Navigation Links
Research Reveals How Mitochondrial Gene Defects Impair Respiration, Other Major Life Functions
Date:9/24/2009

PHILADELPHIA, Sept. 24 /PRNewswire-USNewswire/ -- Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function is essential to life, defects in mitochondria may affect a wide range of organ systems in humans and animals.

Some names of mitochondrial disorders are Leigh's disease, MELAS syndrome and complex I deficiency. These are often severe and progressive conditions that attack brain, muscles and numerous other parts of the body.

Mitochondrial diseases are individually very rare, but because hundreds of them exist, they collectively have a large impact, affecting at least 1 in 5,000 people, and perhaps more, who often remain undiagnosed. In addition to a wide array of diseases originating in the mitochondria itself, malfunctioning mitochondria also contribute to complex disorders like Parkinson's disease, Alzheimer's disease, epilepsy and diabetes, among others.

For such crucial biological actors, much remains unknown about exactly how mitochondria function. A new study, published Aug. 12 in the online journal PLoS One, sheds light on mitochondrial biology.

Using genetic engineering, researchers interrupted the activity of individual genes directly involved in the production of energy within mitochondria. "If we knock down the function of specific system components, what happens?" said study leader Marni J. Falk, M.D., who directs the Mitochondrial-Genetics Disease Clinic at The Children's Hospital of Philadelphia. "Our ultimate goal is to translate the knowledge into targeted therapies, that is, effective ways to intervene. But first we need to understand the underlying disease mechanisms."

Falk's team made use of a simple model organism often studied in biology, Ca
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... Boston University School of Medicine,s (BUSM) Pulmonary ... from the National Heart, Lung, and Blood Institute ... patients with lung disease. , Darrell Kotton, ... Gustavo Mostoslavsky, MD, PhD, assistant professor of medicine, ... award. Together Kotton and Mostoslavsky lead a multicenter ...
(Date:12/16/2009)... Global Market Expansion , ... Ramat-Gan, Israel (PRWEB) December ... to Web sites and companies, today announced a record year of ... Since its launch on July 2008, Kampyle has processed more than ... more than 30,000 customers in 191 countries., , ,Kampyle pioneered the ...
(Date:12/16/2009)... -- For ages, people from around the world have ... soothing waters have a reputation that dates back over ... miracles. Now, with the introduction of two bath salt ... the legendary benefits of Dead Sea salt in their ... all-natural Dead Sea salt and essential oils - but ...
(Date:12/16/2009)... WILMINGTON, Delaware, December 16 While ... outsource their accurate forecast models,for new and ... provides,integrated patient-based forecast solutions to various players. ... I, phase II, as well as phase,III. ... launch, product life cycle,management, market entry strategy, ...
(Date:12/16/2009)... has run marathons, competed in triathalons and appeared on ... -- Sarah Reinertsen likes to think of herself as part ... world is how the 34-year-old triathlete likes to describe herself. ... her speaking to packed school auditoriums or posing nude with ... the cover of the latest ESPN Body Issue. ...
Breaking Medicine News(10 mins):Health News:Boston University School of Medicine's pulmonary center receives $1.4 million grant 2Health News:Kampyle Experiences Record Growth in 2009 with 25,000 New Customers 2Health News:Kampyle Experiences Record Growth in 2009 with 25,000 New Customers 3Health News:Kampyle Experiences Record Growth in 2009 with 25,000 New Customers 4Health News:Kampyle Experiences Record Growth in 2009 with 25,000 New Customers 5Health News:SaltWorks Launches Two All-Natural Bath Salt Lines Featuring Therapeutic Salt from the Dead Sea 2Health News:SaltWorks Launches Two All-Natural Bath Salt Lines Featuring Therapeutic Salt from the Dead Sea 3Health News:MarketsandMarket's Integrated Patient-based Forecasting Solution for Pharmaceutical Industry, Mainly for Pipeline Products 2Health News:MarketsandMarket's Integrated Patient-based Forecasting Solution for Pharmaceutical Industry, Mainly for Pipeline Products 3Health News:Amputee Athlete Tells Her Story 2Health News:Amputee Athlete Tells Her Story 3Health News:Amputee Athlete Tells Her Story 4
... on health care,information technology will be speaking ... patient safety, HIT applications, privacy and,legislative activities ... be,held September 8-10, 2008, in Spokane, Washington. ... Physicians; John Glaser, PhD, Partners,Health Care; Micky ...
... Aug. 13 Wound Care,Innovations, LLC, a subsidiary ... is excited about expanding upon the announcement,that was ... independent case,reports utilizing their advanced wound care collagen ... Skin and Wound Care.,The case presentations were on ...
... Corporation,announced today that for the second quarter ended June ... million or 3 cents per share, on,revenues of $4.8 ... a consolidated net loss of $7.4 million, or 8 ... loss from continuing operations was $1.9 million for the ...
... working in more than 30,earthquake-affected communities in Peru, ... massive,earthquake struck this region last August 15th, it ... homeless.,Although the spotlight has moved on, the American ... the Peruvian Red Cross to help families rebuild,physically ...
... plan to significantly involve their workers in long-term strategies to control ... survey released today by Buck Consultants. , ... New ... their workers in long-term strategies to control prescription drug costs. This ...
... of The Blue Lion Foundation is raffling her tickets to see her ... of all ages to overcome challenges through persistence and determination. , ... ... tickets for her to The Jonas Brothers, she decided to give away ...
Other Medicine News:Health News:Wound Management Technologies, Inc. Announces Clarification of Eprint Viewing of Case Report in Advances in Skin and Wound Journal 2Health News:Westaim announces 2008 second quarter results 2Health News:Westaim announces 2008 second quarter results 3Health News:Westaim announces 2008 second quarter results 4Health News:One Year Later: Red Cross Helping Peru Earthquake Survivors Rebuild 2Health News:Employee Involvement Is Key to Long-Term Pharmacy Cost Control, Finds Buck Consultants Survey 2Health News:Employee Involvement Is Key to Long-Term Pharmacy Cost Control, Finds Buck Consultants Survey 3Health News:Employee Involvement Is Key to Long-Term Pharmacy Cost Control, Finds Buck Consultants Survey 4Health News:Pittsburgh Teen Raffles Her Jonas Brothers Tickets to Educate and Inspire 2Health News:Pittsburgh Teen Raffles Her Jonas Brothers Tickets to Educate and Inspire 3
(Date:12/16/2009)... MAQUET Cardiovascular LLC, a leading provider of ... signed a three-year single source provider contract ... company, for MAQUET,s market-leading VASOVIEW Endoscopic Vessel ... healthcare providers in obtaining veins for repair ... incisions. This allows for faster healing, less ...
(Date:12/16/2009)... Inc., a new clinical stage company developing innovative ... on its novel GFPA NMDA receptor modulators, today ... meeting showed that its lead compound GLYX-13 demonstrated ... of the CNS-related side effects seen with other ... also showed that GLYX-13,s antidepressant effects were evident ...
(Date:12/16/2009)... Keryx Biopharmaceuticals, Inc. (Nasdaq: ... a Phase 3 registration clinical trial for ... in relapsed / refractory multiple myeloma patients. ... Randomized Study to Assess the Efficacy and ... of Bortezomib (Velcade®) and Dexamethasone in Multiple ...
Breaking Medicine Technology:MAQUET Cardiovascular Awarded Three-Year Single Source Contract From Novation for VASOVIEW Endoscopic Vessel Harvesting Devices 2MAQUET Cardiovascular Awarded Three-Year Single Source Contract From Novation for VASOVIEW Endoscopic Vessel Harvesting Devices 3MAQUET Cardiovascular Awarded Three-Year Single Source Contract From Novation for VASOVIEW Endoscopic Vessel Harvesting Devices 4Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects 2Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects 3Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects 4Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects 5Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects 6Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 2Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 3Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 4Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 5Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 6Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma 7Video 3A truth 28R 29 Asks 3A Do You Have What it Takes 3F 47479 1Video 3A truth 28R 29 Asks 3A Do You Have What it Takes 3F 47479 2Video 3A truth 28R 29 Asks 3A Do You Have What it Takes 3F 47479 3Video 3A truth 28R 29 Asks 3A Do You Have What it Takes 3F 47479 4S C BlueCross Makes Coverage Available for Thousands of South Carolina Graduates Lacking Health Insurance 47474 1S C BlueCross Makes Coverage Available for Thousands of South Carolina Graduates Lacking Health Insurance 47474 2Wet ear wax and unpleasant body odors signal breast cancer risk 8673 1Wet ear wax and unpleasant body odors signal breast cancer risk 8673 2
... many challenges in treating patients with cancer, treating ... quite difficult as studies,suggest that certain therapies can ... study prepublished today online in Blood, the official,journal ... treated with,imatinib, a commonly used therapy for chronic ...
... Memory Formula(TM), PURCHASE, N.Y., March 4 ... and marketer of nutritional supplements that,help consumers manage ... address chronic joint pain, today announced the results,of ... 1000 mcg of,chromium, as chromium picolinate, increased brain ...
Other Medicine Technology:Leukemia Therapy With Imatinib During Pregnancy May Cause Infant Abnormalities 2Leukemia Therapy With Imatinib During Pregnancy May Cause Infant Abnormalities 3New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults 2New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults 3New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults 4
100L...
... is precision, ergonomics, and value!, ... with soft non-slip, contoured handle , ... light plunger spring action , Completely ... without the need for recalibration , ...
Inquire...
... Focus from Thermo Labsystems was ... with uncompromising performance. The ... a custom fit for different ... tip cones allow easier and ...
Medicine Products: