Navigation Links
Research consortium at CHLA receives $410,000 to study leukemia and lymphoma

LOS ANGELES (July 19, 2010) J. Eric Bubbers, PhD, of the Saban Research Institute at Childrens Hospital Los Angeles, has received a $410,000 grant from Phase One Foundation. The award will fund a "first in childhood leukemia" multi-site study in children with relapsed or refractory acute lymphocytic leukemia (ALL) or acute myelogenous leukemia (AML). Dr. Bubbers is the administrative director of Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL), an academic research consortium consisting of 33 member institutions in four countries.

"Both ALL and AML are cancers of the blood and bone marrow, with ALL being the most common cancer occurring in children," explains Dr Bubbers. "These diseases begin when a single cell changes from a normal cell to a cancer cell. Patients receive treatment chemotherapy and/or radiation with the hope of achieving remission. But sometimes that doesn't happen, or the remission doesn't last."

A child is in remission when he or she is not showing any signs or symptoms of disease. But sometimes the cancer cells return. This condition is called relapse. Other patients undergo treatment but not all the cancer cells are gone from their body. In this case, the patient has refractory disease. When a child has relapsed or refractory disease, different treatments may be required.

The TACL consortium is studying a new alternative treatment for these patients. Gene-targeted therapy, a type of personalized medicine, is based on the specific type of chromosomal changes occurring in a patient's cells. Certain genetic mutations, those of FLT3 and c-Kit, are associated with a particularly poor prognosis. This multi-center study will use a new drug that has been expressly optimized to inhibit FLT3 and c-Kit and has been effective in treating adults with these diseases. The goal of the phase I study is to determine a safe and biologically-active dose in young patients.


Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Page: 1

Related medicine news :

1. Concordia researcher leads study that finds kids reduce physical activity for heart patients
2. U of Us Janice Morse inducted into International Nurse Researcher Hall of Fame
3. Researchers Use Ecstasy to Treat PTSD
4. Licensed Florida Tech research makes lab work easier
5. New research finds major activation themes in denture-stomatitis
6. UC San Diego researchers find cause of metabolic disease -- and possible cure
7. Researchers cut years from drug development with nanoscopic bead technology
8. New research explores relief for xerostomia cancer patients
9. 5 awarded ASTRO research grants
10. Lu receives grant from Research to Prevent Blindness organization
11. NIH expands food allergy research program
Post Your Comments:
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017 ... mobile health and big data solutions, today announced that its MyDario product ... check your local TV listings for when The Dr. Oz Show airs ... The ... this month. ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: