Navigation Links
Research could put penicillin back in battle against antibiotic resistant bugs that kill millions
Date:3/12/2008

Research led by the University of Warwick has uncovered exactly how the bacterium Streptococcus pneumoniae has become resistant to the antibiotic penicillin. The same research could also open up MRSA to attack by penicillin and help create a library of designer antibiotics to use against a range of other dangerous bacteria.

Worldwide Streptococcus pneumoniae causes 5 million fatal pneumonia infections a year in children. In the US it causes 1 million cases a year of pneumococcal pneumonia in the elderly of which up to 7% are fatal. This new research has completely exposed how Streptococcus pneumoniae builds its penicillin immunity and opens up many ways to disrupt that mechanism and restore penicillin as a weapon against these bacteria.

The research was led by Dr Adrian Lloyd of the University of Warwicks Department of Biological Sciences along with other colleagues from the University of Warwick, the Universit Laval, Ste-Foy in Quebec, and The Rockefeller University in New York. The research was funded by Welcome Trust and the MRC.

Penicillin normally acts by preventing the construction of an essential component of the bacterial cell wall: the Peptidoglycan. This component provides a protective mesh around the otherwise fragile bacterial cell, providing the mechanical support and stability required for the integrity and viability of cells of Streptococcus pneumoniae and other bacteria including MRSA.

The researchers targeted a protein called MurM that is essential for clinically observed penicillin resistance and has also been linked to changes in the chemical make up of the peptidoglycan that appear in penicillin resistant Streptococcus pneumoniae isolated from patients with pneumococcal infections.

The researchers found that MurM acted as an enzyme that was key to the formation of particular structures within the S. pneumoniae peptidoglycan called dipeptide bridges that link together strands of the peptidoglycan
'/>"/>

Contact: Dr Adrian Lloyd
A.J.Lloyd@warwick.ac.uk
44-024-765-22568
University of Warwick
Source:Eurekalert

6

GOOD

Page: 1 2

Related medicine news :

1. Early bird doesnt always get worm, UNC researcher finds
2. Researchers develop a method to select eggs with the best chance of leading to successful pregnancy
3. USC researchers find benefit for lymphoma patients in combined PET-CT scanning
4. Lupus Advocates Urge Increased Funding for Lupus Research and Education
5. Researchers ID behavioral risk factors for head and neck cancers
6. Red-light cameras increase crashes, researchers find
7. Penn research offers road map to safer pain control, cost savings during colonoscopies
8. Leading researchers honored for progress in cancer prevention, detection and treatment
9. WaferGen Launches SmartSlide 200 Micro-Incubation System for Stem Cell Research and Cell Biology Applications
10. Wasserman Morris Initiates Research Coverage on Crdentia
11. Research shows promise for potential new gene therapy strategy for muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... 21, 2013 Daily Gossip Magazine published well-documented ... readers and keep people informed on the latest weight loss ... have prepared an in-depth review of Kyle Leon’s ... for readers who want to lose weight or stay in ... Gossip the program was created by a popular fitness trainer, ...
(Date:5/21/2013)... GA (PRWEB) May 21, 2013 Patients of ... Care who have lost teeth due to gum disease and ... surgery for gum disease treatment with laser gum surgery. ... which have the highest success rate out of all tooth ... (LANAP) is a relatively new procedure cleared by the Food ...
(Date:5/21/2013)... 2013 Parker Waichman LLP, a national law ... defective medical devices, is offering remarks on the closing argument ... of Fred E. Taylor v. Intuitive Surgical, 09-2-03136-5, Superior Court, ... 2013, Bloomberg report noted that the plaintiff’s attorney, ... dealership” in how it deployed its strategy to train doctors ...
(Date:5/21/2013)... 2013) Prostaglandin analogues (PGAs), drugs which lower intraocular ... people with glaucoma, but their use is not without ... dryness, changes in eye color and other side effects. ... also cause upper and lower eyelid drooping and other ... described in PLOS ONE . , Researchers from ...
(Date:5/21/2013)... New York, New York (PRWEB) May 21, 2013 ... dedicated to protecting the rights of victims injured by ... the Journal of Bone & Joint Surgery on May ... (MRI) can be used to identify complications that occur ... have any symptoms of failure. ( http://www.jbjs.org/article.aspx?articleid=1684770 ) ...
Breaking Medicine News(10 mins):Health News:Customized Fat Loss Plan Review and Diet Secrets Revealed By Daily Gossip Magazine 2Health News:Shenk Dental Care Stimulates Bone Growth for Gum Disease Patients Seeking Dental Implants with Laser Gum Surgery in Atlanta, GA 2Health News:Da Vinci Robotic Surgery Lawsuit: Parker Waichman LLP Reacts to Plaintiff’s Attorney’s Closing Argument in Which He Describes Intuitive Surgical as a Car Dealership 2Health News:Da Vinci Robotic Surgery Lawsuit: Parker Waichman LLP Reacts to Plaintiff’s Attorney’s Closing Argument in Which He Describes Intuitive Surgical as a Car Dealership 3Health News:Glaucoma drug can cause droopy eyelids 2Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 2Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 3
... ... is a collaborative effort by the National Association of Certified Professional ... (CfM), International Center for Traditional Childbearing (ICTC), North American Registry of ... celebrate a recent the efforts of The MAMA Campaign to secure ...
... , NEW YORK, Dec. 4 Care Investment Trust Inc. ... announced that its Board of Directors has declared a dividend of ... on December 22, 2009 to common shareholders of record on December ... , Care Investment Trust Inc. is a real estate investment ...
... , PEMBROKE, Bermuda, Dec. ... ) today announced that Scott Carmilani,President and Chief Executive Officer, and ... presenting at the 2009,Goldman Sachs U.S. Financial Services Conference being held ... December 8, 2009. , About Allied World ...
... , KANSAS CITY, Mo., Dec. 4 The large, two-day ... (NAFC) in Kansas City on Wednesday and Thursday is not just ... has not seen a doctor recently. All participants in the health ... attended the three previous large free clinic events this fall in ...
... , WASHINGTON, Dec. 4 ... control health care costs, Leapfrog,s purchaser members point to ... best quality care in the nation while attaining the ... three rural hospitals have been named 2009 Leapfrog Top ...
... study shows that muscle cells grown in the lab can ... performed in dogs and rats, might ultimately help treat patients ... This technique may be used to strengthen sphincters, which are ... your intestinal tract. Weakness in these areas can cause gastrointestinal ...
Cached Medicine News:Health News:AquaNatal Birth Center Gives Away a Waterbirth Package to Celebrate the Successful MAMA Campaign 2Health News:AquaNatal Birth Center Gives Away a Waterbirth Package to Celebrate the Successful MAMA Campaign 3Health News:AquaNatal Birth Center Gives Away a Waterbirth Package to Celebrate the Successful MAMA Campaign 4Health News:Care Investment Trust Inc. Declares Quarterly Dividend of $0.17 Per Share 2Health News:Allied World to Present at the 2009 Goldman Sachs U.S. Financial Services Conference 2Health News:Free Health Clinic Event Is Not Just for the Sick 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 3Health News:Muscle cell infusion shown to strengthen sphincters in animals in Stanford study 2Health News:Muscle cell infusion shown to strengthen sphincters in animals in Stanford study 3Health News:Muscle cell infusion shown to strengthen sphincters in animals in Stanford study 4
(Date:5/21/2013)... CINCINNATI , May 21, 2013  Tom Daulton, CEO ... named Dealmaker of the Year by the Cincinnati ... Daulton, who was nominated by another local top executive who ... the Mammotome® brand from Ethicon Endo-Surgery in March of 2010. ... Deal Maker Awards program, presented by Huntington Bank, on May ...
(Date:5/21/2013)... PHILADELPHIA , May 21, 2013 ... and impressive new product developments at the Special Libraries Association ... years of unerring focus on product literature databases and workflow ... mark the occasion," said founding director Nigel Johnson ... developments of benefit to our clients and what better forum ...
(Date:5/21/2013)... -- Zacks.com announces the list of stocks featured in the ... discuss the latest news and events impacting stocks and ... include Actavis, Inc.,s (NYSE: ACT ), BP plc ... ), Petrobras (NYSE: PBR ) and Devon Energy ... http://photos.prnewswire.com/prnh/20101027/ZIRLOGO ) Get the most recent ...
Breaking Medicine Technology:Tom Daulton, Mammotome CEO, Named ACG Dealmaker of the Year 2Tom Daulton, Mammotome CEO, Named ACG Dealmaker of the Year 3Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 2Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 3The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 2The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 3The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 4The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 5
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: