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Research Reveals How Mitochondrial Gene Defects Impair Respiration, Other Major Life Functions
Date:9/24/2009

dysfunction in animal models, and ways in which these consequences might themselves be treated. This work helps to suggest specific genes that may be the cause of mitochondrial disease in individual patients, as well as clarify the biology of how specific genes may cause disease. "Such work might one day benefit patients by pointing to specific drugs that alleviate secondary problems that arise when the respiratory chain cannot do its job," added Falk.

Grants from the National Institutes of Health supported this work. Falk's co-authors were Erzsebet Polyak, Ph.D., and Zhongxue Chen, Ph.D., of The Children's Hospital of Philadelphia; Julie R. Rosenjack and Wichit Suthammarak of Case Western Reserve University School of Medicine; and Phil G. Morgan, M.D., and Margaret M. Sedensky, M.D., of Case Western and also Seattle Children's Regional Medical Center.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

    Contact: John Ascenzi
    The Children's Hospital of Philadelphia
    267-426-6055
    Ascenzi@email.chop.edu


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SOURCE The Children's Hospital of Philadelphia
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