Navigation Links
Research Shows Why Statins Don't Work for Everyone
Date:6/16/2008

A key protein change can lessen the cholesterol-lowering drugs' effectiveness

MONDAY, June 16 (HealthDay News) -- A genetic quirk in the production of one protein helps explain why some people don't get the full cholesterol-lowering benefit of statin drugs, researchers report.

Statins include blockbuster medications such as Crestor, Lipitor, Pravachol and Zocor.

The protein, abbreviated as HMGCR, plays a critical role in production of LDL cholesterol, the "bad" kind that clogs arteries, explained lead researcher Dr. Ronald Krauss, director of atherosclerosis research at the Children's Hospital Oakland Research Center in Oakland, Calif.

Some people use the HMGCR enzyme to produce LDL in an alternative way, however, and this difference is "strongly related to the LDL-lowering effect of statins," Krauss said.

At the heart of the process are protein fragments called exons that are spliced together to produce an active protein, he explained. Statins block LDL cholesterol production by binding to a particular exon when the protein is assembled. But depending on how this HMGCR splicing occurs, a statin drug has a better or worse chance of working as it should to lower cholesterol.

Krauss' team reported its findings in the June 17 issue of Circulation.

Krauss and his colleagues studied the genetic activity of HMGCR production in laboratory cell lines obtained from about 200 participants in a cholesterol study.

They found the alternatively spliced and less active version of the HMGCR protein in many of the cell lines. "Everyone has it to a greater or lesser degree," Krauss said. The incidence of the alternatively spliced protein was the same in whites and blacks, he said.

There have been previous reports of genetic variations in the protein, one of them from the group led by Krauss. Those involved point mutations, in which a specific unit of the protein chain was ab
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Shows Why Statins Don't Work for Everyone
(Date:1/22/2015)... (PRWEB) January 23, 2015 The U.S. ... R.Ph., DICVP, Director of Clinical Pharmacy Services at North ... the recipient of the 2015 Beal Award for Distinguished ... USP has relied on the contributions of volunteer experts ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 LunaDress, with its ... the fashion industry. Now, the business is showing its latest ... women’s dresses. , According to the company’s CEO, all the ... now offered with big discounts, up to 80% off. All ...
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ has ... (PPHA). The PPHA's passion for others' well-being and shared ... treated for obstructive sleep apnea (OSA) has propelled them into ... the valley. The most recent plans for an event will ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 The Incredible ... Bodybuilder Ben Pakulski to increase lean muscle by up to ... has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an ... that it is a step-by-step, scientific diet formula that allows ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2
... Calif., April 1, 2008 Gregory A. Adams ... for Kaiser,Foundation Health Plan, Inc., and Kaiser Foundation ... vice president of Kaiser,Permanente Hospital and Health Plan ... out as president of Northern California but,will continue ...
... Renovation is Open, PHOENIX, April 1, 2008 ... replaced Garcias, refried beans and rice,with 16,000 square feet ... lounge overlooking the refinished championship tennis court,and pristine Camelback ... 86,000., The new expansion houses a new entrance ...
... New Breads offer Latest Nutritional Advancements, FORT ... continuing effort,to pioneer the advancement of nutrition in ... 9 Grain with Omega-3 DHA. Active Health is ... United States while 9,Grain with Omega-3 DHA provides ...
... ROCHESTER, Minn. -- Obesity is more than a cosmetic ... high blood pressure, diabetes and many other serious health ... you expend through exercise and daily activities causes weight ... adults now considered obese, researchers are attempting to identify ...
... 2008 The Centers,for Medicare & Medicaid Services ... released HCAHPS scores that cover patient satisfaction,from an ... a patient,s,hospital experience. Virginia Hospital Center scored above ... the overall rating of the hospital,the likelihood that ...
... Corp. (OTC Bulletin,Board: CRDT), a leading healthcare staffing company, ... 2007., Revenue in the quarter was $9,806,540, an ... and an increase of 15% over revenue of,$8,531,970 in ... in the fourth quarter of 2007, compared to $1,570,923 ...
Cached Medicine News:Health News:Gregory A. Adams Named Northern California Region President of Kaiser Foundation Health Plan and Hospitals 2Health News:Gregory A. Adams Named Northern California Region President of Kaiser Foundation Health Plan and Hospitals 3Health News:Camelback Village Racquet & Health Club Devours the Entire Enchilada 2Health News:Oroweat Takes Health and Nutrition to the Next Level 2Health News:Mayo Clinic Proceedings examines link between bacteria in the digestive system and obesity 2Health News:Mayo Clinic Proceedings examines link between bacteria in the digestive system and obesity 3Health News:Virginia Hospital Center Reports HCAHPS Scores 2Health News:Crdentia Announces 2007 Fourth Quarter Results 2Health News:Crdentia Announces 2007 Fourth Quarter Results 3Health News:Crdentia Announces 2007 Fourth Quarter Results 4Health News:Crdentia Announces 2007 Fourth Quarter Results 5Health News:Crdentia Announces 2007 Fourth Quarter Results 6
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, Inc. today ... Inc. for the compounding, packaging and distributing of its naltrexone ... the United States . KRS ... compounding naltrexone tablets in various strengths for individual patients in ...
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
(Date:1/23/2015)... Africa , Jan. 23, 2015   Leatt Corporation ... personal protective equipment for all forms of sports, including ... Leatt-Brace® neck brace, announced today that the UISP Lega ... now requires all riders to wear a neck brace ...
Breaking Medicine Technology:Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
Barraquer needle holder, curved, delicate....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Yasargil Spring Hool with Bulldog Clamp, Galea hook....
Extremely fine straight....
Medicine Products: