Navigation Links
Research Sheds Light on Cause of Brain Deficits in HIV Patients

TUESDAY, June 28 (HealthDay News) -- Some HIV patients experience memory loss and other neurological deficits, despite treatment, and new research suggests that the reason why is because the virus weakens the blood-brain barrier by infecting a small group of supporting brain cells called astrocytes.

The blood-brain barrier is a network of blood vessels that protects the brain from harmful chemicals and toxins. In healthy people, astrocytes help bolster the blood vessels that comprise the blood-brain barrier.

The finding, published in the June 29 issue of the Journal of Neuroscience, may help explain why 40 percent to 60 percent of HIV patients on antiretroviral therapy experience mild to moderate neurological problems such as learning difficulties.

For this study, the researchers built a model of the blood-brain barrier using human cells in the laboratory. The research was supported by the U.S. National Institute of Mental Health.

"Our results suggest HIV infection of astrocytes may be important in the onset of cognitive impairment in people living with the disease," study author Eliseo Eugenin, of Albert Einstein College of Medicine, said in a news release from the Society for Neuroscience.

"New therapies are needed that not only target the virus, but also to stop the virus from spreading damage to other uninfected brain cells," Eugenin added.

"Researchers have been stymied to explain why HIV-associated neurological complications persist, despite potent combination antiviral therapies that have dramatically improved health and survival," Igor Grant, an expert in HIV-associated neurocognitive impairment at the University of California, San Diego, said in the news release.

"This study provides a possible explanation indicating that minute numbers of infected astrocytes can trigger a cascade of signals that could open the brain to various toxic influences," explained Grant, who was not involved with the study.

More information

The American Psychiatric Association has more about mental health and HIV/AIDS.

-- Robert Preidt

SOURCE: Society for Neuroscience, news release, June 28, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers at Oregon Health & Science University discover MS-like disease in monkeys
2. Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
3. Religion benefits traumatic brain injury victims, Wayne State University research finds
4. Leading research organizations announce top-tier journal for biomedical and life sciences
5. New Crops for the Future Research Centre -- for food and non-food uses
6. Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report
7. UH Cancer Center receives $3.58 million gift for mesothelioma research
8. New application for iPhone may support monitoring and research on Parkinsons disease
9. TGen, Tecan and ASU Biodesign Institute develop sample preparation solution for proteomic research
10. Researchers identify components of speech recognition pathway in humans
11. Slowing the spread of drug-resistant diseases is goal of new research area
Post Your Comments:
Related Image:
Research Sheds Light on Cause of Brain Deficits in HIV Patients
(Date:10/13/2015)... ... October 13, 2015 , ... ... IBM software products, introduced a new company, RightSensor™ LLC, an Internet of Things ... capability. RightSensor™ provides a fully-managed approach for customers requiring sensor hardware for ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading embedded ... See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a USB 3.0 interface ... e-con’s See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 ...
(Date:10/13/2015)... ... ... Protein is essential to good health. You need it to make the bricks ... does the average man need in order to stay healthy? , The answer ... Harvard Men's Health Watch . Most Americans get about 15% of their calories ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... in McHenry County, Illinois with more than 59,000 emergency department visits per year, ... system (EDIS) from T-System, to help improve clinical, operational and financial outcomes. ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... World ... Driveway Snow Blanket, a snow melting invention that helps people in clearing snow away ... and will continue to grow at 3.8% per year," says Scott Cooper, CEO and ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015  EndoChoice Holdings, Inc. ... third quarter 2015 financial results on Thursday, November 5, ... . --> . ... Thursday, November 5, 2015 at 9:00 a.m. ET to ... for domestic callers and (412) 317-5469 for international callers. ...
(Date:10/13/2015)... , Oct. 13, 2015   Rosa & ... firm in Quantitative Systems Pharmacology (QSP)/ PhysioPD™ , today ... will lead a workshop at the QSP Congress ... Boston, MA.  The conference focuses ... drug development.  Dr. Friedrich,s workshop is entitled "Using Mechanistic ...
(Date:10/13/2015)... 13, 2015  Yesterday Congresswoman Renee Ellmers ... manufacturing site located in Holly Springs, NC ... produced Flucelvax ® (Influenza Vaccine) using cell-culture technology, a ... start-up and is not reliant on chicken eggs. 1,2 ... influenza vaccines business of Novartis AG in the US, ...
Breaking Medicine Technology: