across models. The models simulated life histories for populations of women estimating breast cancer incidence and deaths if they didn't receive screening and treatment. Then the models overlaid screening use and improvements in survival associated with treatment advances. Data interpretation was provided by the Oregon Evidence-based Practice Center. The researchers were able to establish a representation of the influence that breast cancer screening has on the simulated life histories based on risk levels.

Mandelblatt concludes, "Reducing the false-positive rate is crucial to improving the balance of benefits and harms for screening regimens for women of all ages."
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. How does the immune system fight off threats to the brain? New research yields fresh insight
2. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
3. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
4. Moffitt researcher publishes book on nutritional management of cancer treatment effects
5. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
6. Moffitt Cancer Center researchers working at frontiers of melanoma research
7. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
8. Research Gets Closer to Genetic Roots of Glaucoma
9. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
10. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
11. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... (PRWEB) , ... April 28, ... ... Standards Consortium (CDISC) announces today the open availability of a new CDISC ... and catalogs for registering clinical trials. This innovative standard will make it ...
(Date:4/28/2016)... ... April 28, 2016 , ... In many parts of the world, contamination ... mortality. This is particularly true in underdeveloped parts of Africa where clean sources of ... England’s campus in Tangier, Morocco, will examine this global health issue and consider how ...
(Date:4/28/2016)... ... 28, 2016 , ... One way to ignore solid evidence is to dismiss ... we toss the baby out with the bathwater when we ignore all studies because ... studies and otherwise making better use of education policy research. , “When readers heed ...
(Date:4/28/2016)... ... 28, 2016 , ... Point Source Audio® (PSA) , ... announced today that the US Patent Office has approved its patent submission that ... innovative design creates a lightweight and modular audio headset that has been said ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... containerization, today announced it will demonstrate its leading secure mobility workstation suite, SentinelSecure™, ... , Held at Hilton Union Square, this will be MobileIron’s 6th Mobile First ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... SHAWNEE, Kan. , April 27, 2016 /PRNewswire/ ... Martabano , a senior from the University of ... winner of the Bayer Excellence in Communication Award ... veterinary schools, which were awarded a total of ... Over the last four years, Bayer has provided ...
(Date:4/27/2016)... , April 27, 2016 ... over USD 2.14 billion by 2022, according to ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ... advancement affecting the efficiency and accuracy delivered by ... persistent demand for novel urinalysis instruments and consumables. ...
(Date:4/26/2016)... CHICAGO , April 26, 2016 Hill-Rom Holdings, ... to a management presentation at the Deutsche Bank 41 st ... at 2:50 p.m. EDT. You are invited to ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas ... one hour after conclusion of the live event and accessible ...
Breaking Medicine Technology: