Navigation Links
Research Reveals How Mitochondrial Gene Defects Impair Respiration, Other Major Life Functions
Date:9/24/2009

PHILADELPHIA, Sept. 24 /PRNewswire-USNewswire/ -- Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function is essential to life, defects in mitochondria may affect a wide range of organ systems in humans and animals.

Some names of mitochondrial disorders are Leigh's disease, MELAS syndrome and complex I deficiency. These are often severe and progressive conditions that attack brain, muscles and numerous other parts of the body.

Mitochondrial diseases are individually very rare, but because hundreds of them exist, they collectively have a large impact, affecting at least 1 in 5,000 people, and perhaps more, who often remain undiagnosed. In addition to a wide array of diseases originating in the mitochondria itself, malfunctioning mitochondria also contribute to complex disorders like Parkinson's disease, Alzheimer's disease, epilepsy and diabetes, among others.

For such crucial biological actors, much remains unknown about exactly how mitochondria function. A new study, published Aug. 12 in the online journal PLoS One, sheds light on mitochondrial biology.

Using genetic engineering, researchers interrupted the activity of individual genes directly involved in the production of energy within mitochondria. "If we knock down the function of specific system components, what happens?" said study leader Marni J. Falk, M.D., who directs the Mitochondrial-Genetics Disease Clinic at The Children's Hospital of Philadelphia. "Our ultimate goal is to translate the knowledge into targeted therapies, that is, effective ways to intervene. But first we need to understand the underlying disease mechanisms."

Falk's team made use of a simple model organism often studied in biology, Ca
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Yesterday, Senator Holly Mitchell (D-Los ... Olsen (R-Modesto) were honored by the California Healthcare ... biomedical science, medical device and pharmaceutical innovation in ... “2014 Life Sciences Champion” award from CHI President ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and easy ... treat specific body parts and muscle groups. , IsoComforter, ... use patented cold therapy machine with the innovative IsoTube design ... injuries. IsoComforter has become the industry leader in cold ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Payday lending ... vulnerable communities and cause financial distress to the states ... analysts at Howard University’s Center on Race and Wealth. ... in economic activity, payday loans at the same time ...
(Date:1/22/2015)... January 22, 2015 As interest in the ... care gains momentum worldwide, Rev. Eric J. Hall , ... Network (HCCN), will be the keynote speaker on January ... Israel’s public health system. , The conference, “Hope and Resilience: ...
(Date:1/22/2015)... released a new blog post presenting a list of vehicles that ... , Some types of vehicles cannot be covered under an ordinary ... to see if their vehicle qualifies for auto insurance coverage. ... cars that cannot be covered by a plan. Clients have little ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... (Sept. 20, 2007) A Jekyll-Hyde mechanism that both ... the basis for new cancer-fighting drugs. , Scientists in ... that a certain transcription factora protein that binds to ... genes on and offknown to aid in handling stresses ...
... scientist at Leeds whose research is challenging conventional thinking ... has secured funding to further investigate her findings. , ... Sciences has been awarded 80,000 from Heart Research UK ... affecting the heart muscle cell. , For ...
... the agency is doing , , THURSDAY, Sept. 20 ... prescription medicines for health, many are confused and distrustful ... new survey finds. , In fact, many of those ... and Drug Administration approves drugs, and almost half judged ...
... Developments in Solid Organ Transplantation, DALLAS, ... Review",is the focus of a one-day meeting ... Grapevine, Texas. Co-sponsored by the American Society ... Professionals,(NATCO), the conference agenda contains information about ...
... Increase ... SAN ANTONIO, Sept. 20 AT&T Inc. (NYSE: ... portfolio of radio frequency,identification (RFID) tracking offers for health ... operations of hospitals and other,health care facilities. AT&T ...
... MDA stunning discovery by German scientists may make blood ... as washing your hair. In the October print issue ... that the estimated 100,000 hair follicles on each persons ... EPO, the hormone primarily responsible for the creation of ...
Cached Medicine News:Health News:Heat shock proteins are co-opted for cancer 2Health News:Research to shed new light on how statins benefit heart patients 2Health News:Americans Confused About FDA and Drug Safety 2Health News:Americans Confused About FDA and Drug Safety 3Health News:Americans Confused About FDA and Drug Safety 4Health News:Dallas-Area Transplant Meeting Puts Spotlight on Key Issues 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 3Health News: New discovery leaves blood-doping athletes scratching their heads 2
(Date:1/22/2015)... ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular disease and ... of the Company,s accomplishments in 2014 and its outlook for ... Dear Fellow Shareholders, We would like to ...
(Date:1/22/2015)... (NASDAQ: TECH ) announced today that it ... Simple Plex platform through its Proteins Platform division under ... the previously acquired CyPlex instrument platform from CyVek. ... technology which integrates an innovatively designed microfluidic cartridge with ...
(Date:1/22/2015)... 22, 2015 Increasing sophistication among enterprise buyers of ... purchasing in 2015, says Moravia CMO, ... study by market research firm Common Sense Advisory, 15 ... their translation and localization needs. "From a language industry ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... Comprehensive Care Corporation (OTC BB: CHCR), a leading ... provider for managed care companies throughout the U.S., today ... Rx Inc., has been selected as the new President ... the healthcare industry, is a graduate of the United ...
... -- Dehaier Medical Systems Ltd. (Nasdaq: ... leader in the development, assembly, marketing and sale of ... announced that it will release financial results for the ... on Monday, November 14, 2011 before the start of ...
Cached Medicine Technology:Comprehensive Care Corporation Names Robert R. Kulbick New President 2Comprehensive Care Corporation Names Robert R. Kulbick New President 3Dehaier Medical to Report Third Quarter 2011 Financial Results on November 14 2
... modular cleanroom for biological safety labs ... cleanliness (to Class 10/ISO 3) and ... create ultra-smooth surfaces that are easy ... radius corners simplify cleaning. Unique double-wall ...
Inquire...
Inquire...
Inquire...
Medicine Products: