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Research Shows Why Statins Don't Work for Everyone
Date:6/16/2008

normal, he said. This is the first report of an alternatively spliced version.

"Statins are used by millions of people, so anything that affects the response to them is important," noted Dr. Michael Y. Tsai, director of the Lipid and Cardiovascular Risk Assessment Laboratory at the University of Minnesota.

"But this only accounts for 6 to 15 percent of the variation in response, so it is not enough to be clinically useful," Tsai added.

Nevertheless, he said, "this is making progress in the right direction."

Krauss agreed that there's more to the statin response than HMGCR. So, testing patients for the alternative splicing version of the protein before writing a statin prescription probably isn't in the cards for the near future, he said.

"This identifies a piece of the puzzle," Krauss noted. "There is considerable variation among individuals in how they respond to statins. If we can put all the pieces of the puzzle together, that would have clinical value. This is a big piece but not enough for clinical application."

More information

To learn about statins and who should be taking them, consult the American Heart Association.



SOURCES: Ronald Krauss, M.D., director, atherosclerosis research, Children's Hospital & Research Center, Oakland, Calif; Michael Y. Tsai, M.D., Ph.D., director, Lipid and Cardiovascular Risk Assessment Laboratory, University of Minnesota, Minneapolis; June 17, 2008, Circulation


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