Navigation Links
Research Reveals Nutrient's Impact on the Embryo
Date:11/19/2007

Vitamin A-derived retinoic acid helps guide development, scientists say

MONDAY, Nov. 19 (HealthDay News) -- U.S. researchers say they've uncovered new clues on how embryonic cells regulate levels of retinoic acid, a derivative of vitamin A.

Retinoic acid plays a vital role in embryo development, acting as a signal between cells to control development of the brain, limbs and many other tissues. Human embryos that get too much or too little retinoic acid may develop birth defects, noted a team from the University of California, Irvine.

When humans consume vitamin A -- found in many foods, including carrots, broccoli and sweet potatoes -- the body converts it into retinoic acid.

"If you don't get enough vitamin A in your diet -- or if you get too much -- your body compensates for that. Our study helps explain how this regulation occurs," Thomas Schilling, associate professor of developmental and cell biology at UC Irvine, said in a prepared statement.

The UC Irvine team examined retinoic acid in zebrafish embryos, which are often used in genetic studies as models for human development. They found that if levels of retinoic acid become too high, an enzyme called cyp26a1 degrades the excess retinoic acid in order to restore normal levels. If levels are too low, proteins called fibroblast growth factors (FGFs) slow retinoic acid degradation.

"Those two things work together to keep the whole system adjusted to the right level. Retinoic acid induces its own degradation, and FGFs, also present in the embryo, have the opposite effect by inhibiting retinoic acid degradation," Schilling said.

The study is published in the Nov. 20 issue of the journal Public Library of Science Biology.

More information

MedlinePlus has more about vitamin A.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, Nov. 19, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... The Muscular Dystrophy Association and ... launched the 14th annual “Appetite for a Cure” campaign on Feb. 1 to ... and related diseases that severely limit strength and mobility. , Now through ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... President George H. Van Allen have signed a joint enrollment and degree completion ... seamless pathway toward associate and baccalaureate degrees at FHU|Dickson. , The agreement ...
(Date:2/5/2016)... , ... February 05, 2016 , ... US Sports ... Studio in Dover, NH to direct high-performance kids yoga training. ChildLight Yoga Studio is ... just one hour from Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her ...
(Date:2/5/2016)... New York (PRWEB) , ... February 05, 2016 , ... ... use and find themselves having to wait longer to access the treadmills. It’s a ... New Year’s resolutions to lose weight and get in shape by joining gyms, starting ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot ... 2015 Best in KLAS: Software & Services for HIT Implementation Support & Staffing ... report independently ranks vendor performance by healthcare executives, managers and clinicians representing over ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
(Date:2/4/2016)... ALBANY, N.Y. , Feb. 4, 2016  AMRI (NASDAQ: ... Vice President of Pfizer Inc. and President of Pfizer Global ... effective as of February 4, 2016. In addition, the Company ... member of the audit committee since 2010, has retired from ... time and attention to his other business ventures.  ...
(Date:2/4/2016)... SIOUX FALLS, S.D. , Feb. 4, 2016 ... patient and guest technology solutions, today announced that ... SONIFI Health Senior Living Engagement System. The system ... information tool that residents access through a tablet ... --> The resident engagement system provides access ...
Breaking Medicine Technology: