Navigation Links
Research consortium at CHLA receives $410,000 to study leukemia and lymphoma

LOS ANGELES (July 19, 2010) J. Eric Bubbers, PhD, of the Saban Research Institute at Childrens Hospital Los Angeles, has received a $410,000 grant from Phase One Foundation. The award will fund a "first in childhood leukemia" multi-site study in children with relapsed or refractory acute lymphocytic leukemia (ALL) or acute myelogenous leukemia (AML). Dr. Bubbers is the administrative director of Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL), an academic research consortium consisting of 33 member institutions in four countries.

"Both ALL and AML are cancers of the blood and bone marrow, with ALL being the most common cancer occurring in children," explains Dr Bubbers. "These diseases begin when a single cell changes from a normal cell to a cancer cell. Patients receive treatment chemotherapy and/or radiation with the hope of achieving remission. But sometimes that doesn't happen, or the remission doesn't last."

A child is in remission when he or she is not showing any signs or symptoms of disease. But sometimes the cancer cells return. This condition is called relapse. Other patients undergo treatment but not all the cancer cells are gone from their body. In this case, the patient has refractory disease. When a child has relapsed or refractory disease, different treatments may be required.

The TACL consortium is studying a new alternative treatment for these patients. Gene-targeted therapy, a type of personalized medicine, is based on the specific type of chromosomal changes occurring in a patient's cells. Certain genetic mutations, those of FLT3 and c-Kit, are associated with a particularly poor prognosis. This multi-center study will use a new drug that has been expressly optimized to inhibit FLT3 and c-Kit and has been effective in treating adults with these diseases. The goal of the phase I study is to determine a safe and biologically-active dose in young patients.


Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Page: 1

Related medicine news :

1. Concordia researcher leads study that finds kids reduce physical activity for heart patients
2. U of Us Janice Morse inducted into International Nurse Researcher Hall of Fame
3. Researchers Use Ecstasy to Treat PTSD
4. Licensed Florida Tech research makes lab work easier
5. New research finds major activation themes in denture-stomatitis
6. UC San Diego researchers find cause of metabolic disease -- and possible cure
7. Researchers cut years from drug development with nanoscopic bead technology
8. New research explores relief for xerostomia cancer patients
9. 5 awarded ASTRO research grants
10. Lu receives grant from Research to Prevent Blindness organization
11. NIH expands food allergy research program
Post Your Comments:
(Date:11/29/2015)... (PRWEB) , ... November 29, 2015 , ... While conventional ... kneeling or provide ready access to exercise weights. Fortunately, an inventor from Uniontown, Pa., ... THE TOMMY WALKER to enhance the benefits of a standard walker to improve the ...
(Date:11/29/2015)... ... November 29, 2015 , ... Key Housing, a top-rated corporate ... their December, 2015, featured apartment community: Epic. In showcasing this featured apartment community in ... tight Bay Area rental market to efficiently find housing suitable to their needs by ...
(Date:11/28/2015)... ... 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. EST, ... possible savings of up to 20% off orders $80 or more to free gifts with ... few hours. , As a competitive e-commerce website for skin care and cosmetic needs, customers ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... a safe and convenient way to dispense prescription medications at home, so he ... effective way to monitor and dispense prescription medications. In doing so, it could ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ... Breast Care to increase collaboration with sub-specialists around the ... --> Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ...
(Date:11/29/2015)... AMSTERDAM , Nov. 29, 2015  Strengthening its ... (NYSE: PHG, AEX: PHIA) today announced IntelliSpace Portal ... sharing, analytics and visualization platform that helps radiologists detect, ... the 2015 Radiological Society of North America Annual ... , IntelliSpace Portal 8.0 helps address the changing demands ...
(Date:11/29/2015)... Nov. 29, 2015   Royal Philips  (NYSE: PHG, ... solutions at the 2015 Radiological Society of North America ... McCormick Place in Chicago . Visitors ... the company,s broad portfolio of integrated Diagnostic Imaging, Clinical ... increase clinical performance, improve workflow and create a superior ...
Breaking Medicine Technology: