Navigation Links
Research could lead to preeclampsia prevention
Date:11/6/2012

AUGUSTA, Ga. Excessive turnover of cells in the placenta may trigger an unnatural increase in blood pressure that puts mother and baby at risk, researchers say.

It's called preeclampsia, a condition that can develop after the 20th week of pregnancy, prompting an unhealthy increase in the mother's blood pressure that can result in premature delivery. Georgia Health Sciences University researchers want to know if dead placental cells in some cases produce an exaggerated immune response that constricts blood vessels and raises blood pressure.

"During pregnancy, there is a natural turnover of trophoblasts the main cell type in the placenta," said Dr. Stella Goulopoulou, a postdoctoral fellow in the Medical College of Georgia Department of Physiology at GHSU. "In pregnancies with preeclampsia, we see exaggerated rates of cell death compared to normal pregnancies."

When those cells die, they can release their mitochondria, or powerhouse, which then binds to a key receptor, Toll-like receptor 9, and causes an inflammatory response. Previous research has linked mitochondria released by damaged or dead cells to inflammatory responses associated with sepsis and heart failure.

"Blood vessels, like other tissues, have receptors that respond to mitochondrial DNA and other components of the mitochondria," Goulopoulou said. "DNA from the mitochondria can specifically activate Toll-like receptor 9, which is present in blood vessels. In our experiments, we found that activating Toll-like receptor 9 causes the blood vessels to constrict more than normal."

Goulopoulou has received a $25,000 Vision Grant from the Preeclampsia Foundation to study whether that is behind the generalized global inflammation and if that ultimately impairs the growing baby's supply of nutrients and oxygen. Vision Grants provide initial funding for novel lines of research to encourage young investigators to study causes and treatments of preeclampsia.

"The placenta is a dynamic tissue," she said. "We think it is the source of the mitochondria implicated in preeclampsia because it is the only tissue that undergoes such cell turnover during pregnancy. It also goes away, in most cases, when the placenta and baby are delivered."

Preeclampsia is characterized by high blood pressure, protein in the urine a sign the kidneys are stressed - and restricted growth of the fetus. It can also cause long-term damage to the mother's blood vessels, kidneys and liver. The condition causes approximately 76,000 maternal and half a million infant deaths worldwide each year. The symptomsheadaches, nausea, swelling, achescan be indistinguishable from those of ordinary pregnancy, which can complicate diagnosis. Risk factors include first pregnancy, multiple fetuses, obesity, maternal age greater than 35 and a maternal history of diabetes, high blood pressure or kidney disease. Researchers suspect many different causes for the condition, and although mild cases may be treated with dietary modifications, bed rest and blood pressure medication, birth is the only cure, Goulopoulou said.

Goulopoulou is looking for a molecular explanation for what triggers Toll-like receptor 9 to signal the body's inflammatory response, leading to vessel constriction. "When vessels in the uterus constrict, it inhibits blood flow, oxygen and nutrient supply to the baby," she said. "So, increased uterine constriction could be responsible for restricting the baby's growth." Women with preeclampsia often have underweight and underdeveloped babies.

By injecting mitochondria from placental cells into pregnant rats, Goulopoulou expects to see an inflammatory response and symptoms of preeclampsia. She will also measure the levels of mitochondrial DNA in the circulation of women with preeclampsia.

"One of the main objectives of this study is to discover why and how activation of Toll-like receptor 9 by mitochondrial DNA causes abnormal function of the blood vessels," she said. "If it is determined that this receptor is responsible, it could be a valid therapeutic target."


'/>"/>
Contact: Jennifer Hilliard Scott
jscott1@georgiahealth.edu
706-721-8604
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
2. NIH awards $20 million over 5 years to train next generation of global health researchers
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
5. Sexually abused boys at risk for more unsafe sex: UBC research
6. Researchers Find Gene Mutations That May Be a Key to Autism
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Researchers find evidence of banned antibiotics in poultry products
9. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
10. Scientific session and new research highlights
11. NJ stroke researchers report advances in spatial neglect research at AAN Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research could lead to preeclampsia prevention
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
Breaking Medicine Technology: