Navigation Links
Research Reveals Nutrient's Impact on the Embryo
Date:11/19/2007

Vitamin A-derived retinoic acid helps guide development, scientists say

MONDAY, Nov. 19 (HealthDay News) -- U.S. researchers say they've uncovered new clues on how embryonic cells regulate levels of retinoic acid, a derivative of vitamin A.

Retinoic acid plays a vital role in embryo development, acting as a signal between cells to control development of the brain, limbs and many other tissues. Human embryos that get too much or too little retinoic acid may develop birth defects, noted a team from the University of California, Irvine.

When humans consume vitamin A -- found in many foods, including carrots, broccoli and sweet potatoes -- the body converts it into retinoic acid.

"If you don't get enough vitamin A in your diet -- or if you get too much -- your body compensates for that. Our study helps explain how this regulation occurs," Thomas Schilling, associate professor of developmental and cell biology at UC Irvine, said in a prepared statement.

The UC Irvine team examined retinoic acid in zebrafish embryos, which are often used in genetic studies as models for human development. They found that if levels of retinoic acid become too high, an enzyme called cyp26a1 degrades the excess retinoic acid in order to restore normal levels. If levels are too low, proteins called fibroblast growth factors (FGFs) slow retinoic acid degradation.

"Those two things work together to keep the whole system adjusted to the right level. Retinoic acid induces its own degradation, and FGFs, also present in the embryo, have the opposite effect by inhibiting retinoic acid degradation," Schilling said.

The study is published in the Nov. 20 issue of the journal Public Library of Science Biology.

More information

MedlinePlus has more about vitamin A.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, Nov. 19, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren ... base to accept new patients in need of skilled pediatric dentistry in ... Dental Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in ...
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic Imaging, ... therapeutic experience and operational excellence in oncology clinical trials, proudly announces today that ... treatment of non-small cell lung cancer and small cell lung cancer. , Throughout ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... consultation, financial planning, and related services to communities across eastern Texas, is announcing ... goal of providing meals to hungry children and adults. , Consistently a ...
(Date:3/22/2017)... ... March 22, 2017 , ... Chris Humphrey Insurance Agency, a North Carolina firm ... the coastal plains region, is initiating a charity event to raise support for five ... diagnosed with leukemia on a Friday evening in September 2014. At the time, Dillyn ...
(Date:3/22/2017)... ... March 22, 2017 , ... HumanHaus is proud to announce ... The conventional broom was great when it was invented, but our customers today are ... parents, the social young couple, the empty nesters and retired that want to travel. ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... LEXINGTON, Kentucky , March 22, 2017 ... Development and Manufacturing Organization (CDMO), held a special event ... its facilities in Lexington, Kentucky . ... Bevin , Piramal Group Chairman Ajay Piramal, and ... ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary  ... According to a report by ... estimated $6.6 billion in 2016, and is projected to grow at ... than $24 billion by 2025. The medical cannabis market is projected ... billion in 2016, to an estimated $13.3 billion in 2025. These ...
(Date:3/22/2017)... -- EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, ... Canada , today announced two new real-world data ... the 65 th Annual Pacific Coast Reproductive Society (PCRS) ... March 24 th .   The results being presented ... July 2009 to December 2015 containing data from 15 fertility ...
Breaking Medicine Technology: