Navigation Links
Research Sheds Light on Why Autism Is More Prevalent in Boys
Date:9/15/2010

WEDNESDAY, Sept. 15 (HealthDay News) -- A new study is helping unravel an enduring mystery surrounding autism: Why boys are much more likely to be affected by the disorder than girls.

An international team led by Dr. John Vincent, of the Centre for Addiction and Mental Health in Toronto, examined specific genes in almost 3,000 people with an autism spectrum disorder (ASD) and 246 others with intellectual disability. They then compared that data to genes from more than 10,000 control individuals.

Reporting in the Sept. 15 issue of Science Translational Medicine, the team found that mutations in the PTCHD1 ("patched") gene are linked to inherited forms of autism and intellectual disability in about 1 percent of affected people in the study. It was not found in any of the controls, however.

"Our data indicate that mutations at the PTCHD1 locus are ... strongly associated with ASD," the researchers concluded.

They also noted that this gene is typically located on the single X-chromosome in males.

The study "provides further clues as to why ASD affects four times more males than females," said Andy Shih, vice president for scientific affairs at Autism Speaks. "PTCHD1 is part of a neurobiological pathway that determines the development of human embryos. It is one of several genes recently implicated in both ASD and intellectual disabilities."

The finding adds a little more clarity to the murky origins of autism, Shih said.

While each new genetic discovery "may only account for a small fraction of the cases, collectively they are starting to account for a greater percentage of individuals in the autism community, as well as providing insights into possible common pathogenic mechanisms," he said. "Identification of a male-linked genetic mutation begins to address the previously unknown basis for often reported skewed male-to-female ratio in autism."

More information

Find out more about autism at the U.S. National Institute of Neurological Disorders and Stroke.

-- E.J. Mundell

SOURCES: Sept. 15, 2010, Science Translational Medicine; Andy Shih, vice president, scientific affairs, Autism Speaks


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. OHSU research team joins elite consortium dedicated to curing type 1 diabetes
2. New research technology to target human gut bacteria
3. OHSU researchers able to determine brain maturity through analyzing MRI scans
4. University of Houston researcher receives National Award of Excellence in Research
5. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
6. European partnership funds research toward robot aides for the elderly
7. Researchers Develop Touch-Sensitive e-Skin
8. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
9. NYU researchers identify new neurological deficit behind lazy eye
10. Research shows unemployment programs lacking for people with disabilities
11. Pediatric vaccine stockpile policies need to be revisited, researcher says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Sheds Light on Why Autism Is More Prevalent in Boys
(Date:1/23/2017)... ... 23, 2017 , ... DMG Productions is proud to announce ... scheduled to broadcast Saturday, January 28, 2017 at 5:00pmEST. , This segment will ... address the limitations of fatigue monitoring technologies within the mining industry. Today SmartCap ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... organization in North America for the scientific development, healthcare training and clinical application ... Session, and its 2017 AAT Member Certification Qualification Courses for Technicians, respectively. , ...
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow video editors ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... text with video footage. ProRandom works by using a virtual camera to create the ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Crossing the Bar”: a moving and eloquent ... life. “Crossing the Bar” is the creation of published author, Charlotte Hotte, a North ... who credits the inspiration of the book to her sister, Denise, wishes to acknowledge ...
(Date:1/22/2017)... ... , ... Phytocéane invites clients to take an exotic journey deep into the ... MILKY CREAM. Inspired by the beauty of Zanzibar, a Tanzanian archipelago off the coast ... coral to create this gentle, velvety body cream to envelop the skin in moisture ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... InDex Pharmaceuticals Holding AB (publ) today announced ... of the European Crohn,s and Colitis Organisation (ECCO). The ECCO congress ... on inflammatory bowel disease (IBD). The congress is held in ... ... again having been selected to present data at the largest IBD ...
(Date:1/21/2017)... , Jan. 20, 2017 ResMed (NYSE: ... Medical ( Winter Haven, Florida ) today announced they ... parties. BMC and 3B will be permitted to sell their existing ... make a one-time settlement payment to 3B to close the ... did not include an admission of liability or wrongdoing by any ...
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... Trends - Technology, Route Of Administration, End User - Forecast to ... ... to grow at a CAGR of around 7.8% over the next ... This industry report analyzes the global markets for Advanced Drug Delivery ...
Breaking Medicine Technology: