Navigation Links
Research could put penicillin back in battle against antibiotic resistant bugs that kill millions
Date:3/12/2008

mesh that contributes to the bacterial cell wall. The presence of high levels of these dipeptide bridges in the peptidoglycan of Streptococcus pneumoniae is a pre-requisite for high level penicillin resistance.

The Warwick team were able to replicate the activity of MurM in a test tube, allowing them to define the chemistry of the MurM reaction in detail and understand every key step of how Streptococcus pneumoniae deploys MurM to gain this resistance.

The results will allow the Warwick team, and any interested pharmaceutical researchers, to target the MurM reaction in Streptococcus pneumoniae in a way which will lead to the development of drugs which will disrupt the resistance of Streptococcus pneumoniae to penicillin.

The same research also offers exciting possibilities to disrupt the antibiotic resistance of MRSA which uses similarly constructed peptide bridges in the construction of the peptidoglycan component of its cell wall. Therefore, thanks to this research, even MRSA could now be opened up to treatment by penicillin.

A further spin-off from this new MurM research, is that the Warwick led researchers are also able to readily reproduce every precursor step the bacterial cell uses to create its peptidoglycan. The tools developed at Warwick open up each step of the creation of the peptidoglycan (MurA, MurB, MurC etc, etc) used by an array of dangerous bacteria. This provides a valuable collection of targets for pharmaceutical companies seeking ways of disrupting antibiotic resistance in such bacteria.

The University of Warwick part of the research team have now established a new network of academics from the fields of chemistry, biology and medicine, as well as pharmaceutical companies to share and exploit this new treasure trove of targets which could help create a range of new designer antibiotic based treatments targeted at a range of bacteria that can cause significant health problems.


'/>"/>

Contact: Dr Adrian Lloyd
A.J.Lloyd@warwick.ac.uk
44-024-765-22568
University of Warwick
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Early bird doesnt always get worm, UNC researcher finds
2. Researchers develop a method to select eggs with the best chance of leading to successful pregnancy
3. USC researchers find benefit for lymphoma patients in combined PET-CT scanning
4. Lupus Advocates Urge Increased Funding for Lupus Research and Education
5. Researchers ID behavioral risk factors for head and neck cancers
6. Red-light cameras increase crashes, researchers find
7. Penn research offers road map to safer pain control, cost savings during colonoscopies
8. Leading researchers honored for progress in cancer prevention, detection and treatment
9. WaferGen Launches SmartSlide 200 Micro-Incubation System for Stem Cell Research and Cell Biology Applications
10. Wasserman Morris Initiates Research Coverage on Crdentia
11. Research shows promise for potential new gene therapy strategy for muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... innovative tool that captures heretofore hidden ways that cells ... protein that makes breast cancer cells more likely to ... cancer,s spread in part by blocking two other proteins ... suggests these two disease processes could have unexpected ties. ... 10 issue of Nature , points to the ...
(Date:7/9/2014)... Center paint a relatively optimistic picture of women,s chances ... spread to the chest wall or skin, but not ... regardless of size and whether they have involved lymph ... called "locally advanced" tumors, suggesting that they are a ... Locally advanced breast cancers of this and other types ...
(Date:7/9/2014)... The Miriam Hospital have found that people with ... depressed have difficulty sticking to a pulmonary rehabilitation ... women, and screening and brief treatment of depression ... study and its findings are published in print ... obstructive pulmonary disease is a common and often ...
(Date:7/9/2014)... has been a sharp increase in the number of ... the online, interactive service that allows patients to view ... schedule appointments, and renew prescriptions. , Over a six-year ... each year increased five-fold, while the number of ... to a study by Dr. David Gerber , ...
(Date:7/9/2014)... p>YouTube is for more than watching World Cup highlights, ... of skateboarders landing in unfortunate positions on railings. A ... Dermatology Online Journal shows that YouTube also ... with the public on topics of skin cancer and ... media is the future of how we communicate around ...
Breaking Medicine News(10 mins):Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Study of dermatology on YouTube shows new ways science reaches public 2
... a procedure wherein healthy cartilage is transplanted to fix ... OATS procedure) is superior to the standard of care ... such lesions may ultimately help to prevent the onset ... activities reliably. The study by Hospital for Special Surgery ...
... Climate change has impacts on forests, fields, rivers -- and ... these impacts more accurately, a comprehensive comparison of computer-based simulations ... the first time, sectors ranging from ecosystems to agriculture to ... framework. , The models will be provided by more than ...
... HealthDay Reporter , MONDAY, Feb. 6 (HealthDay News) -- Women ... be at increased risk of readmission to a psychiatric hospital ... study suggests. The findings, which appear in the February ... several previous studies showing that women who undergo abortion do ...
... MONDAY, Feb. 6 (HealthDay News) -- Treatment with three ... slightly increased risk of death, a new analysis suggests. ... taken into account by doctors and patients, according to ... analyzed the findings of 10 clinical trials that included ...
... 2012 -- The Fogarty Institute for Innovation announced ... Training Fellowship. This unique, year-long clinical training program ... will provide Fellows with broad exposure to ... emphasis on interventional training. Fellows will also engage ...
... genetics has been peeled back. A team of researchers ... Richard G. Pestell, M.D., PhD., FACP, Director of the KCC ... shown in a study published online Feb. 6 in the Journal ... genetic breakdown known as chromosomal instability (CIN). CIN is a known, ...
Cached Medicine News:Health News:New procedure bests standard of care for fixing damaged cartilage 2Health News:New procedure bests standard of care for fixing damaged cartilage 3Health News:Quantifying climate impacts: New comprehensive model comparison launched 2Health News:Quantifying climate impacts: New comprehensive model comparison launched 3Health News:Does Abortion in First Trimester Raise Risk of Mental Ills' Return? 2Health News:Does Abortion in First Trimester Raise Risk of Mental Ills' Return? 3Health News:Certain Cancer Drugs May Have Fatal Side Effects: Analysis 2Health News:Fogarty Institute for Innovation launches advanced endovascular training fellowship 2Health News:Drugs targeting chromosomal instability may fight a particular breast cancer subtype 2Health News:Drugs targeting chromosomal instability may fight a particular breast cancer subtype 3
(Date:1/15/2014)... 2014 Most osteoporosis patients want a choice in ... survey* sponsored by Mission Pharmacal Company. The survey, conducted ... online support community, revealed that 74 percent of osteoporosis ... a form other than a pill or a tablet. ...
(Date:1/15/2014)... LAWRENCEVILLE, N.J. , Jan. 15, 2014  Celsion Corporation (the ... it has received commitments from institutional investors to purchase ... common stock in an at-the-market registered direct offering, led ... Company entered into definitive purchase agreements with these investors ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2
... Phase III Studies With Ofatumumab, Zalutumumab and Zanolimumab, ... (OMX:,GEN) reports today that the last patient to ... in the pivotal Phase III clinical trial,of ofatumumab ... received the last scheduled treatment., In order ...
... Company to Host Conference Call/Webcast at 8:30 a.m. ... May 28 Alfacell Corporation,(Nasdaq: ACEL ) ... from its confirmatory Phase IIIb clinical trial of ... significance for the,primary endpoint of survival in unresectable ...
Cached Medicine Technology:Genmab Announces Updates on Phase III Cancer Studies 2Genmab Announces Updates on Phase III Cancer Studies 3Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial 2Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial 3Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial 4Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial 5