Navigation Links
Research Reveals Why Tamoxifen Doesn't Always Work
Date:10/30/2008

Receptors on the surface of breast cancer cells may be the key, scientists say

THURSDAY, Oct. 30 (HealthDay News) -- Scientists have uncovered new clues to how breast cancer cells become resistant to the widely-used prevention and treatment drug tamoxifen.

The findings, from a team at Georgetown University Medical Center (GUMC), in Washington, D.C., could provide a way to identify tamoxifen users who have become resistant, so that doctors can try a better treatment option sooner.

According to the study, tamoxifen-resistant breast cancer cells display few of the "alpha" estrogen receptors that the drug is designed to bind with and inhibit. Instead, they display many more "gamma" estrogen-related receptors, which tamoxifen appears to activate, the researchers said.

The Georgetown group also tracked how, as tamoxifen resistance increases, breast cancer cells gradually lose their alpha receptors while gaining more estrogen-related gamma receptors.

The study, published in the Nov. 1 issue of the journal Cancer Research, offers two important new insights, according to lead author Rebecca Riggins, research assistant professor of oncology at GUMC's Lombardi Comprehensive Cancer Center.

First, it gives a clearer understanding of the importance of the gamma estrogen-related receptor in breast cancer.

"Until now, this receptor has not been viewed to be of much importance in any type of breast cancer. All that was known is that there were more of these receptors in breast cancer than in normal breast tissue, we hadn't got much further than that," Riggins said in a GUMC news release.

The findings could also help explain why invasive lobular carcinoma -- the subtype of breast cancer examined in this study -- may not respond as well to tamoxifen as other breast cancer subtypes.

"It is unclear whether tamoxifen is very effective in this cancer, and has been a point of debate among clinicians. This study is a good first step toward clarifying the role that tamoxifen resistance apparently plays in treatment of invasive lobular cancer," Riggins said.

More information

Breastcancer.org has more about tamoxifen.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, Oct. 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research Reveals Why Tamoxifen Doesn't Always Work
(Date:2/10/2016)... California (PRWEB) , ... February 09, 2016 , ... ... students, faculty and staff helped give free oral screenings to 150 children in ... 5, 2016. , The College of Dental Medicine joined Chinese American Dental Society ...
(Date:2/9/2016)... Fort Lauderdale, Florida (PRWEB) , ... February 09, 2016 , ... ... known as the Taste of South Florida Event, an upscale fundraiser held in South ... to wow sponsors and guests alike. This year the event will be held in ...
(Date:2/9/2016)... MA (PRWEB) , ... February 09, 2016 , ... ... (WCRI) compares the workers’ compensation fee schedule rates and Medicare rates for a ... services covered in the report, Evaluation of the 2015 Fee Schedule Rates ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul McElwee, a ... they noticed their furnace not producing any heat. Shortly after entering the home, Paul ... exchanger was leaking dangerous levels of carbon monoxide into the home, at 2,000 parts ...
(Date:2/9/2016)... ... February 09, 2016 , ... METTLER TOLEDO ... lab personnel have a basic understanding of the techniques they use so they ... will help them reduce waste and rework to create a leaner overall lab ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 10, 2016 The campaign aims ... 5 years reach the milestone of their 5 th ... ensure 2,50,532 children between the ages of 2 - 5 ... --> The campaign aims to ... reach the milestone of their 5 th birthday   ...
(Date:2/9/2016)... 9, 2016  Insulet Corporation (NASDAQ: PODD ) (Insulet ... technology with its OmniPod ® Insulin ... has been appointed to Insulet,s Board of Directors. With his ... of whom are independent. --> ... and finance experience and a deep knowledge of accounting, financial ...
(Date:2/9/2016)... QGEN ; Frankfurt Prime ... Genomics to develop and promote comprehensive solutions for ... --> QGEN ; Frankfurt Prime Standard: QIA) ... develop and promote comprehensive solutions for next-generation sequencing ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime ...
Breaking Medicine Technology: