Navigation Links
Research Sheds Light on Gene Linked to Preeclampsia
Date:2/17/2011

THURSDAY, Feb. 17 (HealthDay News) -- Pregnant women who develop a serious condition known as preeclampsia have an overabundance of a gene that helps regulate the body's immune system, researchers have found.

The findings may lead to improved screening and prenatal care for these patients and their babies, said the North Carolina State University researchers.

Preeclampsia is a sudden rise in blood pressure that can result in stroke, seizures or organ failure in the mother. The condition occurs in up to 10 percent of pregnancies and is responsible for about 15 percent of preterm births.

Recent research has focused on preeclampsia as an autoimmune disorder, in which the mother's body regards the placenta as an invader.

In this new study, the researchers compared genetic analyses of placentas from women with preeclampsia and from women with normal pregnancies.

"When we looked at the preeclampsic placentas, we found that several genes associated with a particular autoimmune pathway are 'upregulated' -- basically, that there were more of them in placentas of preeclampsic women than in normal placentas," study author and genomics professor Dr. Jorge Piedrahita said in university news release.

"More specifically, we found the upregulation of a particular enzyme involved in sialic acid modification called SIAE. Sialic acid coats every cell in our body, making it possible for our immune system to distinguish 'self' from 'not-self.' If this process is disrupted, the body can end up attacking itself."

Previous research has linked SIAE to autoimmune diseases such as rheumatoid arthritis and type 1 diabetes.

"Prior to this research, we knew that there was an autoimmune cascade effect with preeclampsia, but we didn't know where it originated. Now we know that disregulation of SIAE helps start the cascade. We've been able to fill in the blanks, and hopefully pregnant women and their babies will benefit as a result," Piedrahita said.

The study is published in the February issue of the journal Placenta.

More information

The U.S. National Institute of Child Health and Human Development has more about preeclampsia and eclampsia.

-- Robert Preidt

SOURCE: North Carolina State University, news release, Feb. 14, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Sheds Light on Gene Linked to Preeclampsia
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
Breaking Medicine Technology: