Navigation Links
Research Takes Aim at Pancreatic Cancer

Discovery and testing in mice may lead to better detection and treatment

SATURDAY, April 18 (HealthDay News) -- An active receptor found in certain pancreatic cancers might offer hope for treatment of the often fatal disease.

A third of human pancreatic cancers looked at by Johns Hopkins University researchers contained a malfunctioning phosophorylated epidermal growth factor receptor (pEGFR), which previous studies had noted as being active in some lung cancers. When mice with this type of pancreatic cancer were given erlotinib, an EGFR-inhibitor drug approved for lung cancer treatment, the pancreatic tumors shrank, according to a news release from Experimental Biology 2009, a program of the American Society for Investigative Pathology.

Hopkins pathologist Dr. Akhilesh Pandey, who made the discovery, was expected to present the findings Saturday in New Orleans at the conference.

Although epidermal growth factor inhibitors had previously been tested as a pancreatic cancer treatment, Pandey and his team re-examined the studies and found that only one of 12 cancer samples tested contained the active pEGFR receptor.

The finding could lead to a biomarker detection tool for pancreatic cancer as well as a new treatment for these types of pancreatic cancers, Pandey said in the news release. His team is now reviewing scientific literature to compile a list of the proteins and genes known to be overexpressed in pancreatic cancers that should be considered future treatment targets.

More information

The American Cancer Society has more about pancreatic cancer.

-- Kevin McKeever

SOURCE: Federation of American Societies for Experimental Biology, news release, April 18, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
Related Image:
Research Takes Aim at Pancreatic Cancer
(Date:10/13/2015)... ... 13, 2015 , ... e-con Systems Inc., a leading embedded design services company ... industry’s first RGB-IR pixel format camera with a USB 3.0 interface and e-CAM40_CUMI4682_MOD, ... of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 - a 4-megapixel ...
(Date:10/13/2015)... ... , ... A child without a healthy mouth is much more likely to ... aligner system, has joined with Global Dental Relief (GDR) to help bring ... plan purchased, SmileCareClub will donate one clinic visit to a child in Kenya. , ...
(Date:10/13/2015)... ... , ... Protein is essential to good health. You need it to make ... much protein does the average man need in order to stay healthy? , ... issue of Harvard Men's Health Watch . Most Americans get about 15% of ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... a first-of-its kind product that targets the unique health needs of new ... the American Pregnancy Association ( ), utilizes Nordic Naturals’ exclusive, new, ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... in McHenry County, Illinois with more than 59,000 emergency department visits per year, ... system (EDIS) from T-System, to help improve clinical, operational and financial outcomes. ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015 Health Gorilla ( ... Clinical Network – a secure platform for clinical data ... patients interact about and manage healthcare in the US. The ... round, for a combined total of $4.4M raised to date, ... from True Ventures , Harris Barton , ...
(Date:10/13/2015)... CARLOS, Calif. , Oct. 13, 2015   ... development advisory firm in Quantitative Systems Pharmacology (QSP)/ PhysioPD™ ... Chief Engineer, will lead a workshop at the ... 2015 in Boston, MA.  The ... in pharmaceutical drug development.  Dr. Friedrich,s workshop is entitled ...
(Date:10/13/2015)... , Oct. 13, 2015 China Jo-Jo ... " China Jo-Jo "), a leading China-based retail, wholesale ... through its own online and retail pharmacies, announced preliminary ... official branded online pharmacy through , growing ... a record 25%. China Jo-Jo,s ...
Breaking Medicine Technology: