Navigation Links
Research Shows Why Statins Don't Work for Everyone
Date:6/16/2008

A key protein change can lessen the cholesterol-lowering drugs' effectiveness

MONDAY, June 16 (HealthDay News) -- A genetic quirk in the production of one protein helps explain why some people don't get the full cholesterol-lowering benefit of statin drugs, researchers report.

Statins include blockbuster medications such as Crestor, Lipitor, Pravachol and Zocor.

The protein, abbreviated as HMGCR, plays a critical role in production of LDL cholesterol, the "bad" kind that clogs arteries, explained lead researcher Dr. Ronald Krauss, director of atherosclerosis research at the Children's Hospital Oakland Research Center in Oakland, Calif.

Some people use the HMGCR enzyme to produce LDL in an alternative way, however, and this difference is "strongly related to the LDL-lowering effect of statins," Krauss said.

At the heart of the process are protein fragments called exons that are spliced together to produce an active protein, he explained. Statins block LDL cholesterol production by binding to a particular exon when the protein is assembled. But depending on how this HMGCR splicing occurs, a statin drug has a better or worse chance of working as it should to lower cholesterol.

Krauss' team reported its findings in the June 17 issue of Circulation.

Krauss and his colleagues studied the genetic activity of HMGCR production in laboratory cell lines obtained from about 200 participants in a cholesterol study.

They found the alternatively spliced and less active version of the HMGCR protein in many of the cell lines. "Everyone has it to a greater or lesser degree," Krauss said. The incidence of the alternatively spliced protein was the same in whites and blacks, he said.

There have been previous reports of genetic variations in the protein, one of them from the group led by Krauss. Those involved point mutations, in which a specific unit of the protein chain was abnormal, he said. This is the first report of an alternatively spliced version.

"Statins are used by millions of people, so anything that affects the response to them is important," noted Dr. Michael Y. Tsai, director of the Lipid and Cardiovascular Risk Assessment Laboratory at the University of Minnesota.

"But this only accounts for 6 to 15 percent of the variation in response, so it is not enough to be clinically useful," Tsai added.

Nevertheless, he said, "this is making progress in the right direction."

Krauss agreed that there's more to the statin response than HMGCR. So, testing patients for the alternative splicing version of the protein before writing a statin prescription probably isn't in the cards for the near future, he said.

"This identifies a piece of the puzzle," Krauss noted. "There is considerable variation among individuals in how they respond to statins. If we can put all the pieces of the puzzle together, that would have clinical value. This is a big piece but not enough for clinical application."

More information

To learn about statins and who should be taking them, consult the American Heart Association.



SOURCES: Ronald Krauss, M.D., director, atherosclerosis research, Children's Hospital & Research Center, Oakland, Calif; Michael Y. Tsai, M.D., Ph.D., director, Lipid and Cardiovascular Risk Assessment Laboratory, University of Minnesota, Minneapolis; June 17, 2008, Circulation


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Shows Why Statins Don't Work for Everyone
(Date:2/20/2017)... ... February 20, 2017 , ... Researchers at the University of Pittsburgh School ... a marker that may predict response to a particular class of drugs, not just ... as well. The new findings were published in Proceedings of the National Academy of ...
(Date:2/20/2017)... , ... February 20, 2017 , ... ... welcomes you to stop by for a visit this week at HIMSS 2017 ... and executives from around the globe. Sensogram will be featured in the conference’s ...
(Date:2/20/2017)... ... February 20, 2017 , ... Johns Hopkins All Children's ... building. A topping out ceremony on Friday marked the halfway point of construction and ... open in Fall 2018, will serve as a center for innovation aimed at finding ...
(Date:2/19/2017)... Carolina (PRWEB) , ... February 19, 2017 , ... The ... evening undergraduate nursing students, is being led by Amelia Joseph, Ph.D. Joseph was engaged ... initial operations of the nursing department in early 2016. After a nation-wide search, she ...
(Date:2/19/2017)... ... February 19, 2017 , ... ... healthcare, will join forces with Healthwise ® at HIMSS 2017 ... industry leader in evidence-based health education, technology and services, will demonstrate a voice-powered ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... ORLANDO, Fla. , Feb. 20, 2017 /PRNewswire/ ... are helping physicians diagnose and treat patients with ... will provide wireless connectivity for ZywiePro, Zywie,s cardiac ... AT&T Control Center . AT&T ... accessible monitoring for those with the disease. The ...
(Date:2/20/2017)... 2017 Seal Shield LLC ( Jacksonville, ... mobile device management and disinfection, the ElectroClave™, to the ... in Orlando, Fla. from February ... have become commonplace in today,s healthcare landscape, but with ... concerns, including the disinfection and tracking of these devices.  ...
(Date:2/20/2017)... , Feb. 20, 2017 Research and Markets ... and Freezer Market Analysis and Trends - Product (RFID refrigerators and ... to 2025" report to their offering. ... The Global RFID Blood Refrigerator and ... 21.3% from 2015 to 2025. This industry report ...
Breaking Medicine Technology: