Navigation Links
Research aims to starve breast cancer cells
Date:8/29/2011

AUGUSTA, Ga. The most common breast cancer uses the most efficient, powerful food delivery system known in human cells and blocking that system kills it, researchers report.

This method of starving cancer cells could provide new options for patients, particularly those resistant to standard therapies such as tamoxifen, Georgia Health Sciences University researchers said.

Human estrogen receptor-positive breast cancer cells thriving in a Petri dish or transplanted onto mice die when exposed to a drug that blocks the transporter, called SLC6A14, said Dr. Vadivel Ganapathy, Chairman of GHSU's Department of Biochemistry and Molecular Biology.

"It basically starves the cancer cell," said Ganapathy, corresponding author of the study published in the Journal of Biological Chemistry. The transporter can carry 18 of the known 20 amino acids, fuel all cells need in some combination. Amino acids enable cells to make proteins, which they need to function and survive. The cell type determines its amino acid needs and delivery system. Rapidly growing, dividing estrogen receptor-positive breast cancer needs nearly every amino acid so it makes the smart choice of utilizing the transporter that can deliver the biggest load, Ganapathy said.

SLC6A14 is the only transporter known to carry all 10 essential amino acids, essential because the body can't make them so they have to be delivered via the bloodstream from food. The transporter also takes eight of the nonessential amino acids along for the ride, Ganapathy said.

And it is a fast ride. The transporter has three energy sources instead of the usual one or two, he said.

Interestingly, SLC6A14 is expressed at low levels in most of the body. "There are specialized features of this transport system which could be used by every cell to its advantage but they do not seem to do that. It's expressed only at low levels in normal tissues," Ganapathy noted. While that may see
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research aims to starve breast cancer cells
(Date:3/3/2015)... Ann Arbor, MI (PRWEB) March 03, 2015 ... on NPR News Morning Edition, science correspondent Shankar Vedantam ... the University of Pennsylvania about the drastic decrease in hand-hygiene ... shift. He suggested that the problem could be solved in ... to perform hand hygiene when they enter and exit a ...
(Date:3/3/2015)... 3, 2015) (PRWEB) March 03, 2015 ... an innovator in the travel industry for the past ... expansion plan. To fulfill his vision for the future ... 400 fun, exciting and well-compensated positions as travel sales ... news sales center planned for the Boynton Beach, Florida ...
(Date:3/3/2015)... Retrofit , the comprehensive weight ... corporations, today announces the appointment of its new chief ... Mary Pigatti has recruited technology, healthcare and ... for the fast-growing company, which was recently named one ... 2015. , “Retrofit is thrilled to announce this new ...
(Date:3/3/2015)... March 03, 2015 According to ... http://www.idataresearch.com ), market saturation has made neurosurgery navigation ... the United States. Unit sales growth moderately increased ... as facilities replace older systems, and as new ... market is very much a replacement and upgrade ...
(Date:3/3/2015)... MA (PRWEB) March 03, 2015 The ... transformed the science of the little-known and incurable disease, ... its #CureFSHD campaign . The purpose of the ... FSHD, one of the most common forms of muscular ... off the campaign, today the FSH Society will begin ...
Breaking Medicine News(10 mins):Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 2Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 3Health News:First Class Vacations, Inc. Expansion Plan Creates 400 Jobs In South Florida 2Health News:First Class Vacations, Inc. Expansion Plan Creates 400 Jobs In South Florida 3Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 2Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 3Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 4Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 2Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 3Health News:Share to be Aware: FSH Society Launches #CureFSHD Campaign 2Health News:Share to be Aware: FSH Society Launches #CureFSHD Campaign 3
... has had a fascinating journey and as they wrap up the ... Blues, it is time for introspection for Bobby Gillespie. The band's ... // ,But after that there was a time when their ... that the "heroin hell" kicked in and it was such a ...
... The exposed super model and ramp queen Kate Moss has ... about getting exposed by the media about her cocaine addiction. // ... Kate Moss is very close to him and he has known ... said to him that it made her face the reality and ...
... from the University of Melbourne and La Trobe University have ... grains such as wheat and barley. With the stress being ... that this discovery would allow them to manipulate the fibre ... the production of beta-glucans, which is a major part of ...
... go on Phase I trial. It maybe as early as ... Shaw. ,Ms.Shaw was speaking at the conference ... for innovation and R&D.// There are close to 34 million ... always bear this in mind and develop products accordingly. ...
... Briton underwent a successful life-changing operation in India and returned ... for being// overweight. ,David Rogers, 62, from Abbeydale, ... overweight for the double hip and knee replacements that he ... he was about 37 kg too heavy for the surgery. ...
... found with breast tumors can predict the outcomes of the ... appearing in he April 1 issue of Clinical Cancer Research, ... risk for an early relapse of breast cancer. ... a potential marker of relapse in hormone-receptor positive breast cancer ...
Cached Medicine News:Health News:Overweight Briton Underwent Successful Surgery In India Being Denied By NHS 2
(Date:3/3/2015)... 03, 2015 Research and Markets ( ... "Global POC Diagnostics Market 2015-2019" report to their ... Global POC Diagnostics market to grow at a CAGR ... POC diagnostics are IVD devices and tools used ... setting. The use of these devices helps in the ...
(Date:3/3/2015)... 2015  Columbia Laboratories, Inc. (Nasdaq: CBRX ... a specialty pharmaceutical company focused on pharmaceuticals for women,s ... 27th Annual ROTH Conference, which will take place from ... Dana Point, California . Management,s presentation will ... Pacific Time (12:00 p.m. Eastern Time) in the Promenade ...
(Date:3/3/2015)... DUBLIN , Mar. 03, 2015 Research ... announced the addition of the "Global Ultrasound ... , The Global Ultrasound ... 5.79% over the period 2014-2019 Ultrasound ... sound waves. Ultrasound systems are extensively used by ...
Breaking Medicine Technology:Global POC Diagnostics Market 2015-2019 with Abbott Labs, Alere, Bayer Healthcare, Danaher, F. Hoffmann-La Roche & Johnson & Johnson Dominating 2Global Ultrasound Equipment Market 2015-2019: Rise in Number of MI Diagnostic Procedures with GE Healthcare, Phillips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2
... and Safety of ,First Generation, Antisense, BERKELEY ... GNTA ) announced the presentation of new data ... can be safely administered in high doses by ... presented by Dr. Anthony Tolcher, Director,of Clinical Research, ...
... Improvement in Hemodynamics and Delay Disease Progression -, ... Inc.,today announced positive results from two trials demonstrating ... a combination therapy,for the treatment of pulmonary arterial ... when given in combination with sildenafil,is well-tolerated and ...
Cached Medicine Technology:Genasense(R) Can be Administered by Brief High-Dose IV Infusion 2Genasense(R) Can be Administered by Brief High-Dose IV Infusion 3Genasense(R) Can be Administered by Brief High-Dose IV Infusion 4Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension 2Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension 3
... series SV stereomicroscopes are of ... to their mature modular design ... job in hand. This is ... demanding routine applications will appreciate, ...
6.3X Zoom Ratio - Boasting magnifications from 0.8X to 5X, the twin zooming objective optical system developed exclusively by Nikon provides a zoom ratio of 6.3:1. Clickstops at 1X intervals allow ob...
10:1 Zoom Ratio - The parallel optical system of the SMZ-1000 has a 10:1 zoom with clickstops at 1X intervals. It features a zoom range of 0.8X to 8.0X and total magnification (depending on eyepieces...
Fixed Versatility - With a diverse selection of body tubes, stands, lighting techniques and Nikon's world-renowned optics, this modular microscope can be configured to fit nearly any application....
Medicine Products: