Navigation Links
Research Uncovers Clues to Lymphoma
Date:6/24/2008

Findings from mouse model could lead to new therapeutic targets

TUESDAY, June 24 (HealthDay News) U.S. researchers say they've spotted an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer.

In experiments with mice, researchers at the National Jewish Medical and Research Center, Denver, found that the B-cell receptor on the surface of B-cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. They also found that disrupting signals from the B-cell receptor can inhibit tumor growth.

Oncogenes are genes thought to encourage cancer. It was already known that the oncogene MYC played an important role in the development of lymphomas. It wasn't known whether the B-cell receptor on the surface of B-cells also played a crucial role.

The new findings, which may help lead to new treatments, were published in the June 24 issue of the journal PLoS Biology.

"Non-Hodgkin lymphomas, about 90 percent of which are B-cell lymphomas, have become 85 percent more prevalent in the past 20 years, the only major form of cancer to experience such growth," team leader Yosef Refaeli, assistant professor of pediatrics, said in a prepared statement. "Our findings have pointed to the B-cell receptor and its signaling pathways as a very promising therapeutic target for B-cell lymphomas."

Non-Hodgkin lymphoma is a cancer of immune system cells known as T-cells and B-cells. Each year in the United States, about 66,000 new cases of non-Hodgkin lymphoma are diagnosed, and about 19,000 people will die of the disease.

For their research, Refaeli and colleagues created a new mouse model of lymphoma.

"Research into B-cell lymphomas has been hampered by the lack of a good mouse model. The mouse we created gives us a very good, predictive model of B-cell lymphomas, which can be used to explore not only these and related cancers, but also autoimmune disease and basic immunology," Refaeli said.

More information

The U.S. National Cancer Institute has more about Non-Hodgkin lymphomas.



-- Robert Preidt



SOURCE: National Jewish Medical and Research Center, news release, June 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
Breaking Medicine Technology: