Navigation Links
Research aims to prevent diabetic kidney failure
Date:11/4/2011

The enzyme arginase-2 plays a major role in kidney failure, and blocking the action of this enzyme might lead to protection against renal disease in diabetes, according to researchers.

"We believe these arginase inhibitors may be one of the new targets that can slow down the progression of, or even prevent the development of, end-stage renal disease," said Alaa S. Awad, assistant professor of nephrology, Penn State College of Medicine.

In the United States diabetes is the leading cause of end-stage renal disease -- kidney failure -- causing nearly 45 percent of all cases. Currently the treatment for diabetic patients likely to develop end-stage renal disease includes blood pressure and glucose control therapy and life-style changes.

The researchers tested two different sets of diabetic mice to try to prevent kidney failure. They gave one set of mice -- genetically diabetic -- a potent arginase inhibitor; the other set of mice -- induced to be diabetic -- were genetically unable to produce arginase-2. Both sets of mice showed no signs of kidney failure during the test period.

The body naturally produces varieties of arginase. The liver produces arginase-1, while the kidneys produce arginase-2, which leads to kidney failure. The researchers did not detect arginase-1 in the kidneys of the mice, and they have not yet developed an arginase inhibitor that can differentiate between the two forms of the enzyme.

"These findings indicate that arginase-2 plays a major role in induction of diabetic renal injury and that blocking arginase-2 activity or expression could be a novel therapeutic approach for treatment of diabetic nephropathy," the researchers report in the current issue of Diabetes.

One of the symptoms of diabetic nephropathy is albuminuria -- losing protein in the urine. The researchers found that the mice protected from arginase-2 were also protected from albuminuria.

People with diabetes and diabetic nephropathy o
'/>"/>

Contact: Victoria M. Indivero
vmi1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... (PRWEB) December 26, 2014 The ... CAGR of 7.2% to reach $5,756.0 million by ... the microscopy market. The electron microscopes product segment ... the forecast period. , Rising focus on nanotechnology, ... growth of the microscopy market. , Get Full ...
(Date:12/25/2014)... 25, 2014 Product liability lawsuits filed ... recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in ... Order issued in the U.S. District Court, Northern District ... an open conference on January 7, 2015, at the ... in West Palm Beach, Florida. The Conference is scheduled ...
(Date:12/25/2014)... December 25, 2014 Recently, BellasDress ... on all its wedding dresses. BellasDress has chosen their ... for gift choices for the holiday season. , ... pick suitable wedding gowns here at discount prices. The ... experience at its website. , “All our ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, ... illnesses can receive effective, less expensive care from a clinic ... a team of dedicated health care professionals, a new study ... and need either hospitalization or a trip to the emergency ... clinic at the University of Texas in Houston versus usual ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 AngelWeddingDress.com tries ... to the online realm. Today, the business has introduced ... a site-wide prom dress promotion. , The new prom ... each and every dress lover. They are specially designed ... 2015 prom dresses should visit its website before ...
Breaking Medicine News(10 mins):Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2
... FLEMINGTON, N.J., Sept. 9 HCD Research announced ... Barack Obama,s speech on health care reform tonight to obtain ... care reform. , , (Logo: ... HCD Research will conduct the study using its MediaCurves.com(R) website ...
... , LAKE MARY, Fla., Sept. 9 ... specialty pharmacy providers, was again chosen as one of "Central ... consecutive year that Axium has received this recognition. , ... the top 100 privately held companies in Central Florida. Axium ...
... , PRINCETON, N.J., Sept. 9 ... the opening of new clinical development offices in Sao Paolo, Brazil and ... a comprehensive range of services across Latin America. Earlier this year, Covance ... will support staff in these countries, Central America, and the Caribbean, as ...
... Extract used in 1918 pandemic may have antiviral properties, scientists ... with a particularly malodorous sap has components that show great ... scientists report. , The plant, Ferula assa-foetida , grows ... "Dung of the Devil" due to its ill-smelling sap. But ...
... , SOUTHFIELD, Mich., Sept. 9 The Wild West ... health screenings. While national and local regulations cover finger sticks and ... standards and monitors on-site health screenings or flu shot programs. ... a new white paper from wellness screening provider Summit Health, Inc. ...
... , , PITTSBURGH, Sept. ... nonprofit organizations in Pennsylvania and beyond to assist programs supported by ... Volunteer Grant Program, which reinforces the company,s appreciation for employees who ... their missions in the community. , , ...
Cached Medicine News:Health News:Research Firm will Obtain Americans' Reactions to the President's Speech on Health Care Reform 2Health News:Axium Healthcare Pharmacy, Inc. Has Been Chosen as One of 'Central Florida's Golden 100 Companies' for the Fifth Year in a Row 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 3Health News:Summit Health Helps Employers Navigate the 'Wild West' of Flu Shots and Workplace Health Screenings 2Health News:Highmark Inc. Awards $7,500 to 15 Pennsylvania Nonprofit Organizations 2Health News:Highmark Inc. Awards $7,500 to 15 Pennsylvania Nonprofit Organizations 3Health News:Highmark Inc. Awards $7,500 to 15 Pennsylvania Nonprofit Organizations 4
(Date:12/22/2014)... -- ConvaTec, a privately-held medical products and technologies company, today ... Executive Officer of the company, effective December 22, 2014. ... "The Board of Directors of ConvaTec thanks Mr. Berger ... three years," said Magnus Lundberg , the Chairman ... the company is well positioned for the future."  The ...
(Date:12/22/2014)... and STOCKHOLM , Dec. ... (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced that ... of the European Medicines Agency (EMA) has adopted a ... histolyticum) for the treatment of adult men with Peyronie,s ... at least 30 degrees at the start of therapy. ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah ... brief providing a summary of the 2015 marketplace ... enrollment trends.  According to a ... Planning and Evaluation, Department of Health and Human ... enrolled in individual medical plans through the Marketplace ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Insights into the Marketplace and Individual Market Growth 2
... Solos Endoscopy, Inc. (OTCPK: SNDY) announced today that the ... one hundred fifty million (150,000,000) common shares held by ... Convertible Preferred Shares. The common shares held by the ... back to the Company treasury. This transaction represents a ...
... Va., Feb. 14, 2012 The 60 Plus Association ... to weigh in with the Federal Trade Commission (FTC) ... and Medco Health Solutions, two pharmacy benefit managers (PBMs) ... some Medicare Part D plans. 60 Plus is a ...
Cached Medicine Technology:Solos Endoscopy, Inc. Announces Retirement of 150 Million Common Shares 2The 60 Plus Association Asks Congressional Leaders To Weigh In Against Controversial Health Care Merger 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: