Navigation Links
Research Reveals Nutrient's Impact on the Embryo
Date:11/19/2007

Vitamin A-derived retinoic acid helps guide development, scientists say

MONDAY, Nov. 19 (HealthDay News) -- U.S. researchers say they've uncovered new clues on how embryonic cells regulate levels of retinoic acid, a derivative of vitamin A.

Retinoic acid plays a vital role in embryo development, acting as a signal between cells to control development of the brain, limbs and many other tissues. Human embryos that get too much or too little retinoic acid may develop birth defects, noted a team from the University of California, Irvine.

When humans consume vitamin A -- found in many foods, including carrots, broccoli and sweet potatoes -- the body converts it into retinoic acid.

"If you don't get enough vitamin A in your diet -- or if you get too much -- your body compensates for that. Our study helps explain how this regulation occurs," Thomas Schilling, associate professor of developmental and cell biology at UC Irvine, said in a prepared statement.

The UC Irvine team examined retinoic acid in zebrafish embryos, which are often used in genetic studies as models for human development. They found that if levels of retinoic acid become too high, an enzyme called cyp26a1 degrades the excess retinoic acid in order to restore normal levels. If levels are too low, proteins called fibroblast growth factors (FGFs) slow retinoic acid degradation.

"Those two things work together to keep the whole system adjusted to the right level. Retinoic acid induces its own degradation, and FGFs, also present in the embryo, have the opposite effect by inhibiting retinoic acid degradation," Schilling said.

The study is published in the Nov. 20 issue of the journal Public Library of Science Biology.

More information

MedlinePlus has more about vitamin A.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, Nov. 19, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate ... Solutions Series of webinars will start January 31 with a session about understanding ... current health and benefits topics, including employee engagement, pricing transparency, population health and ...
(Date:1/24/2017)... ... 24, 2017 , ... This Saturday, January 28, the BCFA presents more than ... by Alabama Symphony Orchestra musicians Yifan Zhou, Mara McClain & Sarah Nordlund Dennis. Local ... exhibitors offer a look at Chinese games, crafts & more. Festivities begin at 11:00 ...
(Date:1/24/2017)... ... January 24, 2017 , ... The NewKILO JRP, a three-year project ... co-funded by the European Union (EU), was completed in May 2015. The future definition ... maintained and used in air, which presents some challenges to establishing traceability to the ...
(Date:1/24/2017)... ... January 24, 2017 , ... TopConsumerReviews.com recently gave a ... premenstrual syndrome, or PMS . , Most women of child-bearing age will experience ... constipation, irritability, headaches, fatigue, and other discomfort. For some women, the effects ...
(Date:1/24/2017)... ... ... “Mysteries Revealed On Speaking In Tongues”: an engaging and dynamic study on what ... On Speaking In Tongues” is the creation of published author, Tina Jackson, the editor, ... , “We need to partner with Jesus and be the voice piece to ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- Trifecta Clinical , a leading global provider ... Ward to Vice President of Commercial Operations.  Rick ... the promotion of Ericka Atkinson to Vice ... joins Trifecta from Greenphire where he was Vice President ... positions within the healthcare industry throughout his career.  "Rick ...
(Date:1/24/2017)... Results show Gamma Knife spares normal brain tissue ... Elekta (EKTA-B.ST) today announced new data demonstrating ... a higher radiation dose compared to linear accelerator (linac)-based delivery ... complex brain tumors, were published in the Journal ... ...
(Date:1/24/2017)... , January 24, 2017 www.Financialbuzz.com ... growing industries in the United States ... in 2016. In addition, Proposition 64, the California Cannabis Legalization ... 42.87% against on November 8, 2016. This outcome means that ... use and to grow a certain amount of cannabis for ...
Breaking Medicine Technology: