Navigation Links
Research Uncovers Clues to Lymphoma
Date:6/24/2008

Findings from mouse model could lead to new therapeutic targets

TUESDAY, June 24 (HealthDay News) U.S. researchers say they've spotted an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer.

In experiments with mice, researchers at the National Jewish Medical and Research Center, Denver, found that the B-cell receptor on the surface of B-cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. They also found that disrupting signals from the B-cell receptor can inhibit tumor growth.

Oncogenes are genes thought to encourage cancer. It was already known that the oncogene MYC played an important role in the development of lymphomas. It wasn't known whether the B-cell receptor on the surface of B-cells also played a crucial role.

The new findings, which may help lead to new treatments, were published in the June 24 issue of the journal PLoS Biology.

"Non-Hodgkin lymphomas, about 90 percent of which are B-cell lymphomas, have become 85 percent more prevalent in the past 20 years, the only major form of cancer to experience such growth," team leader Yosef Refaeli, assistant professor of pediatrics, said in a prepared statement. "Our findings have pointed to the B-cell receptor and its signaling pathways as a very promising therapeutic target for B-cell lymphomas."

Non-Hodgkin lymphoma is a cancer of immune system cells known as T-cells and B-cells. Each year in the United States, about 66,000 new cases of non-Hodgkin lymphoma are diagnosed, and about 19,000 people will die of the disease.

For their research, Refaeli and colleagues created a new mouse model of lymphoma.

"Research into B-cell lymphomas has been hampered by the lack of a good mouse model. The mouse we created gives us a very good, predictive model of B-cell lymphomas, which can be used to explore not only these and related cancers, but also autoimmune disease and basic immunology," Refaeli said.

More information

The U.S. National Cancer Institute has more about Non-Hodgkin lymphomas.



-- Robert Preidt



SOURCE: National Jewish Medical and Research Center, news release, June 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
Breaking Medicine Technology: